YN321306 Sitaxsentan 184036-34-8

Sitaxsentan (IPI 1040; TBC-11251) is a selective endothelin A (ETA) receptor antagonist. Antihypertensive. Sitaxsentan is used in treatment of chronic heart failure.

YN360820 (S)-Lercanidipine hydrochlor... 184866-29-3

(S)-Lercanidipine hydrochloride is the S-enantiomer of Lercanidipine hydrochloride. (S)-lercanidipine hydrochloride is a potent calcium channel blocker.

YN360663 Cilobradine hydrochloride 186097-54-1

Cilobradine is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.

YN322089 5-HT3-In-1 186348-68-5

5-HT3-In-1 is extracted from patent EP0748807A1, compound example 8. It shows5-HT3inhibition activity.

YN481668 Ingliforib 186392-65-4

Ingliforib is aglycogen phosphorylaseinhibitor, with IC50s of 52, 352 and 150nM for liver, muscle and brain glycogen phosphorylase, and has cardioprotective activity.

YN321212 ZD-1611 186497-38-1

ZD-1611 is a potent, orally active, selectiveETA receptorantagonist, used for the research of ischemic stroke.

YN330596 Ginsenoside Rg5 186763-78-0

Ginsenoside Rg5 is the main component of Red ginseng. Ginsenoside blocks binding ofIGF-1to its receptor with an IC50 of ~90nM. Ginsenoside Rg5 also inhibits the mRNA expression ofCOX-2via suppression of the DNA binding ...

YN320020 TAK-024 186971-69-7

TAK-024 is aplateletinhibitor with IC50s of 31, 79 and 51nM in human, monkey and guinea pig, respectively.

YN372244 Sofigatran 187602-11-5

Sofigatran (MCC-977) is an orally activefactor IIa (thrombin)inhibitor, acts as an anticoagulant. Sofigatran is used for the research of cardiovascular disease.

YN360818 (R)-Lercanidipine hydrochlor... 187731-34-6

(R)-Lercanidipine hydrochloride is the R-enantiomer of Lercanidipine. (R)-lercanidipine hydrochloride is a calcium channel blocker.

YN480050 (±)-WS75624B 188048-45-5

(±)-WS75624B is anendothelin converting enzyme(ECE) inhibitor with an IC50 of 0.03 μg/mL.

YN370267 MAFP 188404-10-6

MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor ofcPLA2 and iPLA2. MAFP is also a potent irreversible inhibitor ofan and amide amidase.

YN300058 Eptifibatide 188627-80-7

Eptifibatide is a cyclic heptapeptide, acts as a competitive antagonist for the activated plateletglycoprotein IIb/IIIa receptor, with anti-platelet activity.

YN321494 Ozagrel sodium 189224-26-8

Sodium ozagrel (ozagrel) is a thromboxane A2 synthase inhibitor with neuroprotective properties.

YN320140 L-765314 189349-50-6

L-765314 is a potent and selectiveα1b adrenergic receptorantagonist with Kis of 5.4nM and 2.0nM for rat and human α1b adrenergic receptor, respectively.

YN373982 K134 189362-06-9

K134 is aphosphodiesterase 3(PDE3) inhibitor. TheIC50s of K134 towardPDE3A,PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 µM, respectively.

YN410045 Ezetimibe ketone 191330-56-0

Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potentNrf2activator. Ezetimibe is a potent cholesterol absorption inhibitor .

YN322074 5-HT2 antagonist 1 191592-09-3

5-HT2 antagonist 1 is a potent antagonist of5-HT2 receptor, with weakα1 adrenoceptorblocking activity.

YN340003 PD-161570 192705-80-9

PD-161570 is a potent and ATP-competitivehuman FGF-1 receptorinhibitor with an IC50 of 39.9nM and a Ki of 42nM. PD-161570 also inhibits the PDGFR,EGFR and c-Src tyrosine kinaseswith IC50 values of 310nM, 24...

YN370393 Ximelagatran 192939-46-1

Ximelagatran (H 376/95) is an orally activethrombininhibitor that selectively and competitively inhibits both free and clot-boundthrombin. Ximelagatran is an anticoagulant agent with a rapid onset of anticoagulant effect, predictable...