YN321047 BQ-788 173326-37-9

BQ-788 is a potent, selectiveETB receptorantagonist with IC50 of 1.2nM for inhibition of ET-1 binding to human Girardi heart cells, poorly inhibiting the binding to ETA receptors in human neuroblastoma cell line SK-N-MC c...

YN370931 Aliskiren 173334-57-1

Aliskiren is a renin inhibitor with antihypertensive activity.

YN370933 Aliskiren hemifumarate 173334-58-2

Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM.

YN320974 Atrasentan 173937-91-2

Atrasentan (ABT-627) is anendothelin receptorantagonist with IC50 of 0.0551nM for ETA.

YN1570004 Nepicastat 173997-05-2

Nepicastat (SYN117) is a selective, potent, and orally active inhibitor ofdopamine-beta-hydroxylase. Nepicastat (SYN117) produces concentration-dependent inhibition of bovine (IC50=8.5nM) and human (IC50=9nM) dopamine-beta...

YN483716 Epimedin K 174286-13-6

Epimedin K (Korepimedoside B), a flavonol glycoside, is isolated from the aerial parts ofEpimedium koreanumNakai.Epimedium koreanumNakai is a famous Chinese herbal medicine for the research of impotence, osteoporosis, immune suppre...

YN320071 SR59230A 174689-39-5

SR59230A is a potent, selective, and blood-brain barrier penetratingβ3-adrenergic receptorantagonist with IC50s of 40, 408, and 648nM for β3, β1, and β2 receptors, respectively.

YN320706 Ambrisentan 177036-94-1

Ambrisentan is a highly selective antagonist of the endothelin-1 type A receptor, used in the treatment of pulmonary arterial hypertension (PAH).

YN484262 Implitapide Racemate 177277-99-5

Implitapide Racemate is the racemate of Implitapide. Implitapide is a microsomal triglyceride transfer protein (MTP) inhibitor.

YN480290 Implitapide 177469-96-4

Implitapide (AEGR 427) is a microsomal triglyceride transfer protein (MTP) inhibitor.

YN320157 PD-159020 177904-00-6

PD-159020 is a non-selectiveETA/ETBantagonist, with IC50s of 30 and 50nM for hETA and hETB, respectively.

YN321009 Piboserod hydrochloride 178273-87-5

Piboserod (SB 207266) Hcl is a selective 5-HT(4) receptor antagonist.

YN483244 Vitexin-4''-O-glucoside 178468-00-3

Vitexin-4''-O-glucoside is a kind of flavonoid fraction from the leaves ofCrataegus pinnatifida.

YN320970 Talibegron hydrochloride 178600-17-4

Talibegron hydrochloride (ZD2079 hydrochloride) is a potentβ3-adrenoceptoragonist with a pD2of 3.72 on phenylephrine-preconstricted rat mesenteric artery. Talibegron hydrochloride has potent vasorelaxant effect.

YN372573 PD 151746 179461-52-0

PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain.

YN361080 CP-060 180090-15-7

CP-​060 is a potentCa2+antagonist, inhibits Ca2+overload and possesses antioxidant and cardioprotective activities.

YN321118 Tezosentan 180384-57-0

Tezosentan (RO 610612) is anendothelin (ET)receptor antagonist, withpA2sof 9.5, 7.7 for ETA and ETBreceptors, respectively.

YN484181 LDL-IN-3 180908-67-2

LDL-IN-3 is an anti-atherosclerotic compound extracted from patent WO/2005/039596A1, example C25 and patent US 6133467, example 3.

YN290315 Ombrabulin 181816-48-8

Ombrabulin (AVE8062) is a derivative of CA-4 phosphate, which is known to exhibit antivascular effects through selective disruption of thetubulincytoskeleton of endothelial cells.

YN481400 Lomitapide 182431-12-5

Lomitapide is a potent microsomal triglyceride transfer protein (MTP) inhibitor, used in the treatment of familial hypercholesterolemia.