YN321239 Adriforant hydrochloride 2096455-90-0

Adriforant hydrochloride (PF-3893787 hydrochloride) is a novelhistamine H4 receptorantagonist binding affinity (Ki=2.4nM) and is also a functional (Ki=1.56nM) antagonist.

YN480930 Kgp-IN-1 hydrochloride 2097865-47-7

Kgp-IN-1 hydrochloride is anarginine-specific gingipain(Rgp) inhibitor extracted from patent WO2017201322A1, compound 13-R.

YN340026 TyK2-IN-2 2098466-94-3

TyK2-IN-2 (Compoud 18) is a potent and selectiveTYK2inhibitor with IC50s of 7nM, 0.1μM and 0.05μM forTYK2 JH2,IL-23 and IFNα, respectively. TyK2-IN-2 also inhibitsphosphodiesterase 4 (PDE4)with an IC50...

YN410052 BIZ 114 2099120-74-6

BIZ 114 (Example 11) is a fatty acid derivative and potent inhibits the TNF-α activatedNF-κΒpathway. BIZ 114 has the potential to prevent and / or treat ophthalmic disorders such as retinal degenerative disorders and oc...

YN320456 AZ3451 2100284-59-9

AZ3451 is a potentprotease-activated receptor-2 (PAR2)antagonist with IC50 of 23nM.

YN370901 AZD-0284 2101291-07-8

AZD-0284 is a selective inverse agonist of the nuclear receptorRORγ. AZD-0284 has the potential for plaque psoriasis vulgaris and respiratory tract disorders treatment.

YN330202 HPGDS inhibitor 2 2101626-26-8

HPGDS inhibitor 2 is a highly potent and selectivehematopoietic prostagl and in D synthase (H-PGDS)inhibitor with an IC50 of 9.9nM.

YN270140 DRI-C21045 2101765-81-3

DRI-C21045 (compound 10) is a potent and selective inhibitor of theCD40-CD40Lcostimulatory protein-protein interaction (PPI) with an IC50 of 0.17 µM. DRI-C21045 shows concentration-dependent inhibition of the activatio...

YN370288 IPN-60090 dihydrochloride 2102101-72-2

IPN-60090 dihydrochloride is an orally bioavailable and selective inhibitor ofGLS1 (the kidney-type glutaminase), an important enzyme for metabolic energy production. IPN-60090 dihydrochloride can be used in the research of GLS...

YN330047 CU-CPT17e 2109805-75-4

CU-CPT17e is a potent multi-Toll-like receptor(TLR) agonist that activatesTLR3,TLR8, and TLR9.

YN330157 JC-171 2112809-98-8

JC-171 is a selectiveNLRP3inflammasome inhibitor, with an IC50 of 8.45μM for inhibiting LPS/ATP-induced interleukin-1β (IL-1β) release from J774A.1 macrophages.

YN330169 BMS-1001 hydrochloride 2113650-04-5

BMS-1001 hydrochloride is an orally active humanPD-L1/PD-1immune checkpoint inhibitor. BMS-1001 hydrochloride exhibits low-toxicity in cells.

YN480461 BAY-677 2117404-84-7

BAY-677 is an inactive control for BAY-678. BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase(HNE), with an IC50 of 20nM. BAY-678 is also nominated as a...

YN1710026 PSB 0777 ammonium 2122196-16-9

PSB 0777 ammonium is a potent and selective adenosineA2Areceptor full agonist with Ki values of 44.4nM, 360nM for rat and human A2Areceptors, respectively. PSB 0777 ammonium has Kivalues of ≥10000nM, 541nM for rat and ...

YN250546 Tenofovir diphosphate triethy... 2122333-63-3

Tenofovir diphosphate triethylamine (TFV-DP triethylamine) is a competitiveDNA polymerasesinhibitor (with respect to dATP) and a substrate of HIV type 1 (HIV-1)reverse transcriptase(RT).

YN340107 PF-06826647 2127109-84-4

PF-06826647 is an orally active and selectiveTYK2inhibitor (IC50=17nM), which binds to TYK2 catalytically active JH1 domain. PF-06826647 displays selectivity for TYK2 over JAK1 (IC50=383nM) and JAK2 (74nM). P...

YN340108 Tyk2-IN-9 2127109-85-5

Tyk2-IN-9 is a potent,selective and specific inhibitor ofJAK kinases, inhibits Tyk2, JAK1 and JAK2 with IC50 values of 6nM, 21nM and 6nM, respectively. Tyk2-IN-9, example 19, is extracted from patent US20172405...

YN420088 AZD3458 2132961-46-5

AZD3458 is a potent and remarkably selectivePI3Kγinhibitor with pIC50s of 9.1, 5.1, <4.5, and 6.5 forPI3Kγ,PI3Kα,PI3Kβ, and PI3Kδ, respectively.

YN330675 Human PD-L1 inhibitor IV 2135542-83-3

Human PD-L1 inhibitor IV, a polypeptide, is a competitivehuman PD-1 proteininhibitor with aKdvalue of 1.38μM. Human PD-L1 inhibitor IV inhibits the interaction of hPD-1/hPD-L1.

YN330676 Human PD-L1 inhibitor II... 2135542-84-4

Human PD-L1 inhibitor III is a human PD-L1 inhibitor.