YN321248 LY2922470 1423018-12-5

LY2922470 is a potent, selective and orally available agonist of theG protein-coupled receptor 40 (GPR40), with EC50s of 7nM, 1nM and 3nM for human GPR40, mouse GPR40 and rat GPR40, respectively. LY2922470 reduce...

YN481216 Ezetimibe phenoxy glucuronide... 1426174-41-5

Ezetimibe phenoxy glucuronide-D4 (Ezetimibe glucuronide-D4) is the deuterium labeled Ezetimibe phenoxy glucuronide. Ezetimibe phenoxy glucuronide is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity. Ezetimibe ...

YN372413 Firsocostat 1434635-54-7

Firsocostat is a reversible inhibitor of acetyl CoA carboxylase (ACC) with IC50s of 2.1 nM,6.1 nM for hACC1 and hACC2,respectively.

YN370849 GSK2945 1438071-12-5

GSK2945 is a class of tertiary amine, and is a highly specificRev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α)antagonist with EC50s of 21.5μM and 20.8μM, respectively. GSK2945 enhancescholesterol 7α...

YN330016 2',3'-cGAMP 1441190-66-4

2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer ofinterferon-β (IFNβ). 2',3'-cGAMP is produced in mammali...

YN370021 AM-2394 1442684-77-6

AM-2394 is a structurally distinctglucokinaseactivator (GKA). AM-2394 activates glucokinase (GK) with an EC50 of 60nM.

YN372513 Ivosidenib 1448347-49-6

Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity.

YN371000 DGAT1-IN-1 1449779-49-0

DGAT1-IN-1 is a potent DGAT1 inhibitor with IC50 of < 10nM(cell lysate from Hep3B cells overexpressing human DGAT1).

YN1720029 GLP-1(7-37) acetate 1450806-98-0

GLP-1(7-37) acetate is an intestinal insulinotropic hormone that augments glucose induced insulin secretion.

YN480728 TP-004 1454299-21-8

TP-004 is a potent and reversible inhibitor ofmethionine aminopeptidase 2 (MetAP2), with an IC50 of 6nM.

YN420044 PF-06409577 1467057-23-3

PF-06409577 is orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 ...

YN370414 PF-06424439 methanesulfonate 1469284-79-4

PF-06424439 methanesulfonate is an oral, potent and selective imidazopyridinediacylglycerol acyltransferase 2 (DGAT2)inhibitor with an IC50 of 14nM. PF-06424439 methanesulfonate is slowly reversible, time-dependent inhibitor, w...

YN372355 Atglistatin 1469924-27-3

Atglistatin is a highly potent, and selective inhibitor of adipose triglyceride lipase (ATGL) with IC50 of 0.7 μM, high selectivity over other key metabolic lipases.

YN370924 DPM-1001 1471172-27-6

DPM-1001 is a potent, specific, orally bioavailable and non-competitive inhibitor ofprotein-tyrosine phosphatase (PTP1B)with an IC50 of 100nM, an an analog of the specific PTP1B inhibitor trodusquemine (MSI-1436; IC50=6...

YN1720016 Adomeglivant 1488363-78-5

Adomeglivant is a potent and selective antagonist of glucagon receptor that is used as a chronic treatment for type 2 diabetes.

YN321254 Setmelanotide acetate 1504602-49-6

Setmelanotide acetate (RM-493 acetate) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27nM and 0.28nM for human and rat MC4R, respectively.

YN371344 O-Desisobutyl-O-n-propyl F... 1530308-87-2

O-Desisobutyl-O-n-propyl Febuxostat, extracted from the patent CN 103467412, is anxanthine oxidaseinhibitor.

YN250811 BRD3308 1550053-02-5

BRD3308 is a potant and highly selective inhibitor of HDAC3 with IC50 of 54 nM, 1.26 μM and 1.34 μM for HDAC3, HDAC1 and HDAC2, respectively. BRD3308 activates HIV-1 transcription. BRD3308 suppresse...

YN370557 TP0463518 1558021-37-6

TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with Ki of 5.3 nM for human PHD2. TP0463518 inhibits human PHD1, human PHD3 and monkey PHD2 with IC50 of 18 nM, 63 nM and 22...

YN440151 PRN1008 1575596-29-0

PRN1008 is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase(BTK), with an IC50 of 1.3nM.