YN320538 p-MPPI hydrochloride 220643-77-6

p-MPPI hydrochloride is a selective5-HT1A receptorantagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects.

YN322075 (4E)-SUN9221 222318-55-0

(4E)-SUN9221 is a potent antagonist ofα1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities.

YN320911 Adoprazine 222551-17-9

Adoprazine, a potential atypical antipsychotic bearing potent D2 receptor antagonist and 5-HT1A receptor agonist properties. Adoprazine is a full 5-HT1A receptor agonist and full D2/3 receptor antagonist possessing characteris...

YN322010 T 82 252264-92-9

T 82 is a potent5-HT3antagonist and acetylcholinesterase (AChE)inhibitor, used for treatment of Alzheimer's Disease.

YN320968 SB-269970 hydrochloride 261901-57-9

SB269970 HCl is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors.

YN320937 Pardoprunox hydrochloride 269718-83-4

Pardoprunox (SLV-308, DU-126891, SME-308) hydrochloride (HCl) is a potent but partial dopamine D2 receptor agonist with pEC50 of 8.0, and a partial agonist in the induction of [³⁵S]GTPγS binding ...

YN320936 Pardoprunox 269718-84-5

Pardoprunox (SLV-308) is a partialdopamine D2 and D3 receptorpartial agonist and aserotonin 5-HT1A receptoragonist, withpEC50s of 8, 9.2, and 6.3, respectively.

YN320230 NPS ALX Compound 4a 299433-10-6

NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine6(5-HT6) receptorantagonist, with an IC50 of 7.2nM and a Ki of 0.2nM.

YN320237 PU02 313984-77-9

PU02, a derivative of 6-MP (HY-13677), is a negative allosteric modulator (NAM) of5-HT3receptor, with IC50 values of 0.36 and 0.73μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respective...

YN320405 5-HT7 agonist 1 334974-31-1

5-HT7 agonist 1 is a selective5-HT7 receptoragonist, with an IC50 of 222.93nM, can be used for the 5-HT7 receptor related disease, such as CNS disorders.

YN321224 Roluperidone 359625-79-9

Roluperidone (CYR-101) is a novel cyclic amide derivative that has high equipotent affinities for5-HT2A and sigma-2receptors (Kiof 7.53nM and 8.19nM for 5-HT2A and sigma-2, respectively).

YN321377 Lurasidone 367514-87-2

Lurasidone is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki = 1 nM and Ki = 0.5 nM, respectively. It also has high affinity for serot...

YN321376 Lurasidone Hydrochloride 367514-88-3

Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is an antagonist of bothdopamine D2 and 5-HT7with IC50s of 1.68 and 0.495nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agon...

YN320231 SB-399885 hydrochloride 402713-81-9

SB-399885 hydrochloride is a5-HT6receptorantagonist.

YN320853 Idalopirdine Hydrochloride 467458-02-2

Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) is a potent and selective5-HT6 receptorantagonist with a Ki of 0.83nM.

YN320154 NEO 376 496921-73-4

NEO 376 is a selective modulator of 5-HT1 receptor,GABA receptor and dopamine receptor, with anti-psychotic actively.

YN320978 Vortioxetine 508233-74-7

Vortioxetine, a novel antidepressant for the treatment of major depressive disorder, is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and serotonin (5-HT) transporter...

YN320855 WAY-181187 554403-49-5

WAY-181187 (SAX-187) is a potent and selective full5-HT6receptor agonist with a Ki of 2.2nM and an EC50 of 6.6nM. WAY181187 mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinas...

YN320854 Intepirdine 607742-69-8

SB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. Phase 2.

YN321251 F-15599 635323-95-4

F-15599 is a highly selective G-protein biased5-HT1A receptoragonist, with Kiof 3.4nM.