YN372240 Gemigliptin tartrate 1374639-74-3

Gemigliptin tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC50 of 10.3nM for human recombinant DPP-4. Gemigliptin tartrate exhibits potent an...

YN371062 FASN-IN-4 1375105-96-6

FASN-IN-4 is a potent inhibitor of fatty acid synthase (FASN) extracted from patent WO 2012064642 A1, compound 29; has an IC50 of 10nM.

YN372524 KML29 1380424-42-9

KML29 is an extremely selective, orally active and irreversibleMAGLinhibitor, with IC50 values of 15nM, 43nM and 5.9nM for mouse, rat and human MAGL, respectively. KML29 exhibits minimal cross-reactivity toward othe...

YN320061 BMS-986020 sodium 1380650-53-2

BMS-986020 sodium is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist. BMS-986020 sodium inhibits bile acid and phospholipid transporters with IC50s of 4.8 µM, 6.2 µM, and 7.5 µM for BSEP, MRP4,...

YN480682 HJC0197 1383539-73-8

HJC0197 is a potentEpac1(exchange protein directly activated by cAMP 1) and Epac2(IC50=5.9μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GD...

YN320779 Loperamide phenyl 1391052-94-0

Loperamide phenyl is an impurity of Loperamide (HY-B0418A). Loperamide is anopioid receptoragonist.

YN480979 GLPG0974 1391076-61-1

GLPG0974 is afree fatty acid receptor-2 (FFA2/GPR43)antagonist with an IC50 of 9nM.

YN321194 JD-5037 1392116-14-1

JD-5037 is a peripherally restricted (PR) cannabinoid-1 receptor blocker with an IC50 value of 2 nM for CB1 receptor and > 1000 nM for CB2 receptor.

YN1720017 PF-06291874 1393124-08-7

PF-06291874 is a highly potent, non-peptide and orally activeglucagon receptorantagonist. PF-06291874 is under the study for type 2 diabetes mellitus (T2DM).

YN420075 MK8722 1394371-71-1

MK8722 is a potent and systemicpan-AMPKactivator.

YN370906 APX-115 1395946-75-4

APX-115 (Ewha-18278) is a potent, orally active panNADPH oxidase (Nox)inhibitor with Kivalues of 1.08μM, 0.57μM, and 0.63μM forNox1,Nox2 and Nox4, respectively. APX-115 effectively prevents kidney injury.

YN480868 SJA710-6 1397255-09-2

SJA710-6 is a small molecule able to selectively differentiate MSCs toward hepatocyte-like cells.

YN481561 Ibiglustat 1401090-53-6

Ibiglustat (Venglustat), a potential therapy for PD Parkinson’s disease, SRT in Fabry’s and Gaucher’s, is a selective, allosteric inhibitor ofglucosylceramide synthase (GCS)with ability to cross the blood-brain barrier .

YN321016 TUG-770 1402601-82-4

TUG-770 is a potent, selective and orally activeGPR40/FFA1agonist with an EC50 of 6nM forhuman FFA1. TUG-770 shows a high selectivity forFFA1over FFA2, FFA3, FFA4, PPARγ, other receptors, transporters, ...

YN370893 KT203 1402612-64-9

KT203 is a potent and selective inhibitor ofα/β-hydrolase domain containing 6 (ABHD6), with an IC50 of 0.31nM in Neuro2A cells.

YN320409 TC-G 1005 1415407-60-1

TC-G 1005 is a potent, selective and orally active agonist of theBA receptor Takeda G protein-coupled receptor 5 (TGR5), with EC50s of 0.72 and 6.2nM for hTGR5 and mTGR5, respectively. TC-G 1005 can reduce glucos...

YN371247 MK-8245 Trifluoroacetate 1415559-41-9

MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1nM for human SCD1 and 3nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy.

YN372502 CPDA 1415834-63-7

CPDA is a novel potent SH2 domain-containing inositol phosphatase 2 (SHIP2) inhibitor.

YN370163 SR9238 1416153-62-2

SR9238 is a syntheticliver X receptor (LXR)inverse agonist with IC50s of 214nM and 43nM forLXRα and LXRβ, respectively.

YN481220 (3R,5R)-Rosuvastatin Lacto... 1422954-11-7

(3R,5R)-Rosuvastatin Lactone is an isomer of Rosuvastatin Lactone.