YN483050 Platycoside E 237068-41-6

Platycoside E is a platycodigenin-type saponin isolated from the root ofPlatycodon gr and iflorumwithhaemolytic activity and adjuvant potential. Platycoside E promotes the production of the sera OVA-specificIgG2a and IgG2bantib...

YN360022 FR183998 free base 239440-20-1

FR183998 free base is a potent Na+/H+- exchangeinhibitor, with IC50s of 0.3nM, 3.1nM and 6.5nM by measurement of pH ichange in rat lymphocytes, rat and human platelets, respectively.

YN330683 Reslizumab 241473-69-8

Reslizumab (Sch 55700) is humanized monoclonal antibodies that targetinterleukin-5 (IL-5)for the treatment of eosinophilic asthma. Reslizumab is effective in neutralizing the function ofIL-5. Reslizumab inhibitsIL-5-dependent cell...

YN330102 Resatorvid 243984-11-4

Resatorvid (TAK-242) is a selectiveToll-like receptor 4 (TLR4)inhibitor. Resatorvid inhibitsNO, TNF-R and IL-6production with IC50s of 1.8nM, 1.9nM and 1.3nM, respectively. Resatorvid downregulates expression of TL...

YN373826 CTTHWGFTLC, CYCL... 244082-19-7

CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor formatrix metalloproteinases MMP-2 and MMP-9. TheIC50 value for MMP-9 is ~8μM.

YN481733 LR-90 245075-84-7

LR-90 is anadvanced glycation end product (AGE)inhibitor, inhibits inflammatory responses in human monocytes. LR-90 is also used in the research of diabetic animal model.

YN484136 GAD65 (206-220) 245124-26-9

GAD65 (206-220) is glutamic acid decarboxylase (GAD) 65-derived peptide, corresponding to residues 180-188. GAD65 is presented to T cells in association with I-Ag7 MHC class II molecules and a major pancreatic antigens ta...

YN330123 NFAT Transcription Facto... 245747-71-1

NFAT Transcription Factor Regulator-1 is anIL-2 synthesisinhibitor with an IC50 of 182nM.

YN483931 Tyrosine Protein Kinase JA... 247171-44-4

Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide corresponding to amino acids 475 to 491 of mouse JAK2.

YN480513 KRN2 248260-75-5

KRN2 is a selective inhibitor ofnuclear factor of activated T cells (NFAT5), with an IC50 of 100nM. KRN2 has potential to treat NFAT5-mediated Chronic Arthritis.

YN410037 Laquinimod 248281-84-7

Laquinimod is a potent immunomodulator. Phase 3.

YN480064 Paquinimod 248282-01-1

Paquinimod is aS100A9 inhibitor, which prevents S100A9 binding toTLR-4.

YN483816 NFAT Inhibitor 249537-73-3

NFAT Inhibitor (VIVIT peptide) is a cell-permeable peptide inhibitor ofnuclear factor of activated Tcells (NFAT)that selectively inhibits calcineurin-mediated dephosphorylation ofNFAT.

YN480504 13-cis-N-[4-(Ethoxycarbonyl)... 251441-94-8

13-cis-N-[4-(Ethoxycarbonyl)phenyl]retinamide is a derivative of Retinoic acid.

YN300001 A-205804 251992-66-2

A-205804 is a potent and selective inhibitor of E-selectin and ICAM-1 expression with IC50 of 20 nM and 25 nM respectively.

YN300083 ICAM-1-IN-1 251994-14-6

ICAM-1-IN-1 is a potent and selective inhibitor ofE-selectin and ICAM-1with IC50 values of 7 and 5nM, respectively.

YN481556 CH 5450 252557-97-4

CH 5450 (Z-Ile-Glu-Pro-Phe-Ome) is a human chymase inhibitor.

YN350118 5Z-7-Oxozeaenol 253863-19-3

5Z-7-Oxozeaenol is a natural anti-protozoan compound from fungal origin, acting as a potent irreversible and selective inhibitor ofTAK1 and VEGF-R2, with IC50s of 8nM and 52nM, respectively.

YN330213 MCC950 sodium 256373-96-3

MCC950 sodium salt is a potent, selective inhibitor of NLRP3 with IC50 of 7.5 nM in BMDMs but not the AIM2, NLRC4 or NLRP1 inflammasomes.

YN320581 BAY 41-2272 256376-24-6

BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.