YN310127 Sirt2-IN-1 1862238-00-3

Sirt2-IN-1 (Compound 9) is asirtuin 2(Sirt2) inhibitor with an IC50 of 163nM.

YN321996 Protease-Activated Receptor... 1872435-09-0

Protease-Activated Receptor-3 (PAR-3) (1-6), human is a proteinase-activated receptor (PAR-3) agonist peptide.

YN370892 XY018 1873358-87-2

XY018 is a potentROR-γ-selective antagonist. XY018 inhibits ROR-γ constitutive activity in 293T cells with high potency (EC50, 190nM). XY018 binds to the ROR-γ hydrophobic lig and binding domain (LBD).

YN320097 CXCR2-IN-1 1873376-49-8

CXCR2-IN-1 is a central nervous system penetrantCXCR2antagonists with apIC50 of 9.3.

YN480612 Ly93 1883528-69-5

Ly93 is a selective and orally activesphingomyelin synthase 2 (SMS2)inhibitor, with an IC50 of 91nM.

YN310322 NI-57 1883548-89-7

NI-57 is an inhibitor of bromodomain and plant homeodomain finger-containing (BRPF) famlily of proteins, with IC50s of 3.1, 46 and 140nM for BRPF1, BRPF2 (BRD1) and BRPF3, respectively.

YN370321 Liarozole dihydrochloride 1883548-96-6

Liarozole dihydrochloride (R75251; R85246) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor ofestrogen(via inhibition of aromatase) and testicular and rogen synthesis (inhibition of 17 ,...

YN360203 AM-0902 1883711-97-4

AM-0902 is a potent, selective transient receptor potential A1 (TRPA1) antagonist with IC50s of 71 and 131nM forrTRPA1 and hTRPA1, respectively.

YN320608 Terlipressin acetate 1884420-36-3

Terlipressin acetate is a vasopressin analogue with potent vasoactive properties. Terlipressin acetate is a highly selectivevasopressin V1 receptoragonist that reduces the splanchnic blood flow and portal pressure and controls acute ...

YN370797 Olutasidenib 1887014-12-1

Olutasidenib is a potent, orally bioavailable, brain penetrant and selective mutant IDH1 (mIDH1) inhibitor with IC50 of 21.1 nM, 114 nM for IDH1-R132H, IDH1-R132C, respectively.

YN350109 Salicortin 1887055-63-1

Salicortin, a phenolic glycoside, has been isolated from many plants such asPopulus and Salixspecies. Salicortin inhibits osteoclast differentiation and bone resorption by down-regulatingJNK and NF-κB/NFATc1signaling pathwa...

YN370585 PF-06747711 1892576-58-7

PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known asRORγt) inverse agonist, with an IC50 of 4.1nM. Anti-skin inflammatory activity.

YN320527 AZD9567 1893415-00-3

AZD9567 (compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model ...

YN5340001 LY3200882 1898283-02-7

LY 3200882 is a potent, highly selective inhibitor of TGF-β receptor type 1 (TGFβRI). It potently inhibits TGFβ mediated SMAD phosphorylation in vitro in tumor and immune cells and in vivo in subcutaneous tumors ...

YN330159 Danicopan 1903768-17-1

Danicopan (ACH-4471), a selective and orally active small-moleculefactor Dinhibitor, shows high binding affinity to human Factor D withKdvalue of 0.54nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC...

YN480218 BT-11 1912399-75-7

BT-11 is an orally active lanthionine synthetase C-like 2 (LANCL2) binding compound for treating inflammatory bowel disease (IBD) (Kd value of 7.7 µM).

YN350092 MW-150 hydrochloride 1923773-01-6

MW-150 hydrochloride (MW01-18-150SRM hydrochloride) is a selective, CNS penetrant, and orally active inhibitor ofp38α MAPKwith a Ki of 101nM. MW-150 hydrochloride (MW01-18-150SRM hydrochloride) inhibits the ability...

YN330030 YKL-05-099 1936529-65-5

YKL-05-099 is an inhibitor of salt-inducible kinase (SIK) with IC50 of ~10 nM, ~40 nM and ~30 nM for SIK1, SIK2 and SIK3, respectively.

YN300026 BOP sodium 1947348-42-6

BOP sodium is a potent and selective dualα9β1/α4β1 integrininhibitor withKdvalues in the picomolar range. BOP sodium shows the rapid and preferential mobilization of hematopoietic stem cell (HSC) and progenitors. BOP ...

YN480697 GSK 366 1953157-39-5

GSK 366 is a potentkynurenine-3-monooxygenase (KMO)inhibitor with IC50s of 2.3nM and 0.7nM for human KMO and P. fluorescens-KMO (Pf-KMO), respectively.