YN250042 BRD-6929 849234-64-6

BRD-6929 (Cpd-60) is a brain-penetrant, selective inhibitor of HDAC1 and HDAC2(IC50= 1 and 8nM), extracted from patent US2018360927. BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 with Kiof 0.2 ...

YN372705 Alogliptin Benzoate 850649-62-6

Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.

YN450103 GSK269962A 850664-21-0

GSK269962A (GSK 269962) is a potentROCKinhibitor with IC50s of 1.6 and 4nM for recombinant humanROCK1 and ROCK2respectively. GSK269962A has anti-inflammatory and vasodilatory activities.

YN320680 MK-0354 851776-28-8

MK-0354 is a partial agonist of GPR109a receptor, for hGPR109a/ mGPR109a with EC50 of 1.65/1.08μM, showed no activation of GPR109b.

YN360805 Ropivacaine mesylate 854056-07-8

Ropivacaine Mesilate is the mesylate form of ropivacaine, which is a member of the amino amide class of local anesthetics.

YN370962 Kurarinol 855746-98-4

Kurarinol is a flavanone found in the root ofSophora flavescens. Kurarinol is a competitivetyrosinaseinhibitor, with IC50 of 0.1μM for mushroom tyrosinase.

YN330291 Choline Fenofibrate 856676-23-8

Choline fenofibrate is a newly developed choline salt of fenofibric acid, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity that acts as an PPARα agonist.

YN300029 (-)-Blebbistatin 856925-71-8

(-)-Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of ~2 μM in cell-free assays, does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mito...

YN340042 BMS-690514 859853-30-8

BMS-690514 is a potent and orally active inhibitor ofEGFR and VEGFR; hasIC50s of 5, 20 and 60nM for EGFR, HER 2 and HER 4, respectively.

YN483839 M617 860790-38-1

M617 is a selective galanin receptor 1(GAL1)agonist, with Kis of 0.23 and 5.71nM for GAL1 and GAL2, respectively. M617, acting through its central GAL1, can promote GLUT4 expression and enhance GLUT4 content in...

YN320903 Azilsartan medoxomil 863031-21-4

Azilsartan Medoxomil is a potent angiotensin II type 1 (AT1) receptor antagonist, inhibits the RAAS, with an IC50 of 2.6 nM, exhibits >10,000-fold selectivity over AT2.

YN360151 Zoniporide hydrochloride hydr... 863406-85-3

Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor ofsodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride hydrate inhibits human NHE-1 (IC50=14nM), and has >150-fold selectivity v...

YN321038 Revefenacin 864750-70-9

Revefenacin (TD-4208) is a potent, lung-selective, long-acting muscarinic antagonist that may be for the treatment of respiratory disease.

YN480717 Aladorian 865433-00-7

Aladorian (ARM036) is a benzothiazepine derivative, with anti-arrhythmia effect. Aladorian is used for the research of heart failure and catecholaminergic polymorphic ventricular tachycardia.

YN372684 5-R-Rivaroxaban 865479-71-6

5-R-Rivaroxaban is (R)-enantiomer of Rivaroxaban. Rivaroxaban (BAY 59-7939) is a highly potent and selective, directFactor Xa(FXa) inhibitor, achieving a strong gain in anti-FXa potency (IC500.7nM;Ki0.4nM).

YN310059 CMPD101 865608-11-3

CMPD101 is a potent, highly selective and membrane-permeable small-molecule inhibitor ofGRK2/3with IC50 of 18nM and 5.4nM, respectively. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKC...

YN320994 PRX-08066 866206-54-4

PRX-08066 is a selective 5-hydroxytryptamine receptor 2B (5-HT2BR, IC50= 3.4nM) antagonist that causes selective vasodilation of pulmonary arteries.

YN450021 ROCK-IN-2 867017-68-3

Azaindole 1 (TC-S 7001) is a selective Rho-associated protein kinase (ROCK) inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2 in an ATP-competitive manner.

YN481405 Tecarfarin 867257-26-9

Tecarfarin (ATI-5923) is an orally active and non-competitive vitamin K epoxide reductase (VKOR) antagonist, and impairs the activation of the vitamin K-dependent clotting factors II, VII, IX and X. Tecarfarin has t...

YN321901 Obestatin(rat) 869705-22-6

Obestatin(rat), encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous lig and of G-pr...