Chemical structure
Cat.No.
Product Name
CAS no.
Target
kira6 is a potent type II IRE1α kinase inhibitor with an IC50 of 0.6 μM. It dose-dependently inhibits IRE1α(WT) kinase activity, XBP1 RNA cleavage, Ins2 RNA cleavage and oligomerization.
YN320150 GPR120-IN-1 1599477-75-4
GPR120-IN-1 is a selectiveGpr120agonist with alogEC50of −7.62.
YN483439 Mogroside II-A 1613527-65-3
Mogroside II-A is a natural product isolated fromSiraitia grosvenorii.
YN320223 TC-G-1008 1621175-65-2
TC-G-1008 (GPR39-C3) is a potent and orally available GPR39 agonist withEC50values of 0.4 and 0.8nM for rat and human receptors respectively.
YN300023 para-Nitroblebbistatin 1621326-32-6
para-Nitroblebbistatin is a non-cytotoxic, photostable, fluorescent and specificMyosin IIinhibitor, usd in the study of the specific role of myosin II in physiological, developmental, and cell biological studies.
KY-226 is a potent, selective, orally active and allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B) with IC50 of 0.28 μM for human PTP1B activity. KY-226 exerts anti-diabetic and anti-obesity effects by ...
VR23 is a potent proteasome inhibitor with IC50 of 1 nM, 50-100 nM, and 3 μM for trypsin-like proteasomes, chymotrypsin-like proteasomes, and caspase-like proteasomes, respectively.
YN440012 GSK3179106 1627856-64-7
GSK3179106 is a potent, selective, and gut-restricted pyridone hinge binder small molecule RET kinase inhibitor with a RET IC50 of 0.3 nM and is efficacious in vivo.
YN372569 PKR-IN-2 1628428-01-2
PKR-IN-2 is a pyruvate kinase isoformPKRactivator extracted from patent WO2014139144A1, compound 160. PKR-IN-2 can be used for the research of PKR function related diseases, including cancer, diabetes, obesity, autoimmune...
YN320217 SSTR5 antagonist 1 1628741-91-2
SSTR5 antagonist 1 is a potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonist with IC50s of 9.6 and 57nM for hSSTR5 and mSSTR5, respectively. (Compound 25a)
YN481562 Ibiglustat (L-Malic acid) 1629063-78-0
Ibiglustat L-Malic acid (Venglustat L-Malic acid), a potential therapy for PD Parkinson’s disease, SRT in Fabry’s and Gaucher’s, is a selective, allosteric inhibitor ofglucosylceramide synthase (GCS)with ability to cro...
YN370205 SBC-110736 1629166-02-4
SBC-110736 is an inhibitor of proprotein convertase subtilisin kexin type 9 (PCSK9) that lowers cholesterol levels in mice.
YN290472 Saroglitazar Magnesium 1639792-20-3
Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity withEC50values of 0.65 pM and 3nM in HepG2 cells, respectively.
YN470026 Alfacalcidol-D6 1641940-94-4
Alfacalcidol-D6, a deuterated Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3), is a non-selective VDR activator medication. Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitam...
SAFit1 is a FK506 binding protein 51 (FKBP51)-specific inhibitor with a Ki of 4±0.3nM.
LNP023 is an orally bioavailable, highly potent and highly selectivefactor Binhibitor. LNP023 shows direct, reversible, and high-affinity binding to human factor B with aKDof 7.9nM. LNP023 inhibits factor B with an IC50...
JZP-430 is a potent, highly selective, irreversible inhibitor ofα/β-hydrolase domain 6 (ABHD6)with an IC50 of 44nM, exhibits ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL).
EML425 is a potent and selective CREB binding protein (CBP)/p300inhibitor with IC50s of 2.9 and 1.1μM, respectively.
YN440173 AZ-Dyrk1B-33 1679330-37-0
AZ-Dyrk1B-33 is a potent and selectiveDyrk1B kinaseinhibitor, with an IC50 of 7nM.
YN481279 NHS-PEG1-SS-PEG1-N... 1688598-83-5
NHS-PEG1-SS-PEG1-NHS is a reversiblelinkerfor biomacromolecule link with active small molecule. NHS-PEG1-SS-PEG1-NHS can be used in proteins liposomes or nanoparticles.
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