YN481469 Elobixibat 439087-18-0

Elobixibat is a potentileal bile acid transporter (IBAT)inhibitor with IC50 values of 0.53 ± 0.17nM, 0.13 ± 0.03nM, and 5.8 ± 1.6nM for human IBAT, mouse IBAT, and canine IBAT.

YN480366 Pro-xylane 439685-79-7

Pro-xylane (Hydroxypropyl tetrahydropyrantriol) is a biologically active C-glycoside in aqueous media, acts as an activator of glycosaminoglycans (GAGs) biosynthesis. Pro-xylane is the first example of 'Green' chemical used in cosme...

YN360504 Remogliflozin etabonate 442201-24-3

Remogliflozin etabonate (GSK189075) is an orally active, selective and low-affinity inhibitor of sodium glucose cotransporter (SGLT2) with Ki of 1950 nM, 2140 nM, 43100 nM, 8570 nM for hSGLT2, rSGLT2, hSGLT1, rSGL...

YN320215 SB756050 447410-57-3

SB-756050 is a selective TGR5 agonist (EC50 = 1.3 μM for the human receptor).

YN370415 PA452 457657-34-0

PA452,retinoic X receptor(RXR) specific antagonist, inhibits the effect of Retinoic acid (RA) on Th1/Th2 development.

YN450066 I3MT-3 459420-09-8

I3MT-3 (HMPSNE) is a potent, selective, and cell-membrane permeable inhibitor of3-Mercaptopyruvate sulfurtransferase (3MST)(IC50=2.7μM) and is inactive for other H2S/sulfane sulfur-producing enzymes. I3MT-3 target...

YN360148 Dapagliflozin 461432-26-8

Dapagliflozin is a potent and selective hSGLT2 inhibitor with EC50 of 1.1 nM, exhibiting 1200-fold selectivity over hSGLT1. Phase 4.

YN1720040 Bay 55-9837 463930-25-8

Bay 55-9837 is a potent and highly selective agonist ofVPAC2, with aKdof 0.65nM. Bay 55-9837 may be a useful therapy for the research of type 2 diabetes.

YN320942 SSR240612 464930-42-5

SSR240612 is a potent, and orally active specific non-peptidebradykinin B1 receptorantagonist, with Kis of 0.48nM and 0.73nM for B1 kinin receptors of human fibroblast MRC5 and HEK cells expressing human B1 receptors, 4...

YN484183 Pyrrole-derivative1 474006-30-9

Pyrrole-derivative1 is extracted from patent WO/2002/085851A1, example 2, developed for the treatment of diabetic disease.

YN290311 Aleglitazar 475479-34-6

Aleglitazar (R1439;RO0728804) is a potent dualPPARα/γagonist, with IC50s of 38nM and 19nM for human PPARa and PPARγ, respectively. Aleglitazar can be used for the research of type II diabetes.

YN484186 Dirlotapide 481658-94-0

Dirlotapide (CP742033) is a gut-selective inhibitor of microsomal triglyceride transfer protein (MTP) that reliably produces weight loss in obese dogs.

YN371778 Sitagliptin 486460-32-6

Sitagliptin is an oral and highly selective DPP-4 inhibitor with an IC50 of 18 nM. It is used for the treatment of type 2 diabetes.

YN420050 AR-A014418 487021-52-3

AR-A014418 is an ATP-competitive, and selective GSK3β inhibitor with IC50 and Ki of 104 nM and 38 nM in cell-free assays, without significant inhibition on 26 other kinases tested.

YN1720001 GLP-1R Antagonist 1 488097-06-9

GLP-1R Antagonist 1 (compound 5d) is an orally active, CNS penetrant and non-competitive antagonist ofglucagon-like peptide 1 receptor (GLP-1R), with an IC50 of 650nM.

YN481407 Eliglustat 491833-29-5

Eliglustat (Tartrate) inhibits glucosylceramide synthase(GCS) (IC50=20 nM in intact MDCK cells), thus reducing the load of glucosylceramide influx into the lysosome.

YN480892 Genz-123346 free base 491833-30-8

Genz-123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1, the first step in the biosynthesis of gangliosides and other glycosphingolipids.

YN480459 TR antagonist 1 500794-88-7

TR antagonist 1 is a high-affinitythyroid hormone receptor (TR)antagonist with IC50s of 36 and 22nM for TRα and TRβ, respectively.

YN372826 (3S,5S)-Atorvastatin 501121-34-2

(3S,5S)-Atorvastatin is a inactive enantiomer of Atorvastatin. (3S,5S)-Atorvastatin can activatepregnane X receptor (PXR). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decreas...

YN481167 N-(3-Oxotetradecanoyl)-DL-... 503610-29-5

N-(3-Oxotetradecanoyl)-DL-homoserine lactone, a member of N-Acyl homoserine lactone (AHL) from gram-negative bacteria, is a quorum sensing (QS) signaling molecule.