YN320079 Setogepram sodium salt 1254472-97-3

Setogepram sodium salt (PBI-4050 sodium salt) acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84. Setogepram sodium salt decreases renal, liver and pancreatic fibrosis. Setogepram sod...

YN320476 SSTR5 antagonist 2 TFA 1254733-98-6

SSTR5 Antagonist 1 (compound 10) is a highly potent, oral active and selective somatostatin (receptor) subtype 5 (SSTR5)antagonist and has potential to treat type 2 diabetes mellitus (T2DM).

YN481390 SR8278 1254944-66-5

SR8278 is a competitive nuclear heme receptorREV-ERBsynthetic antagonist. SR8278 inhibits the REV-ERBα transcriptional repression activity with an EC50 of 0.47μM. SR8278 is used to regulate the metabolism in organisms...

YN370582 Retagliptin Phosphate 1256756-88-3

Retagliptin Phosphate is pharmaceutical composition ofDPP-4inhibitor for treating type-2 diabetes.

YN320060 BMS-986020 1257213-50-5

BMS-986020 (AM152, AP-3152 free acid) is a potent and selective antagonist of lysophosphatidic acid receptor 1 (LPA1). BMS-986020 inhibits bile acid and phospholipid transporters with IC50 of 4.8 μM, 6.2 μM, and 7.5 μM ...

YN320815 AMG 837 calcium hydrate 1259389-38-2

AMG 837 calcium hydrate is a potent GPR40 agonist(EC50=13nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.

YN420085 O-304 1261289-04-6

O-304 (O-304X) is an orally available pan-activator of AMPK activated protein kinase (AMPK). O-304 (O-304X) exhibits a great potential as a novel drug to treat type 2 diabetes (T2D) and associated cardiovascular compl...

YN370447 Enarodustat 1262132-81-9

Enarodustat (JTZ-951) is a potent and orally active HIF prolyl hydroxylase inhibitor with IC50 of 0.22 μM for PHD2 and EC50 of 5.7 μM for EPO release from Hep3B cells. Enarodustat has the potentia...

YN470023 25-Hydroxy VD2-D6 1262843-46-8

25-Hydroxy VD2-D6 is a labelled metabolite of Vitamin D2.

YN360308 GSK205 1263068-83-2

GSK205 is a potent, selective TRPV4 antagonist with an IC50 of 4.19 μM for inhibitingTRPV4-mediated Ca2+influx.

YN370050 PX20606 trans racemate 1268244-85-4

PX20606 trans racemate (PX-102 trans racemate) is a FXR agonist with EC50s of 32 and 34nM for FXR in FRET and M1H assay, respectively.

YN371203 BioE-1115 1268863-35-9

BioE-1115 is a highly selective and potent dual inhibitor of PAS kinase (PASK) and casein kinase 2α (CK2α) with IC50 of ~4 nM and ~10 μM, respectively.

YN480647 TXNIP-IN-1 1268955-50-5

TXNIP-IN-1 isTXNIP-TRX (thioredoxin-interacting protein- thioredoxin) complexinhibitor extracted from patent US20200085800A1, Compound 1. TXNIP-IN-1 can be used in the research of TXNIP-TRX complex associat...

YN372464 Nicodicosapent 1269181-69-2

Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein(SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP ci...

YN480932 DIPQUO 1269365-82-3

DIPQUO is an activator of the bone markeralkaline phosphatase (ALP), with an EC50 of 6.27μM in C2C12 cells. DIPQUO promotes mouse and human osteoblast differentiation via activation of p38 MAPK-β.

YN372447 Rosuvastatin D3 Sodium 1279031-70-7

Rosuvastatin D3 Sodium is deuterium labeled Rosuvastatin, which is a competitive inhibitor of HMG-CoA reductase with IC50 of 11nM.

YN360231 Dotinurad 1285572-51-1

Dotinurad is a potent and selective urate reabsorption inhibitor. Dotinurad inhibits urate transporter 1 (URAT1) with an IC50 value of 37.2nM. Dotinurad acts as a uricosuric agent.

YN330183 PTUPB 1287761-01-6

PTUPB is a potent and dualsEH and COX-2enzymes inhibitor with IC50 of 0.9nM and 1.26μM, respectively.

YN360233 Licogliflozin 1291094-73-9

Licogliflozin is a sodium glucose cotransporter (SGLT1 and SGLT2) inhibitor.

YN320791 Orexin receptor antagonist 3 1293282-55-9

Orexin receptor antagonist 3 (example 216) is anorexin receptorantagonist, which is extracted from the patent WO2011050198A1.