YN360621 Clevidipine 167221-71-8

Clevidipine Butyrate is a dihydropyridine calcium channel blocker, uses as an agent for the reduction of blood pressure.

YN372474 Omapatrilat 167305-00-2

Omapatrilat is a dual inhibitor of the metalloproteases ACE and NEPwith Ki values of 0.64 and 0.45nM, respectively.

YN320161 OPC-28326 167626-17-7

OPC-28326 is a selective peripheral vasodilator and an angatonist ofα2-adrenergic receptor, with Kiof 2040, 285, and 55 nM for α2A-, α2B- and α2C-adrenoceptors, respectively.

YN320833 Lixivaptan 168079-32-1

Lixivaptan (VPA-985, WAY-VPA 985) is an orally active and selectivevasopressin receptorV2 antagonist, with IC50 values of 1.2 and 2.3nM for human and rat V2, respectively.

YN321184 Conivaptan hydrochloride 168626-94-6

Conivaptan HCl is an orally active, non-peptide, vasopressin V1A and V2 receptor antagonist, used in the treatment of euvolemic and hypervolemic hyponatremia.

YN320162 L162389 169281-53-2

L162389 is a potent antagonist ofangiotensin AT1 receptor with Kiof 28nM.

YN373997 FCE 28654 169474-77-5

FCE 28654 is a water soluble inhibitor of acylCoA: cholesterol acyltransferase (ACAT), weakly inhibitingACATin microsomes from rabbit aorta and intestine, and monkey liver, with IC50s of 2.55, 1.08 and 5.69μM, respcet...

YN320263 IRL 2500 169545-27-1

IRL 2500 is a potentEndothelin receptorantagonist. IRL 2500 showsIC50 values of 1.3 and 94nM for ETB and ETAreceptors, respectively. IRL 2500 inhibits ETB receptor-mediated blood pressure increase and renal vascu...

YN1570005 Nepicastat hydrochloride 170151-24-3

Nepicastat (SYN-117) HCl is a potent and selective inhibitor of both bovine and human dopamine-β-hydroxylase with IC50 of 8.5 nM and 9 nM, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors....

YN340136 AG-1478 hydrochloride 170449-18-0

AG-1478 hydrochloride (Tyrphostin AG-1478 hydrochloride) is a selectiveEGFRtyrosine kinase inhibitor with IC50 of 3nM. AG-1478 hydrochloride has antiviral effects againstHCV and encephalomyocarditis virus (EMCV).

YN330703 SC-236 170569-86-5

SC-236 is an orally activeCOX-2specific inhibitor (IC50= 10nM) and aPPARγagonist. SC-236 supresses activator protein-1 (AP-1) through c-Jun NH2-terminal kinase. SC-236 exerts anti-inflammatory effects by suppressing ...

YN320136 CHPG 170846-74-9

CHPG is a selectivemGluR5agonist, and attenuates SO2-induced oxidative stress and inflammation throughTSG-6/NF-κBpathway in BV2 microglial cells. CHPG protects against traumatic brain injury (TBI) in vitro and ...

YN320029 AGN 192836 171102-29-7

AGN 192836 is a potent and selectiveα2 adrenergicagonist with EC50s of 8.7, 41 and 6.6nM for α2A, α2B and α2C receptor, respectively.

YN372701 Tadalafil 171596-29-5

Tadalafil is a PDE-5 inhibitor with IC50 of 1.8 nM in a cell-free assay. Tadalafil is at least 9000 times more selective for PDE5 than most of the other families of PDEs, with the exception of PDE11. It can partial inhibit...

YN372700 Nortadalafil 171596-36-4

Nortadalafil is demethyl Tadalafil, which is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hype...

YN372251 Sildenafil citrate 171599-83-0

Sildenafil Citrate, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5), is a well-tolerated and highly effective treatment for erectile dysfunction.

YN320976 Darusentan 171714-84-4

Darusentan (Lu-135252) is a selectiveendothelin receptor A(ET-A)receptorantagonist, which binds with a Ki of 1.4nM to the ET-A receptor and a Kiof 184nM to ET-B receptor, respectively with a 100-fold selectivity for ETA...

YN372532 ZD-0892 171964-73-1

ZD-0892 is a selective and potent inhibitor of aneutrophil elastasewith Kis of 6.7 and 200nM for human neutrophil elastase and porcine pancreatic elastase, respectively.

YN320698 Dehydro Olmesartan 172875-98-8

Dehydro Olmesartan is a derivative of Olmesartan. Olmesartan is anangiotensin II receptor (AT1R)antagonist and has the potential for high blood pressure study.

YN300009 Sibrafiban 172927-65-0

Sibrafiban (RO 48-3657) is the orally active, nonpeptide, double-prodrug of Ro 44-3888 and a selectiveglycoprotein IIb/IIIa receptorantagonist. Sibrafiban inhibits platelet aggregation .