YN371196 PF-05175157 1301214-47-0

PF-05175157 is broad spectrumacetyl-CoA carboxylase(ACC) inhibitor with IC50s of 27.0, 33.0, 23.5 and 50.4nM for ACC1 (human), ACC2 (human), ACC1 (rat), ACC2 (rat), respectively.

YN480429 (±)-CPSI-1306 1309793-47-2

(±)-CPSI-1306 is an orally available antagonist of macrophage migration inhibitory factor(MIF).

YN372485 AA26-9 1312782-34-5

AA26-9 is a potent and broad spectrumserine hydrolaseinhibitor. AA26-9 targets included serine peptidases, lipases, amidases, esterases, and thioesterases. AA26-9 shows inhibitory activity against approximately 1/3 of the 40+ seri...

YN320626 GPR40 Activator 2 1312787-30-6

GPR40 Activator 2 is a potent GPR40 activator from patents WO 2012147516 A1, WO 2012046869A1 and WO 2011078371 A1.

YN321346 Mebeverine D6 Hydrochloride 1329647-20-2

Mebeverine D6 Hydrochloride is the deuterium labeled Mebeverine, which is an antimuscarinic.

YN320614 PF-5190457 1334782-79-4

PF-5190457 (PF-05190457) is a potent and selectiveghrelin receptorinverse agonist with a pKi of 8.36.

YN420313 3α-Hydroxymogrol 1343402-73-2

3α-Hydroxymogrol is a triterpenoid isolated fromSiraitia grosvenoriiSwingle, acts as a potentAMPKactivator, and enhances AMPK phosphorylation.

YN481548 Linerixibat 1345982-69-5

Linerixibat (GSK2330672) is a highly potent, nonabsorbable and orally activeapical sodium-dependent bile acid transporter (ASBT)inhibitor with an IC50 of 42nMhuman ASBT. Linerixibat can be used as lipid-lowering agent. Li...

YN320689 Phenylethanolamine A 1346746-81-3

Phenylethanolamine A acts as aβ-adrenergicagonist. Phenylethanolamine A is a byproduct during the Ractopamine synthesis process.

YN1720011 Bis-propargyl-PEG7 1351373-46-0

Bis-propargyl-PEG7 is aPEG-based PROTAC linkerused in the synthesis of PROTACs. Bis-propargyl-PEG7 can be used to synthesize the polymer linked multimers of guanosine-3', 5'-cyclic monophosphates.

YN371574 3'-Hydroxy Repaglinide D5 1352792-15-4

3'-Hydroxy Repaglinide D5 is the deuterium labeled 3'-Hydroxy Repaglinide. 3'-Hydroxy Repaglinide is a main CYP2C8 metabolite of Repaglinide.

YN360589 Verinurad 1352792-74-5

Verinurad (RDEA3170) is a high-affinity inhibitor of the URAT1 transporter with an IC50 of 25 nM for inhibiting transport activity of human URAT1. It inhibits the related URAT1 homologs OAT4 and OAT1 with approxi...

YN330094 Poseltinib 1353552-97-2

Poseltinib, an orally active, selective and irreversibleBruton’s tyrosine kinase (BTK)inhibitor (IC50=1.95nM), with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX, TEC and TXK, respectively. Poseltinib can co...

YN372523 Aldose reductase-IN-1 1355612-71-3

Aldose reductase-IN-1 is a inhibitor of aldose reductase with IC50 of 28.9 pM.

YN370995 AMG-3969 1361224-53-4

AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor with an IC50 of 4nM.

YN372339 GNE-617 1362154-70-8

GNE-617 is a highly potent inhibitor of NAMPT activity with an IC50 of 5 nM.

YN480330 YK11 1370003-76-1

YK11 is a partial agonist of and rogen receptor, with osteogenic activity.

YN480988 CO23 1370363-74-8

CO23 is a selectivethyroid hormone receptor (TR) αagonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier.

YN1720002 BETP 1371569-69-5

BETP is an agonist ofglucagon-like peptide-1 (GLP-1) receptor, with EC50s of 0.66 and 0.755μM for human and ratGLP-1 receptor, respectively.

YN320086 TUG-891 1374516-07-0

TUG-891 is a potent and selective agonist for the long chain free fatty acid (LCFA) receptor 4 (FFA4/GPR120).