YN440162 Insulin levels modulator 1019254-94-4

Insulin levels modulator could be used to treat diabetes.

YN321656 Lorglumide sodium salt 1021868-76-7

Lorglumide sodium salt (CR-1409 sodium salt) is a potentcholecystokinin(CCK)receptorantagonist.

YN482847 Ganolactone B 1028449-53-7

Ganolactone B is a lanostane-type triterpene isolated from the fruiting bodies ofG. sinense.

YN480624 LY2452473 1029692-15-6

LY2452473 is an orally bioavailable, selective and rogen receptormodulator (SARM).

YN372299 Trelagliptin succinate 1029877-94-8

Trelagliptin succinate is a dipeptidyl peptidase IV (DPP-4) inhibitor which is used as a new long-acting drug for once-weekly treatment of type 2 diabetes mellitus (DM).

YN372596 Potassium 2-hydroxy-2-methyls... 1030365-02-6

Potassium 2-hydroxy-2-methylsuccinate is an endogenous metabolite.

YN371244 MK-8245 1030612-90-8

MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. Phase 2.

YN372269 ABT-046 1031336-60-3

ABT-046 is a potent, selective, and orally efficacious acyl CoA:diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC50= 8nM).

YN320537 GSK1292263 1032823-75-8

GSK1292263 is a novel GPR119 agonist, showing potential for the treatment of type 2 diabetes. Phase 2.

YN320961 MBX-2982 1037792-44-1

MBX-2982 is a selective, orally-available G protein-coupled receptor 119 (GPR119) agonist.

YN370381 MK-4074 1039758-22-9

MK-4074 is a liver-specific inhibitor ofacetyl-CoA carboxylaseACC1 and ACC2 with IC50 values of approximately 3nM.

YN372353 LP-533401 hydrochloride 1040526-12-2

LP-533401 hydrochloride is atryptophan hydroxylase 1inhibitor that regulates serotonin production in the gut.

YN372383 FGH10019 1046045-61-7

FGH10019 is a novel sterol regulatory element-binding protein (SREBP) inhibitor with IC50 of 1μM.

YN481619 AZD8329 1048668-70-7

AZD8329 is a potent11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1)inhibitor with an IC50 of 9nM for human 11β-HSD1, displays excellent selectivity versus 11β-HSD2, 17β-HSD1 and 17β-HSD3.

YN321276 GPR120 modulator 1 1050506-75-6

GPR120 modulator 1 is aG protein coupled receptor 120 (GPR120)modulator extracted from patent US8394841B2, compound example F1. GPR120 modulator 1 can be used for the research of diseases associated with abnormal or deregulate...

YN321277 GPR120 modulator 2 1050506-87-0

GPR120 modulator 2 is aG protein coupled receptor 120 (GPR120)modulator extracted from patent US8394841B2, compound example F13. GPR120 modulator 2 can be used for the research of diseases associated with abnormal or deregulat...

YN360251 MK6-83 1062271-24-2

MK6-83 is a new c and idate agonist ofTRPML1with an improved efficacy and potency. MK6-83 has the potential for Mucolipidosis type IV study.

YN320417 SNT-207707 1064662-40-3

SNT-207707 is a selective, potent and orally activemelanocortin MC-4receptor antagonist with an IC50 of 8nM (binding) and 5nM (function) on the MC-4 receptor.

YN370592 SCD1 inhibitor-1 1069094-65-0

SCD1 inhibitor-1 is a potent and liver-selectivestearoyl-CoA desaturase-1 (SCD1)inhibitor.

YN320859 TUG-424 1082058-99-8

TUG-424 is a potent and selectivefree fatty acid receptor 1 (FFA1/GPR40)agonist with an EC50 of 32nM. TUG-424 significantly increases glucose-stimulated insulin secretion at 100nM. TUG-424 may serve to explore the role ...