YN330128 diABZI STING agonist-... 2138299-33-7

diABZI STING agonist-1 is a selective stimulator of interferon genes(STING)receptor agonist, with EC50s of 130, 186nM for human and mouse, respectively.

YN330129 diABZI STING agonist-... 2138299-34-8

diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes(STING)receptor agonist, with EC50s of 130, 186nM for human and mouse, respectively.

YN250208 ABBV-744 2138861-99-9

ABBV-744 is a BDII-selective BET bromodomain inhibitor that inhibits BRD2, BRD3 and BRD4. It is developed for treating AML and cancers.

YN340079 PF-06700841 P-Tosylate 2140301-96-6

PF-06700841 P-Tosylate is a potent dualJanus kinase 1 (JAK1) and TYK2inhibitor with IC50s of 17nM and 23nM, respectively. PF-06700841 P-Tosylate also inhibitsJAK2 and JAK3with IC50s of 77nM and 6.49μM, resp...

YN270073 RIPK-IN-4 2141969-56-2

RIPK-IN-4 is a potent and selectiveRIPK2inhibitor with excellent oral bioavailability, and has an IC50 of 3nM.

YN320482 AS2717638 2148339-28-8

AS2717638 is an oral active and selectivelysophosphatidic acid receptor 5 (LPA5)antagonist, with an IC50 of 38nM for hLPA5. AS2717638 also significantly improves PGE2-, PGF2α-, and AMPA-induced allodynia.

YN371559 Autotaxin-IN-3 2156655-68-2

Autotaxin-IN-3 is aAutotaxin(ATX)inhibitor with an IC50 of 2.4nM, compound 33, sourced from patent WO2018212534A1.

YN371383 DJ001 2161305-12-8

DJ001 is a highly specific, selective and non-competitiveprotein tyrosine phosphatase-σ (PTPσ)inhibitor with an IC50 of 1.43μM. DJ001 displays no inhibitory activity against other phosphatases, with only modest inhibitory act...

YN371011 BI-2545 2162961-71-7

BI-2545 is a potentautotaxin (ATX)inhibitor that significantly reduces LPA, with IC50s of 2.2nM and 3.4nM for human ATX and rat ATX, respectively.

YN330112 CU-CPT9b 2162962-69-6

CU-CPT9b is a specificTLR8antagonist, with an IC50 of 0.7nM. CU-CPT9b shows high binding affinity towards TLR8 with aKdof 21nM.

YN330120 CU-CPT-9a 2165340-32-7

CU-CPT-9a is a specificTLR8antagonist, with an IC50 of 0.5nM.

YN481268 Cystathionine-γ-lyase-IN-1 2165706-30-7

Cystathionine-γ-lyase-IN-1 is a selectivecystathionine γ-lyase (CSE)enzyme inhibitor with an IC50 of 6.3μM.

YN330167 YKL-06-061 2172617-15-9

YKL 06-061 is a potent and selective salt-inducible kinase (SIK) inhibitor with IC50 of 6.56 nM, 1.77 nM and 20.5 nM for SIK1, SIK2 and SIK3, respectively.

YN330227 YKL-06-062 2172617-16-0

YKL-06-062 is a second-generationsalt-inducible kinase (SIK)inhibitor with an IC50 of 2.12nM/1.40nM/2.86nM, respectively. YKL-06-062 is the structural analog of YKL-06-062.

YN320459 LIT-927 2172879-52-4

LIT-927 is a novel neutraligand of CXCL12 with Ki value of 267 nM for inhibition of Texas red-labeled CXCL12 (CXCL12-TR) binding. It shows high selectivity toward CXCL12 vs other chemokines also involved in a...

YN480969 Vanin-1-IN-1 2173134-00-2

Vanin-1-IN-1 is an inhibitor of vanin-1 enzyme which is a cell surface associated, giycosyiphosphatidyS inositol (GPi) anchored protein and plays an important role in metabolism and inflammation.

YN270199 PK68 2173556-69-7

PK68 is a potent and selective type II inhibitor ofreceptor-interacting kinase 1 (RIPK1)with an IC50 of ~90 nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic infl...

YN380044 SPL-707 2195361-33-0

SPL-707 is an orally active, selectivesignal peptide peptidase-like 2a (SPPL2a)inhibitor with an IC50 of 77nM for hSPPL2a. SPL-707 inhibitsγ-secretase(IC50=6.1μM) and SPP(IC50=3.7μM). SPL-707 has the potenti...

YN330114 Interferon receptor inducer-1 2215120-36-6

Interferon receptor inducer-1 (compound 6) is an interferon(IFN)receptor inducer. Used accordingly in the treatment of a disorder in which the induction of interferon is involved.

YN420129 Rheb inhibitor NR1 2216763-38-9

Rheb inhibitor NR1 is aRhebinhibitor with an IC50 of 2.1 µM in the Rheb-IVK assay. Rheb inhibitor NR1 also is a selectivemTORC1inhibitor. NR1 inhibits the phosphorylation ofT389pS6K1 and increases the phosphorylat...