YN420090 EX229 1219739-36-2

EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK.

YN372722 Acarbose sulfate 1221158-13-9

Acarbose (BAY g 5421) sulfate, antihyperglycemic agent, is an orally activealpha-glucosidaseinhibitor (IC50=11nM). Acarbose sulfate can potentiate the hypoglycemic effects of sulfonylureas or insulin .

YN370430 GSK2033 1221277-90-2

GSK2033 is aLXRantagonist with pIC50s of 7  and  7.4 forLXRαorLXRβ, respectively.

YN370868 Evogliptin tartrate 1222102-51-3

Evogliptin tartrate is a potent, orally bioavailable and selectivedipeptidyl peptidase-4 (DPP-4)inhibitor, with antidiabetic activity. Evogliptin tartrate has potential for anti-atherosclerosis therapy that targets arterial inflammat...

YN372369 Omarigliptin 1226781-44-7

Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM). It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and...

YN360784 Nateglinide D5 1227666-13-8

Nateglinide D5 is a deuterium labeled Nateglinide. Nateglinide, a D-phenylalanine derivative, is an orally active and short-acting insulinotropic agent and aDPP IVinhibitor. Nateglinide inhibits ATP-sensitiveK+channels in...

YN320510 PF-04634817 1228111-63-4

PF-0463481 is a potent and orally active dualCCR2/CCR5antagonist with comparable human and rodent CCR2 potency (ratIC50=20.8nM), and displays 10-20 fold less rodent CCR5 potency (ratIC50=470nM). PF-0463481 is saf...

YN300027 Pyrintegrin 1228445-38-2

Pyrintegrin is anβ1-integrinagonist and a 2,4-disubstituted pyrimidine that promotes embryonic stem cells survival. Pyrintegrin enhances cell-extracellular matrix (ECM) adhesion-mediatedintegrinsignaling. Pyrintegrin can be used as...

YN484109 Biotin-TAT (47-57) 1231898-25-1

Biotin-TAT (47-57), a biotin tagged TAT, is a transactivator of transcription. Biotin-TAT (47-57) is one of the most widely used protein transduction domains (PTDs) into different primary cells is ATP- and temperature-dep...

YN420139 Ampkinone 1233082-79-5

Ampkinone is an indirect AMP-activated protein kinase (AMPK) activator.

YN371568 Globalagliatin 1234703-40-2

LY2608204 activates glucokinase (GK) with EC50 of 42 nM. Phase 2.

YN320433 GPR120 Agonist 2 1234844-11-1

GPR120 Agonist 2 is aGPR120agonist extracted from patent US 20110313003 A1, example 209.

YN480672 D5D-IN-326 1236767-85-3

D5D-IN-326 is a selective, orally activedelta-5 desaturase (D5D)inhibitor, with IC50s of 72 and 22nM for rat and human D5D in enzymic and cell-based assays, respectively, has no effect on D6D or D9D activity. D5D-IN...

YN374006 Soluble epoxide hydrolase inh... 1241826-88-9

Soluble epoxide hydrolase inhibitor is an inhibitor ofsoluble epoxide hydrolase, and inhibits human soluble epoxide hydrolase (h-sEH) withpIC50 of 8.4, extracted from patent WO 2010096722 A1, example 57.

YN360630 (3S,5R)-Rosuvastatin 1242184-42-4

(3S,5R)-Rosuvastatin is the (3S,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoAreductase inhibitor with an IC50 of 11nM. Rosuvastatin potently blockshuman ether-a-go-go related gene (hERG)current wit...

YN320838 Glucocorticoid receptor agoni... 1245526-82-2

Glucocorticoid receptor agonist is a potent Glucocorticoid receptor agonist.

YN370412 PF-04937319 1245603-92-2

PF-04937319 is a glucokinase activator (GKA) withEC50value of 154.4  μM, one of the most promising strategies for the treatment of type 2 diabetes mellitus. PF-04937319 is designed to maintain glucose-lowering efficacy while mit...

YN1720010 TT-OAD2 free base 1246826-07-2

TT-OAD2 free base is a non-peptideglucagon-like peptide-1 (GLP-1) receptoragonist with an EC50 of 5nM. TT-OAD2 free base has the potential for diabetes treatment.

YN410089 Curcumin D6 1246833-26-0

Curcumin D6 (Diferuloylmethane D6) is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiprolife...

YN320454 TM38837 1253641-65-4

TM38837 is a peripheral selectivecannabinoid receptor type 1 (CB1)receptor antagonist. TM38837 shows limited penetrance to the brain in order to minimize or prevent CNS adverse reactions, and preserves potential antiobesity effec...