YN360333 KGA-2727 666842-36-0

KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki ...

YN360646 Mizagliflozin 666843-10-3

Mizagliflozin (DSP-3235 free base) is a potent, orally active and selectiveSGLT1inhibitor, with a Ki of 27nM for human SGLT1. Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiab...

YN370249 Linagliptin 668270-12-0

Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM and exhibits a 10,000-fold higher selectivity for DPP-4 than for other dipeptidyl peptidases such as DPP-2, DPP-8, and DPP-9.

YN420280 1-Azakenpaullone 676596-65-9

1-Azakenpaullone is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.

YN370170 HTS01037 682741-29-3

HTS01037 is an inhibitor offatty acidbinding; and a competitive antagonist ofprotein-proteininteractions mediated by AFABP/aP2 with a Ki of 0.67μM.

YN320382 Otenabant 686344-29-6

Otenabant is a potent and selectivecannabinoid receptor CB1antagonist with Kiof 0.7nM, exhibits 10,000-fold greater selectivity against human CB2 receptor.

YN371618 CM10 692269-09-3

CM10 is a potent and selective inhibitor of aldehyde dehydrogenase 1A family (ALDH1A) with IC50 of 1700 nM, 740 nM and 640 nM for ALDH1A1, ALDH1A2 and ALDH1A3, respectively. CM10 exhibits anti-cancer act...

YN372606 T863 701232-20-4

T863 (DGAT-3) is a potent, selective and orally active inhibitor of Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) tht acts on the acyl-CoA binding site of DGAT1 and inhibits DGAT1-mediated triacylglycerol fo...

YN320005 Taranabant 701977-09-5

Taranabant is a highly potent and selectivecannabinoid 1(CB1) receptor inverse agonist that inhibits the binding and functional activity of various agonists, with a bindingKiof 0.13nM for the human CB1R in vitro.

YN480579 MLS0315771 727664-91-7

MLS0315771 is a potent and biologically active competitive phosphomannose isomerase(MPI)inhibitor, with anIC50~1μM and a Ki of 1.4μM.

YN321005 AR 231453 733750-99-7

AR 231453 is a potent, specific and orally availableGPR119agonist. AR 231453 can stimulate β-cell replication and improve islet graft function s.

YN370979 Bempedoic acid 738606-46-7

ETC-1002,also known as Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies.E...

YN372238 Anagliptin 739366-20-2

Anagliptin is an orally active and highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor and exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation.

YN410059 JSH-23 749886-87-1

JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM in RAW 264.7 cell line.

YN372231 Teneligliptin 760937-92-6

Teneligliptin (MP-513) is a potent, orally available, competitive, and long-lastingDPP-4inhibitor. Teneligliptin competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximat...

YN360503 Ipragliflozin 761423-87-4

Ipragliflozin (ASP1941) is a highly selective sodium-glucose cotransporter 2 (SGLT2) inhibitor with an IC50 value of 7.4 nM for hSGLT2 and a 254-fold selectivity versus SGLT1.

YN360332 ORM-10962 763926-98-3

ORM-10962 is a potent, highly selectivesodium-calcium exchanger (NCX)inhibitor, with IC50 values of 67 and 55nM for the reverse and forward mode inhibition, respectively.

YN380212 Acotiamide monohydrochloride ... 773092-05-0

Acotiamide Hydrochloride is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. It is a new orally active selective acetylcholinesterase inhibitor.

YN330292 Imeglimin hydrochloride 775351-61-6

Imeglimin (EMD 387008, IMEG, PXL 008, RVT-1501) Hydrochloride is a new class of oral glucose-lowering agents. Imeglimin normalizes glucose tolerance and insulin sensitivity by preserving mitochondrial function from oxidative...

YN480804 SBI-477 781628-99-7

SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factorMondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domai...