YN481681 Emixustat hydrochloride 1141934-97-5

Emixustat hydrochloride strongly inhibits 11-cis-retinol production with IC50 values of 232 ± 3nM. Emixustat hydrochloride is a novel visual cycle modulator, in healthy volunteers. Oral Emixustat was safe  and  well t...

YN320739 AM-1638 1142214-62-7

AM-1638 is a potent and orally bioavailableGPR40/FFA1full agonist with an EC50 of 0.16μM.

YN483676 Neopuerarin A 1150314-34-3

Neopuerarin A is an isoflavones isolated from the water extraction of the dried roots ofPueraria lobata(Willd.). Neopuerarin A shows significant hepatoprotective effect.

YN483677 Neopuerarin B 1150314-39-8

Neopuerarin B is an isoflavones isolated from the water extraction of the dried roots ofPueraria lobata(Willd.). Neopuerarin B shows significant hepatoprotective effect.

YN360529 Lesinurad sodium 1151516-14-1

Lesinurad (Selexipag, RDEA-594) sodium (Zurampic) is a selective uric acid reabsorption inhibitor (SURI) under investigation for treatment of gout. Lesinurad sodium inhibits the uric acid transporter URAT1 and ...

YN420325 AMPK activator 1 1152423-98-7

AMPK activator 1 is anAMPKactivator extracted from patent WO2013116491A1, compound No.1-75, has an EC50 of <0.1μM.

YN480333 A 1120 1152782-19-8

A 1120 is a high-affinity nonretinoidretinol-binding protein 4 (RBP4)antagonist with aKivalue of 8.3nM. A 1120 disrupts the interaction between RBP4 and its binding partner transthyretin.

YN483866 RETF-4NA 1160928-63-1

RETF-4NA, a chymase-specific substrate, is a sensitive and selective substrate for chymase when free or bound to α2M.

YN372584 BAY-85-8501 1161921-82-9

BAY-85-8501 is a selective, reversible and potent inhibitor ofHuman Neutrophil Elastase (HNE), with an IC50 of 65 pM.

YN372310 AZD7687 1166827-44-6

AZD7687 is a potent, selective, reversible and orally activediacylglycerol acyltransferase 1 (DGAT1)inhibitor with an IC50 of 80nM forhuman DGAT1. AZD7687 can be used for type 2 diabetes mellitus and obesity research.

YN482906 9''-Methyl salvianolate B 1167424-31-8

9''-Methyl salvianolate B is a phenolic compound isolated from RadixSalvia miltiorrhizae.

YN320434 ALB-127158(a) 1173154-32-9

ALB-127158(a) is a potent and selective melanin concentrating hormone 1 (MCH1) receptor antagonist.

YN372266 EMD638683 1181770-72-8

EMD638683 is a highly selective inhibitor of serum- and glucocorticoid-inducible kinase 1 (SGK1) with IC50 of 3 μM. EMD638683 exhibits antihypertensive potency and anti-tumor activity.

YN372268 EMD638683 S-Form 1184940-46-2

EMD638683 S-Form is the S-form of EMD638683. EMD638683 is a highly selectiveSGK1inhibitor with IC50 of 3μM.

YN372267 EMD638683 R-Form 1184940-47-3

EMD638683 R-Form is the R-form of EMD638683. EMD638683 is a highly selectiveSGK1inhibitor with IC50 of 3μM.

YN420071 Metformin D6 hydrochloride 1185166-01-1

Metformin D6 hydrochloride is a deuterium labeled Metformin hydrochloride. Metformin hydrochloride inhibits themitochondrial respiratory chainin the liver, leading to activation ofAMPK, enhancing insulin sensitivity for type 2 diabe...

YN483442 Steviol-​19-​O-​glucoside 1185737-16-9

Steviol-​19-​O-​glucoside is a metabolite of steviol in the steviol glycosides biosynthesis pathway inStevia rebuadiana.

YN371022 DBPR108 1186426-66-3

DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15nM; no inhibition on DDP8 and DPP9. DBPR108 is an IC50=15nM DPP IV inhibitor displays a more than 300...

YN320473 ML-109 1186649-91-1

ML-109 is a potent and full thyroid stimulating hormone receptor (TSHR) agonist, with an EC50of 40nM.

YN321491 Loperamide D6 hydrochloride 1189469-46-2

Loperamide D6 hydrochloride (R-18553 D6 hydrochloride) is a deuterium labeled Loperamide hydrochloride. Loperamide hydrochloride is anopioid receptoragonist for the treatment of diarrhea.