YN370335 Arimoclomol citrate 368860-21-3

Arimoclomol citrate (BRX-220 citrate) is a co-inducer of heat shock proteins (HSP). Arimoclomol citrate protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded as...

YN484239 KAT681 373641-87-3

KAT681 is a liver-selective thyromimetic.

YN310072 CAY10602 374922-43-7

CAY10602 is aSIRT1activator. CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells.

YN350104 BRD7389 376382-11-5

BRD7389 is a specificRSKfamily kinase inhibitor with IC50s of 1.5μM, 2.4μM, and 1.2μM forRSK1,RSK2, and RSK3, respectively. BRD7389 is a small-molecule inducer of insulin expression in pancreatic α-cells.

YN481616 BVT-14225 376638-65-2

BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 52nM.

YN320353 SB-649868 380899-24-1

SB-649868 is a potent and selective orally activeorexin(OX)1 and OX2receptor antagonist (pKi=9.4 and 9.5 at the OX1 and OX2receptor, respectively).

YN373322 Oxyresveratrol 2-O-β-D-glu... 392274-22-5

Oxyresveratrol 2-O-β-D-glucopyranoside is a phenolic compound isolated fromMorus nigraroot and is an effectivetyrosinaseinhibitor with an IC50 of 29.75μM.

YN372274 Tiplaxtinin 393105-53-8

Tiplaxtinin(PAI-039) is an orally efficacious and selective plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 2.7 μM.

YN480803 AA147 393121-74-9

AA147, a small moleculeendoplasmic reticulum (ER) proteostasisregulator, selectively activatesATF6arm of the unfolded protein response (UPR) extracted from patent WO2017117430A1, compound 147*.

YN370821 M77976 394237-61-7

M77976 is a specific ATP-competitive inhibitor ofPDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC50 of 648μM. M77976 is potential for the research of obesity and diabetes.

YN480640 MitoBloCK-10 394694-98-5

MitoBloCK-10 (MB-10) is the first small molecule modulator to attenuateprotein-associated motor (PAM) complexactivity. MitoBloCK-10 (MB-10) inhibitsTim44(C-terminal domain) binding to the precursor and to Hsp70.

YN320032 SB-568849 395679-53-5

SB-568849 is amelanin-concentrating hormone receptor 1(MCH R1) antagonist with a pKi of 7.7.

YN484162 Dentonin 400090-20-2

Dentonin (AC-100) is a synthetic fragment derived from MEPE. Dentonin enhances osteogenesis by promoting osteoprogenitor adhesion and facilitates immature adherent cells survival. Dentonin has no significant effect to mature ost...

YN1720005 Bis-propargyl-PEG6 400775-35-1

Bis-propargyl-PEG6 is aPEG-based PROTAC linkerused in the synthesis of PROTACs. Bis-propargyl-PEG6 can be used to synthesize the polymer linked multimers of guanosine-3', 5'-cyclic monophosphates.

YN371616 1-Cyclohexyl-3-dodecyl urea 402939-18-8

1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selectivesoluble epoxide hydrolase (sEH)inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxy...

YN481330 2,2,14,14-Tetramethyl-8-oxope... 413624-71-2

2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid is a ketone compound extracted from patent WO2002030860A2, compound example II-9. 2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid can be used for the research of cardiovascular dise...

YN321095 Grapiprant 415903-37-6

Grapiprant (CJ-023423) is a selectiveEP4 receptorantagonist whose physiological lig and is prostagl and in E2(PGE2). Grapiprant displaces [3H]-PGE2(1nM) binding to dog recombinantEP4 receptor with IC50 value of 35nM an...

YN480793 G6PD activator AG1 421581-52-4

G6PD activator AG1 is a glucose-6-phosphate dehydrogenase (G6PD) activator with an EC50 of 3 µΜ, extracted from patent WO2019023264A1, compound AG1.

YN290480 LY518674 425671-29-0

LY518674 is a potent, selective PPARα antagonist, with an EC50 of 42nM for human PPARα. LY518674 reduces triglycerides in and increased HDL-C and is used for the treatment of atherosclerosis .

YN481205 Desfluoro-atorvastatin 433289-84-0

Desfluoro-atorvastatin is an impurity of Atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids.