Chemical structure
Cat.No.
Product Name
CAS no.
Target
YN480227 Dabigatran etexilate mesylate 872728-81-9
Dabigatran etexilate mesylate (Pradaxa, BIBR 1048MS, Dabigatran etexilate methanesulfonate) is an orally active prodrug of Dabigatran which is a reversible and selective, direct thrombin inhibitor (DTI). Dabigatran sele...
YN300035 Omecamtiv mecarbil 873697-71-3
Omecamtiv mecarbil (CK-1827452) is a specific cardiac myosin activator and a clinical drug for left ventricular systolic heart failure. Phase 2.
GSK-25 is a potent, selective and orally bioavailableROCK1inhibitor (IC50=7nM). GSK-25 maintains good selectivity against a panel of 31 kinases (>100 fold), as well as RSK1 and p70S6K (RSK1: IC50=398nM, p70S6K:...
YN361010 Dimethyl lithospermate B 875313-64-7
Dimethyl lithospermate B (dmLSB) is a selectiveNa+channel agonist. Dimethyl lithospermate B slows inactivation of sodium current (INa), leading to increased inward current during the early phases of the action potential (AP).
YN370910 Anacetrapib 875446-37-0
Anacetrapib (MK0859) is a potent, selective, reversible rhCETP and mutant CETP(C13S) inhibitor with IC50 of 7.9 nM and 11.8 nM, increases HDL-C and decreases LDL-C, does not increase aldosterone or blood pressure. P...
RF9 is a potent and selectiveNeuropeptide FF receptorantagonist, with Ki values of 58 and 75nM forhNPFF1R and hNPFF2R, respectively.
JNJ 303 is a potentIKsblocker with an IC50 value of 64nM. JNJ 303 does not have any effects on other cardiac channels at concentrations of 3.3μM for INa, Ica, Ito, and IKr. JNJ 303 induces QT-prolongations and ca...
SC99 is an orally active, selectiveSTAT3inhibitor targeting JAK2-STAT3 pathway. SC99 docks into the ATP-binding pocket of JAK2. SC99 inhibits phosphorylation of JAK2 and STAT3 with no effects on the other kin...
GW9508 is a potent and selective agonist for FFA1 (GPR40) with pEC50 of 7.32, 100-fold selective against GPR120, stimulates insulin secretion in a glucose-sensitive manner.
YN483016 Piperlotine C 886989-88-4
Piperlotine C is an alkaloid isolated fromPiper lolot, with anti-platelet aggregation induced by arachidonic acid, and theIC50is 26.6 µg/mL.
YN481213 3-Oxo Atorvastatin 887196-30-7
3-Oxo Atorvastatin is an impurity of 3-Oxo Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids.
YN322084 CB1 antagonist 1 890037-68-0
CB1 antagonist 1 is an antagonist ofCB1 receptor, used in the research of metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, gastrointestinal disorders, and cardiovascular conditions.
LUF6000 is an orally active allosteric modulator of theA3 adenosine receptor. LUF6000 has potent anti-inflammatory effect.
TP-10 is a PDE10A inhibitor with IC50 of 0.8nM.
JI-101 is an orally available multi-kinase inhibitor ofVEGFR2，PDGFRβ and EphB4with potent anti-cancer activity.
YN361047 Tertiapin-Q 910044-56-3
Tertiapin-Q is a highly selective blocker ofGIRK1/4heterodimer and ROMK1(Kir1.1).
YN1710005 BAY 60-6583 910487-58-0
BAY 60-6583 is a potent and high-affinity agonist ofadenosine A2Breceptor (EC50= 3nM) over A1, A2A, and A3 receptors. BAY 60-6583 binds to mouse, rabbit, and dog A2BAR with Ki values of 750nM, 340nM and 330nM,...
YN321358 Felypressin acetate 914453-97-7
Felypressin acetate (PLV-2 acetate) is a non-catecholamine vasoconstrictor and avasopressin 1agonist. Felypressin acetate is widely used in dental procedures.
YN380018 (2-Chloropyridin-4-yl)methana... 916210-98-5
(2-Chloropyridin-4-yl)methanamine hydrochloride is a selectiveLOXL2inhibitor with an IC50 of 126nM.
AZD1283 is a potent antagonist of the P2Y12 receptor with EC50 of 3.0 ug/kg/min, TI >10; with binding IC50 of 11nM. AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregat...
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