YN480749 Resmetirom 920509-32-6

Resmetirom is a liver-directed, orally active, selective thyroid hormone receptor β(THR-β) agonist with an EC50 of 0.21 μM,shows 28-fold selective for THR-β over THR-α in a functional assay.

YN360257 GSK1702934A 924377-85-5

GSK1702934A is a selectiveTRPC3agonist. GSK1702934A modulates cardiac contractility and f arrhythmogenesis by activation of TRPC3.

YN481427 S107 927871-76-9

S107 is a Type 1 ryanodine receptor (RyR1) stabilizer that binds RyR1 and enhances the binding affinity of calstabin-1.

YN320781 trans-R-138727MP 929211-64-3

trans-R-138727MP (Prasugrel metabolite R-138727MP) is the activemetabolite derivativeof Prasugrel (HY-15284). Prasugrel, a thienopyridine and prodrug, inhibits platelet function. Prasugrel is an orally active and potentP2Y...

YN321243 TY-52156 934369-14-9

TY-52156 is a potent and selectiveS1P3receptor antagonist with aKivalue of 110nM.

YN450152 ROCK-IN-1 934387-35-6

ROCK-IN-1 is a potent inhibitor ofROCK, with an IC50 of 1.2nM for ROCK2.

YN320414 Elinogrel 936500-94-6

Elinogrel (PRT060128) is a potent, direct acting, competitive, and reversible plateletP2Y12antagonist (IC50=20nM). It is orally and intravenously available and has potent antiplatelet effects.

YN321181 LCZ696 936623-90-4

Sacubitril/valsartan (LCZ696), consisting of valsartan and sacubitril in 1:1 molar ratio, is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure. Phase 3.

YN372556 BMS-795311 939390-99-5

BMS-795311 is a potent and orally bioavailable inhibitor ofcholesteryl ester transfer protein (CETP), with IC50s of 4nM in an enzyme-based scintillation proximity assay (SPA) and 0.22μM in a human whole plasma assay (hWP...

YN370994 BI-1935 940954-41-6

BI-1935 is a potentsoluble epoxide hydrolase (sEH)inhibitor for diseases related to cardiovascular disease.

YN360684 GSK1016790A 942206-85-1

GSK1016790A is a potent and selectivetransient receptor potential vanilloid 4 (TRPV4)channel agonist. GSK1016790A can elicit Ca2+influx and elevate intracellular Ca2+in HEK cells.

YN300017 Danegaptide Hydrochloride 943133-81-1

Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a potent, selective and orally activegap-junctionmodifier with an antiarrhythmic effect.

YN300016 Danegaptide 943134-39-2

Danegaptide (GAP-134) is a potent, selective and orally activegap-junctionmodifier with an antiarrhythmic effect.

YN320144 CYM-5541 945128-26-7

CYM-5541 (ML249) is an selective and allostericS1P3receptor agonist with anEC50between 72 and 132nM.

YN360934 Ophiopogonin D 945619-74-9

Ophiopogonin D, isolated from the tubers ofOphiopogon japonicus, is a rare naturally occurring C29steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocatio...

YN370442 Apararenone 945966-46-1

Apararenone (MT-3995) is a novel non-steroidalmineralocorticoid receptorantagonists under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.

YN372352 LP-533401 945976-43-2

LP-533401 is aTryptophan hydroxylase 1inhibitor that regulates serotonin production in the gut.

YN360330 ML365 947914-18-3

ML365 is a novel selective small molecule inhibitor of the TASK1 or potassium channel, subfamily K, member 9 (KCNK3) .

YN330234 Sodium formononetin-3'-sulfon... 949021-68-5

Sodium formononetin-3'-sulfonate (Sul-F) is a water-sol. derivate of formononetin. Research results showed that treatment with Sul-F significantly prevented the elevation of ST-segment level, decreased the contents of creatine kina...

YN310079 Delcasertib 949100-39-4

Delcasertib (KAI-9803) is a potent and selective δ-protein kinase C (δPKC) inhibitor. Delcasertib (KAI-9803) could ameliorate injury associated with ischemia and reperfusion in animal models of acute myocardial infarction ...