YN480795 CD38 inhibitor 1 1700637-55-3

CD38 inhibitor 1 (compound 78c) is a potentCD38inhibitor with IC50s of 7.3nM and 1.9nM for hCD38 and mouse CD38.

YN320512 Exicorilant 1781244-77-6

Exicorilant (CORT 125281) is a selective and oral activeglucocorticoid receptor (GR)antagonist, with aKivalue of 7nM. Exicorilant (CORT 125281) has potential to overcome adiposity, glucose intolerance and dyslipidaemia.

YN372588 HIF-2α-IN-1 1799948-06-3

HIF-2α-IN-1 is a HIF-2α inhibitor has an IC50 of less than 500nM in HIF-2α scintillation proximity assay.

YN410004 KI696 isomer 1799974-69-8

KI696 isomer is the less active isomer of KI696 (HY-101140). KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction.

YN410003 KI696 1799974-70-1

KI696 is a high affinity probe that disrupts the Keap1/NRF2 interaction. KI696 is a potent and selective inhibitor of theKEAP1/NRF2interaction.

YN370208 MGAT2-IN-1 1800025-30-2

MGAT2-IN-1 is an orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) with IC50 of 7.8 and 2.4nM for human and mouse MGAT2, respectively.

YN371181 KL1333 1800405-30-4

KL1333, a derivative of β-lapachone, is an orally availableNAD+modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidati...

YN480704 Biliatresone 1801433-90-8

Biliatresone is a natural toxin isolated fromDysphania glomulifera and D. littoralis. Biliatresone, a 1,2-diaryl-2-propenone class of isoflavonoid, produces extrahepatic biliary atresia in a zebrafish model.

YN440443 GIP (3-42), human 1802086-25-4

GIP (3-42), human acts as a glucose-dependent insulinotropic polypeptide (GIP) receptor antagonist, moderating the insulin secreting and metabolic actions of GIP in vivo.

YN483504 Celosin I 1807732-38-2

Celosin I, an oleanane-type triterpenoid saponin isolated from the seeds ofCelosia argenteaL, could be used as chemical markers for the quality control ofC. argenteaseeds. Celosin I exhibits significant hepatoprotective effect on car...

YN370413 PF-06471553 1808094-07-6

PF-06471553 is a potent, selective and orally availablemonoacylglycerol acyltransferase 3 (MGAT3)inhibitor, with an IC50 of 92nM.

YN320662 EHP-101 1818428-24-8

EHP-101 (VCE-004.8) is an orally active, specificPPARγ and CB2receptor dual agonist. EHP-101 inhibitsprolyl-hydroxylases (PHDs) and activates theHIFpathway. EHP-101, a semi-synthetic multitarget cannabinoquinoid, h...

YN480680 DO34 1848233-58-8

DO34 is a highly potent, selective and centrally activediacylglycerol lipase (DAGL)inhibitor, with an IC50 of 6nM for DAGLα conversion of SAG to 2-AG, and an IC50 for DAGLβ.

YN420244 ZLN024 hydrochloride 1883548-91-1

ZLN024 hydrochloride is anAMPKallosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µ...

YN480545 TES-991 1883602-20-7

TES-991 is a potent and selective human α‑Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase(ACMSD)inhibitor, with an IC50 of 3nM.

YN480451 TES-1025 1883602-21-8

TES-1025 is a potent and selective human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitor with an IC50 of 13nM.

YN290078 Pparδ agonist 1 1902161-12-9

Pparδ agonist 1 is aPPAR-δagonist, with an EC50 of 5.06nM, used in the research of PPAR-delta related diseases, such as mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic disea...

YN483192 Caesappanin C 1913319-59-1

Caesappanin C, a biphenyl dimer from the ethanolic extract of the heartwood of IndonesianCaesalpinia sappanL., shows strong proliferation stimulating activity against the primary osteoblastic cells in vitro. Caesappanin C has the pot...

YN370054 PTP1B-IN-2 1919853-46-5

PTP1B-IN-2 (MDK3465) is a potent and selective protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 50 nM. PTP1B-IN-2 enhances insulin-mediated insulin receptor β (IRβ) phosphorylation and insulin...

YN370847 LKY-047 1954681-29-8

LKY-047, a Decursin derivative, is a potent and selective reversible competitivecytochrome P45022J2 (CYP2J2)inhibitor with an IC50 of 1.7μM. LKY-047 is inactive against other human P450s, such as CYPs 1A2, 2A6, 2B6...