YN370847 LKY-047 1954681-29-8

LKY-047, a Decursin derivative, is a potent and selective reversible competitivecytochrome P45022J2 (CYP2J2)inhibitor with an IC50 of 1.7μM. LKY-047 is inactive against other human P450s, such as CYPs 1A2, 2A6, 2B6...

YN270024 RIPA-56 1956370-21-0

RIPA-56 is a highly-potent, selective, and metabolically stable RIP1 (RIPK1) inhibitor.

YN430071 Thalidomide-O-amido-PEG2-... 1957235-75-4

Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase lig and -linker conjugate that incorporates the Thalidomide based cereblon lig and and 2-unit PEG linker used inPROTACtechnology.

YN440218 TGFβRI-IN-2 1976038-41-1

TGFβRI-IN-2 (compound 18) is a potent, selective and orally active(Activin-Like Kinase 5) ALK 5inhibitor withpIC50 and pEC50values of 7.6 and 6.63, respectively. TGFβRI-IN-2 can produce observed cardiac toxicit...

YN380032 PAT-1251 2007885-39-2

PAT-1251 is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC5...

YN300028 Integrin modulator 1 2023788-32-9

Integrin modulator 1 is a potent and selectiveα4β1 integrinagonist, with an IC50 of 9.8nM for RGD-binding α4β1. Integrin modulator 1 increases cell adhesion mediated by α4β1 integrin, with an EC50 of 12.9nM.

YN321120 Loteprednol Etabonate D5 2026643-11-6

Loteprednol Etabonate D5 is a deuterium labeled Loteprednol etabonate. Loteprednol etabonate (LE) is an orally active "soft" steroid belonging to a unique class of glucocorticoids. Loteprednol etabonate (LE) exhibits anti-inflamma...

YN482336 HKOCl-4m 2031170-88-2

HKOCl-4m is a selective and mitochondria-targeting rhodol-based fluorescent probe for monitoring mitochondrial hypochlorous acid (HOCl).

YN350014 AX-15836 2035509-96-5

AX-15836 is a potent and selectiveERK5inhibitor with an IC50 of 8nM.

YN360306 GLPG2451 2055015-61-5

GLPG2451 is acystic fibrosis transmembrane conductance regulator (CFTR)potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1nM.

YN321531 Hydroxyzine D4 2070014-84-3

Hydroxyzine D4 is deuterium labeled Hydroxyzine. Hydroxyzine is a heterocyclichistamine H1-receptorantagonist. Hydroxyzine has anticholinergic, anxiolytic and analgesic properties.

YN330215 IFN alpha-IFNAR-IN-1... 2070014-98-9

IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM).

YN321114 Cetirizine D8 dihydrochlorid... 2070015-04-0

Cetirizine D8 dihydrochloride is a deuterium labeled Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamineH1-receptorantagon...

YN482342 N-acetyl Dapsone (D4') 2070015-28-8

N-acetyl Dapsone (D4') is the deuterium labeled N-acetyl Dapsone, which is a metabolite of Dapsone.

YN310035 GSK4028 2079886-19-2

GSK4028 is the enantiomeric negative control of GSK4027, which is a PCAF/GCN5 bromodomain chemical probe, thepIC50 of GSK4028 is 4.9 in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.

YN310034 GSK 4027 2079896-25-4

GSK 4027 is a chemical probe for thePCAF/GCN5 bromodomain with an pIC50 of 7.4±0.11 for PCAF in a time-resolved fluorescence resonance energy transfer (TR-FRET) assay.

YN420065 AZD1390 2089288-03-7

AZD1390 is a first-in-class orally available and CNS penetrant ATM inhibitor with an IC50 of 0.78 nM in cells and >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity ...

YN480617 QM385 2093421-02-2

QM385 is a potentsepiapterin reductase (SPR)inhibitor with an IC50 of 1.49nM, which blocks T-cell proliferation and autoimmunity at nanomolar potency and with good oral bioavailability.

YN440152 ARQ 531 2095393-15-8

ARQ 531 is a reversible non-covalent inhibitor of Bruton’s Tyrosine Kinase (BTK), with IC50s of 0.85 nM and 0.39 nM for WT BTK and C481S BTK, respectively

YN290111 3'-Azido-3'-deoxy-5-fluorocyt... 2095417-18-6

3'-Azido-3'-deoxy-5-fluorocytidine (Compound 12) is a cytidine derivative.