YN321228 Ro 46-2005 150725-87-4

Ro 46-2005 is a novel synthetic non-peptide endothelin receptor antagonist, inhibits the specific binding of 125I-ET-1 to human vascular smooth muscle cells (ETA receptor) with IC50 of 220nM.

YN300047 Tirofiban hydrochloride monoh... 150915-40-5

Tirofiban Hydrochloride is the hydrochloride salt form of tirofiban, a selective platelet GPIIb/IIIa antagonist which inhibits platelet aggregation. It is more soluable than Tirofiban.

YN321427 Nebivolol hydrochloride 152520-56-4

Nebivolol HCl selectively inhibits β1-adrenoceptor with IC50 of 0.8 nM.

YN373977 Win-62005 152633-54-0

Win-62005 is a cyclic AMP phosphodiesterase III (PDE III) inhibitor with Kis of 25 and 26nM for rat heart and canine aorta, respectively.

YN321833 Hemorphin-7 152685-85-3

Hemorphin-7 is a hemorphin peptide, an endogenous opioid peptide derived from the β-chain of hemoglobin. Hemorphin peptides exhibits antinociceptive and antihypertensive activities, activating opioid receptors and inhibiting angioten...

YN361066 KRN4884 152802-84-1

KRN4884 is aK+channelopener. In the presence of intracellular ATP (1 mM), KRN4884 (0.1-3μM) activatesKATPchannels in a concentration-dependent manner (EC50=0.55μM).

YN321008 Piboserod 152811-62-6

Piboserod (SB 207266) is a selective 5-HT(4) receptor antagonist.

YN371614 6-Hydroxybenzbromarone 152831-00-0

6-Hydroxybenzbromarone is the majormetaboliteof Benzbromarone with a longer half-life and greater pharmacological potency than the parent compound. 6-Hydroxybenzbromarone is aprotein Eyes Absent 3 (EYA3)inhibitor with an IC50 ...

YN340135 AG-1478 153436-53-4

AG-1478 (Tyrphostin AG-1478) is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR.

YN360337 NS-1619 153587-01-0

NS-1619 is a selective activator of large conductance Ca2+-activated K+-channels.

YN320152 Pratosartan 153804-05-8

Pratosartan is a selectiveangiotensin II receptorantagonist.

YN370866 Atreleuton 154355-76-7

Atreleuton (ABT-761) is a selective, reversible, and orally bioavailable5-Lipoxygenase (5-LO)inhibitor. Atreleuton (ABT-761) exhibits potent and selective inhibition of leukotriene formation .

YN483883 Adrenomedullin (AM) (13-52)... 154765-05-6

Adrenomedullin (AM) (13-52), human is a 40 amino acid peptide, which acts as an endothelium-dependent vasodilator agent.

YN372220 (3R,5S)-Fluvastatin 155229-75-7

(3R,5S)-Fluvastatin is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductaseinhibitor with an IC50 of 8nM. Fluvastatin protects vascular smooth muscle ce...

YN372565 Inogatran 155415-08-0

Inogatran (H-314-27) is a syntheticthrombininhibitor, developed for the possible treatment and prophylaxis of arterial and venous thrombotic diseases.

YN450087 Hydroxyfasudil hydrochloride 155558-32-0

Hydroxyfasudil hydrochloride is aROCKinhibitor, with IC50s of 0.73 and 0.72μM forROCK1 and ROCK2, respectively.

YN483173 Vinaginsenoside R8 156042-22-7

Vinaginsenoside R8, a triterpenoid glycoside isolated from the rhizomes ofPanacis majoris. Vinaginsenoside R8 displays activities against adenosine diphosphate (ADP)-induced platelet aggregation (IC50=25.18μM).

YN321046 BQ-788 sodium salt 156161-89-6

BQ-788 sodium salt is a potent and selectiveETB receptorantagonist, inhibiting ET-1 binding to ETB receptors with an IC50 of 1.2nM in human Girrardi heart cells.

YN360328 Rostafuroxin 156722-18-8

Rostafuroxin (PST 2238), a digitoxigenin derivative, is an orally active  and  potentNa+,K+-ATPase (ATP1A1)antognist. Rostafuroxin binds specifically to the ATP1A1 extracellular domain  and  blocks r...

YN483745 GPRP acetate 157009-81-9

GPRP acetate (Gly-Pro-Arg-Pro acetate) is a fibrin polymerization inhibitor that inhibits the interaction of fibrinogen with the platelet membrane glycoprotein IIb/IIIa complex (GPIIb/IIIa).