YN483405 4-Hydroxyisoleucine 781658-23-9

4-Hydroxyisoleucine has beneficial effects on low-grade inflammation, it can reverse the insulin resistance by the activation of AMPK and suppression of SOCS-3 coimmunoprecipitation with both the IR-β subunit as well as IRS- ...

YN372469 SA 47 792236-07-8

SA 47 is a selective and potent inhibitor offatty acid amide hydrolase (FAAH) and carbamate.

YN360006 JNJ-17203212 821768-06-3

JNJ-17203212 is a novel and selective TRPV1 antagonist, with IC50 of 65nM and 102nM for human TRPV1 and rat TRPV1.

YN370597 Asp-AMS 828288-98-8

Asp-AMS, an analogue of aspartyl-adenylate, is anaspartyl-tRNA synthetaseinhibitor and also a strong competitive inhibitor of themitochondrial enzyme.

YN270401 Etomoxir sodium salt 828934-41-4

Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase-1 (CPT-1) on the outer face of the inner mitochondrial membrane.

YN360320 AC1903 831234-13-0

AC1903 (compound 2) is a specific and selective TRPC5 (transient receptor potential canonical channel 5) inhibitor with IC50 of 4.06 μM.

YN321006 APD668 832714-46-2

APD668 is a potent GPR119 agonist with EC50s of 2.7 and 33 nM for human and rat forms, respectively.

YN370011 GLX351322 835598-94-2

GLX351322 is a NADPH oxidase 4 (NOX4) inhibitor. GLX351322 inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 μM.

YN290317 Indeglitazar 835619-41-5

Indeglitazar (PPM 204) is an orally availablePPARpan-agonist for all three PPARα, PPARδ and PPARγ.

YN280005 AS1842856 836620-48-5

AS1842856 is a cell-permeable inhibitor that blocks the transcription activity of Foxo1 with IC50 of 33 nM. It could directly bind to the active Foxo1, but not the Ser256-phosphorylated form.

YN320930 Ulimorelin 842131-33-3

Ulimorelin (TZP-101) is aghrelin receptor (GRLN)agonist with an EC50 of 29nM and a Ki of 16nM. Ulimorelin is a prokinetic agent and causes vasorelaxation through competitive antagonist action atα1-adrenoceptors. Ulimorel...

YN360150 Canagliflozin 842133-18-0

Canagliflozin is a highly potent and selective SGLT2 inhibitor for hSGLT2 with IC50 of 2.2 nM in a cell-free assay, exhibits 413-fold selectivity over hSGLT1.

YN481380 Sevelamer carbonate 845273-93-0

Sevelamer carbonate is an orally active and non-calcium-basedphosphate binding agent and used for the hyperphosphatemia of chronic kidney disease (CKD)research. Sevelamer carbonate effectively lowers serum phosphorus levels hile ha...

YN330003 Mitoquinone mesylate 845959-50-4

Mitoquinone mesylate (MitoQ mesylate, MitoQ10, Mitoubiquinone) is a TPP-based, mitochondria-targeted antioxidant that blocks H_{2O2-induced intracellular ROS responses and protects against oxidative damage.}

YN360450 Encequidar 849675-66-7

Encequidar (HM30181; HM30181A) is a potent and selective inhibitor ofP-glycoprotein.

YN372705 Alogliptin Benzoate 850649-62-6

Alogliptin is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.

YN372326 GKA50 851884-87-2

GKA50 is a potentglucokinaseactivator (EC50=33nM at 5 mM glucose). GKA50 stimulates insulin release from mouse islets of Langerhans and MIN6 cells. GKA50 shows significant glucose lowering in high fat fed female rats.

YN483848 HAEGT 852155-81-8

HAEGT is the first N-terminal 1-5 residues of glucagon like peptide-1 (GLP-1) peptide. HAEGT can acts as competitive substrate for probing prime substrate binding sites of human dipeptidyl peptidase-IV.

YN370251 Dutogliptin 852329-66-9

Dutogliptin (PHX-1149 free base) is an orally available, potent, and selectivedipeptidyl peptidase-4(DPP4) inhibitor for the treatment of type 2 diabetes mellitus.

YN481673 MB-07344 852947-39-8

MB-07344 is a potentthyroid hormone receptor (TR)-βagonist with a Ki of 2.17nM. MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin (HY-B0589) in rabbits, dogs and monkeys.