YN360164 Eniporide hydrochloride 211813-86-4

Eniporide hydrochloride (EMD-96785 hydrochloride) is a potentNa+/H+exchange inhibitor.

YN372687 Dabigatran ethyl ester hydroc... 211914-50-0

Dabigatran ethyl ester hydrochloride is a potent inhibitor of ribosyldihydronicotinamide dehydrogenase (NQO2) with an IC50 value of 0.8μM and athrombininhibitor.

YN370180 Dabigatran 211914-51-1

Dabigatran (BIBR 953), an oral anticoagulant, is a reversible, potent, competitive directthrombininhibitor (Ki=4.5nM). Dabigatran (BIBR 953) also inhibits thrombin-induced platelet aggregation (IC50=10nM).

YN480226 Dabigatran etexilate 211915-06-9

Dabigatran Etexilate is the prodrug of dabigatran, a potent, nonpeptidic small molecule that specifically and reversibly inhibits both free and clot-bound thrombin by binding to the active site of the thrombin molecule.

YN360310 MRS 1523 212329-37-8

MRS 1523 is a potent and selectiveadenosine A3receptorantagonist with Ki values of 18.9nM and 113nM forhuman and rat A3receptors, respectively. In rat this corresponds to selectivities of 140- and 18-fold vs A1 and A2Arec...

YN320750 ABT-546 212481-66-8

ABT-546 (A-216546) is a potent, highly selective and activeendothelin ETAreceptorantagonist with a Ki of 0.46nM for [125I]endothelin-1 binding to clonedhuman endothelin ETA. ABT-546 is ＞25,000-fold more selective for theE...

YN440111 RK-24466 213743-31-8

RK-24466 (KIN 001-51) is a potent and selective inhibitor of Lck that inhibits two constructs of the human lck kinase, lck (64-509) and lckcd with IC50 of < 0.001 μM and 0.002 μM, respectively.

YN330360 1400W Dihydrochloride 214358-33-5

1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase(iNOS).

YN350162 RWJ-67657 215303-72-3

RWJ-67657 (JNJ 3026582) is an orally active and selective p38α and p38β MAPK inhibitor with IC50s of 1 and 11μM, respectively. RWJ-67657 displays no activity at p38γ and p38δ, and exhibits cardio protective effe...

YN330295 Succinobucol 216167-82-7

AGI-1067 is a novel, phenolic, intra- and extracellular antioxidant that inhibits the expression of a number of proinflammatory genes involved in atherosclerosis.

YN484042 Apelin-13 217082-58-1

Apelin-13 is the endogenous lig and of the orphan G protein-coupled receptor APJ, activates APJ receptor with an EC50value of 0.37nM in CHO cells.

YN483821 [Pyr1]-Apelin-13 217082-60-5

[Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist.

YN370044 K-604 dihydrochloride 217094-32-1

K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC50 of 0.45±0.06μM.

YN480084 SCH00013 217963-18-3

SCH00013 is a cardiotonic agent that primarily acts via an increase in myofibrillar Ca++ sensitivity, have a significant Ca(2+)sensitizing effect at pH 7.2 to 7.4. In vitro: SCH00013 at 10-4 M increased the systolic cell shorteni...

YN320507 Dabuzalgron 219311-44-1

Dabuzalgron (Ro 115-1240) is an orally active and selectiveα-1A adrenergic receptoragonist for the treatment of urinary incontinence. Dabuzalgron protects against Doxorubicin-induced cardiotoxicity by preserving mitochondrial functi...

YN370514 Mitochondrial fusion promoter... 219315-22-7

Mitochondrial fusion promoter M1 is a mitochondrial dynamic modulator. Mitochondrial fusion promoter M1 preserves the mitochondrial function and promotes cellular respiration. Mitochondrial fusion promoter M1 alleviates cardiac and...

YN330076 PMX-53 219639-75-5

PMX-53 is a potent CD88 (C5aR) antagonist and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an agonist of Mas-related gene 2 (MrgX2...

YN320172 Sulamserod 219757-90-1

Sulamserod is a5-HT4 receptorantagonist, with antiarrhythmic activities.

YN360436 OR-1896 220246-81-1

OR-1896 is an active long-lived metabolite of Levosimendan. OR-1896 is a highly selectivephosphodiesterase (PDE) IIIisoform inhibitor and a powerful vasodilator. OR-1896 can openATP-sensitive K+channels and has Ca2+-sen...

YN360019 Naminidil 220641-11-2

Naminidil is a cyanoguanidine KATP opener.