YN481807 Tiopronin 13C D3 1189695-13-3

Tiopronin 13C D3 is deuterium labeled Tiopronin.

YN481793 Methocarbamol D5 1189699-70-4

Methocarbamol D5 is deuterium labeled Methocarbamol. Methocarbamol is a central muscle relaxant.

YN360809 Triamterene D5 1189922-23-3

Triamterene D5 is deuterium labeled Triamterene, which can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic.

YN360651 IOWH-032 1191252-49-9

IOWH032 is a synthetic CFTR inhibitor with IC50 of 1.01 μM in CHO-CFTR cell based assays. Phase 2.

YN370445 Dorzagliatin 1191995-00-2

Dorzagliatin (HMS5552), a dual-actingglucokinase (GK)activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes.

YN320837 TGR5 Receptor Agonist 1197300-24-5

TGR5 Receptor Agonist (CCDC), a potentTGR5(GPCR19)agonist, shows improved potency in the U2-OS cell assay (pEC50=6.8) and in melanophore cells (pEC50=7.5).

YN373108 Coptisine Sulfate 1198398-71-8

Coptisine Sulfate is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitiveIDOinhibitor with aKivalue of 5.8μM and an IC50 value of 6.3μM.

YN330244 Tofogliflozin (hydrate) 1201913-82-7

Tofogliflozin is a novel sodium-glucose co-transporter 2(SGLT2) inhibitor with IC50 values of 2.9 nM and 8444 nM for hSGLT2 and hSGLT1, respectively.

YN372503 AS1949490 1203680-76-5

AS1949490 is a potent and selectiveSHIP-2 (SH2 domain-containing inositol 5′ phosphatase 2)inhibitor, with an IC50 of 620nM. AS1949490 activated glucose metabolism via up-regulation of GLUT1 gene in L6 myotubes.

YN410074 Edasalonexent 1204317-86-1

Edasalonexent (CAT-1004) is an orally bioavailableNF-κBinhibitor.

YN321299 Fesoterodine L-mandelate 1206695-46-6

Fesoterodine L-m and elate is an orally active, nonsubtype selective, competitivemuscarinic receptor (mAChR)antagonist with pKi values. of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine L-m...

YN1720007 LGD-6972 1207989-09-0

LGD-6972 is a selective and orally activeglucagon receptorantagonist. LGD-6972 has the potential for type 2 diabetes research.

YN360540 Ertugliflozin 1210344-57-2

PF-04971729 (Ertugliflozin) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2).

YN360541 Ertugliflozin L-pyroglutamic... 1210344-83-4

Ertugliflozin (MK-8835, PF-04971729) L-pyroglutamic acid is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2) with IC50 of 0.877 nM for h-SGLT2. Ertugliflozin ha...

YN1720014 (Rac)-Mirabegron D5 1215807-38-7

(Rac)-Mirabegron D5 ((Rac)-YM178 D5) is a deuterium labeled (Rac)-Mirabegron. (Rac)-Mirabegron is the racemate of Mirabegron. Mirabegron is a selectiveβ3-adrenoceptoragonist.

YN280072 GSK4112 1216744-19-2

GSK4112 is a functional Rev-erbα agonist with an EC50 of 0.4 μM. It represses the expression of gluconeogenic genes in liver cells and reduces glucose output in primary hepatocytes.

YN470024 VD2-D3 1217448-46-8

VD2-D3 is a deuterated form of vitamin D.

YN481425 Repaglinide D5 1217709-85-7

Repaglinide D5 (AG-EE 623ZW D5) is deuterium labeled Repaglinide. Repaglinide is aninsulin secretagoguefor the treatment of type-2 diabetes mellitus.

YN370210 Atorvastatin lactone D5 1217749-86-4

Atorvastatin lactone D5 is a deuterated form of Atorvastatin lactone (HY-101873). Atorvastatin lactone is a prodrug form of atorvastatin. Atorvastatin is an orally active3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)reductase ...

YN420059 MK-3903 1219737-12-8

MK-3903 is a potent and selective AMPK activator with an EC50 of 8 nM for α1 β1 γ1 subunit. It activates 10 of the 12 pAMPK complexes with EC50 values in the range of 8-40 nM and maximal activation >50%.