YN483206 Graveobioside A 506410-53-3

Graveobioside A is an anthoxanthin glycoside.

YN250101 Ac-CoA Synthase Inhibitor... 508186-14-9

ACSS2 inhibitor is the most potent and specific inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2).

YN320425 GW-803430 515141-51-2

GW-803430 (GW-3430) is a potent and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist with apIC50 of 9.3. GW-803430 is orally active in an animal model of obesity.

YN480816 Malic enzyme inhibitor ME1 522649-59-8

Malic enzyme inhibitor ME1 (ME1; compound 1) is a potent inhibitor ofMalic enzyme (ME1)with an IC50 of 0.15μM.

YN290546 PPAR agonist 1 539813-69-9

PPAR agonist 1 is an agonist ofPPAR α and PPAR γ, used for reducing blood glucose, lipid levels, lowering cholesterol and reducing body weight.

YN320305 Palosuran 540769-28-6

Palosuran (ACT-058362) is a potent, selective, and orally active antagonist ofurotensin II receptor, with an IC50 of 3.6nM for CHO cell membranes expressing human recombinant receptors. Palosuran can improves pancreatic and ...

YN483460 2-O-β-D-Glucopyranosyl-L-... 562043-82-7

2-O-β-D-Glucopyranosyl-L-ascorbic acid (AA-2βG), isolated fromLycium Fruit, is a stable vitamin C analog with anti-tumor activity.

YN372237 Topiroxostat 577778-58-6

Topiroxostat is a xanthine oxidoreductase (XOR) inhibitor and used for treatment of gout and hyperuricemia.

YN372275 CP-640186 hydrochloride 591778-70-0

CP-640186 hydrochloride is a potent and cell-permeableAcetyl-CoA carboxylase (ACC)inhibitor with IC50s of 53nM and 61nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.

YN484034 26Rfa, Hypothalamic Peptide... 600171-68-4

26Rfa, Hypothalamic Peptide, human is a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. 26RFa is an orexigenic neuropeptide identified as the endogenous lig and of the orphan G protein-coupled rece...

YN484111 Orphan GPCR SP9155 agon... 600171-70-8

Orphan GPCR SP9155 agonist P550 (mouse, rat) (26RFa (mouse, rat)), a member of the RFamide peptide family with orexigenic effect, is the cognate lig and of the mouse orphan receptor GPR103, also designated SP9155 or AQ27...

YN370046 Odanacatib 603139-19-1

Odanacatib (MK 0822) is a potent, selective, and neutral inhibitor of cathepsin K (human/rabbit) with IC50 of 0.2 nM/1 nM, and demonstrated high selectivity versus off-target cathepsin B, L, S. Phase 3.

YN420190 GSK-3 inhibitor 1 603272-51-1

GSK-3 inhibitor 1 is an inhibitor ofGSK-3.

YN370348 PTP1B-IN-1 612530-44-6

PTP1B-IN-1 is a potent protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 of 1.6 mM; 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for derivatives synthesis.

YN420040 AKT inhibitor VIII 612847-09-3

Akti-1/2 is a highly selective Akt1/Akt2 inhibitor with IC50 of 58 nM/210 nM, respectively, about 36-fold selectivity for Akt1 over Akt3.

YN372647 Turofexorate isopropyl 629664-81-9

Turofexorate Isopropyl (XL335) is a potent, selective FXR agonist with EC50 of 4 nM, highly selective versus other nuclear receptors, such as LXR, PPAR, ER and etc. Phase 1.

YN440159 AGL-2263 638213-98-6

AGL-2263 is aninsulin receptor and insulin-like growth factor (IGF) receptorinhibitor.

YN480223 BAY 59-9435 654059-21-9

BAY 59-9435 is a potent and selective inhibitor of Hormone Sensitive Lipase (HSL), with an IC50 of 0.023μM.

YN371781 Sitagliptin phosphate monohyd... 654671-77-9

Sitagliptin phosphate monohydrate is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.

YN371780 Sitagliptin phosphate 654671-78-0

Sitagliptin phosphate (MK-0431 phosphate) is a potent inhibitor ofDPP4with an IC50 of 19nM in Caco-2 cell extracts.