YN320299 Orexin A (human, rat, mouse) 205640-90-0

Orexin A human, rat, mouse, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A human, rat, mouse is a specific, high-affinity agonist for G-protein-coupled receptorOX1R. Orexi...

YN321924 Orexin B, human 205640-91-1

Orexin B, human is an endogenous agonist atOrexinreceptor with Kis of 420 and 36nM for OX1 and OX2, respectively.

YN360675 RWJ-51204 205701-85-5

RWJ-51204 is a partial agonist ofGABA(A) receptor, with Kiof 0.2-2nM to the benzodiazepine site on GABA(A) receptors.

YN361039 L-R4W2 206350-79-0

L-R4W2 is a potent antagonist ofvanilloid receptor 1 (VR1, TRPV1), with an IC50 of 0.1μM. L-R4W2 may act as a potent analgesic.

YN380213 Tacrine hydrochloride hydrate 206658-92-6

Tacrine is a centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. It...

YN322108 L-Cysteinesulfinic acid mono... 207121-48-0

L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8,...

YN360195 3-Bromocytisine 207390-14-5

3-Bromocytisine (3-Br-cytisine) is a potentnAChreceptors agonist, with IC50s are 0.28, 0.30 and 31.6nM for hα4β4, hα4β2, and hα7-nACh, respectively. 3-Bromocytisine (3-Br-cytisine) shows different effects on high (HS) ...

YN380220 Rutin hydrate 207671-50-9

Rutin is a glycoside found in a wide variety of plants including citrus fruit.

YN321874 HS014 207678-81-7

HS014 is a potent and selectivemelanocortin-4 (MC4) receptorantagonist, with Kis of 3.16, 108, 54.4 and 694nM for human MC4, MC1, MC3 and MC5 receptors, respectively. HS014 modulates the behavioral effects of morphine ...

YN321307 Desfesoterodine 207679-81-0

5-hydroxymethyl tolterodine (PNU 200577) is a new muscarinic receptor antagonist with Kb of 0.84 nM.

YN320912 Befiradol 208110-64-9

Befiradol (NLX-112) is a selective5-HT1Areceptor agonist.

YN380070 DAPT 208255-80-5

DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells.

YN360486 Tebanicline dihydrochloride 209326-19-2

Tebanicline dihydrochloride (Ebanicline dihydrochloride) is anAChRmodulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM.

YN380024 Ladostigil 209394-27-4

Ladostigil (TV-3326) is a dual inhibitor ofcholinesterase and brain-selectivemonoamine oxidase (MAO), with an IC50 of 37.1 and 31.8μM forMAO-B and AChE, reapectively. Ladostigil could increase cholinergic transmission, ...

YN320852 SB 271046 Hydrochloride 209481-24-3

SB 271046 hydrochloride is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9, exhibits 200-fold greater selectivity over other 5-HT receptor subtypes.

YN483860 CART(55-102)(rat) 209615-79-2

CART(55-102)(rat) is a rat satiety factor with potent appetite-suppressing activity. CART(55-102)(rat) is closely associated with leptin and neuropeptide Y. CART(55-102)(rat) can induces anxiety and stress-related behavior.

YN320100 AR-M 1000390 hydrochloride 209808-47-9

AR-M 1000390 hydrochloride is an exceptionally selective, potentδ opioid receptoragonist with an EC50 of 7.2±0.9nM for δ agonist potency.

YN380140 LY-411575 209984-57-6

LY411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082 nM (membrane/cell-based), also inhibits Notch cleavage with IC50 of 0.39 nM in APP or NΔE expressing HEK293 cells.

YN380141 LY-411575 isomer 1 209984-58-7

LY-411575 isomer 1 is an isomer of LY411575, which is a potent γ-secretase inhibitor.

YN481577 Miglustat hydrochloride 210110-90-0

Miglustat hydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1).