YN480450 MB-07811 852948-13-1

MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targetedthyroid hormone receptor-βagonist. MB-07811 has cholesterol and triglycerides lowering activity.

YN270012 SecinH3 853625-60-2

SecinH3 is a selective cytohesin inhibitor with IC50 of 2.4 μM, 5.4 μM, 5.4 μM, 5.6 μM, 5.6 μM, and 65 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, and yGea2-S7, respectively.

YN374156 Pyridoxal 5'-phosphate hydrat... 853645-22-4

Pyridoxal 5′-phosphate, a vitamin B6 phosphate, is a coenzyme in a variety of enzymatic reactions.

YN481078 A3334 854171-31-6

A3051 is a potent and orally active inhibtor ofCXXC5-DVLextracted from patent WO2020079569, has an IC50 of 63.06nM. A3334 can be used for the research of high fat diet (HFD)-induced and methionine-choline deficient diet...

YN481617 PF-915275 857290-04-1

PF-915275 is a potent, selective and orally activehuman 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1)inhibitor with a Ki of 2.3nM and an EC50 of 15nM (in HEK293 cells). The dose-dependent effect of PF-915275 on con...

YN321077 PSN632408 857652-30-3

PSN632408, a selective, orally activeGPR119agonist, shows similar potency to OEA at both recombinant mouse and human GPR119 receptors (EC50=5.6 and 7.9 uM, respectively). PSN632408 can stimulate β-cell replication an...

YN482442 2"-O-beta-L-galactopyranosyl... 861691-37-4

2"-O-beta-L-galactopyranosylorientin is extracted from the flowers ofTrollius ledebouri. 2"-O-beta-L-galactopyranosylorientin involves transporter mediated efflux in addition to passive diffusion and is the substrate of multidrug res...

YN360535 Empagliflozin 864070-44-0

Empagliflozin (BI-10773) is a potent and selective SGLT-2 inhibitor with IC50 of 3.1 nM, exhibits >300-fold selectivity over SGLT-1, 4, 5 and 6. Phase 3.

YN330205 Succinyl phosphonate trisodiu... 864167-45-3

Succinyl phosphonate trisodium salt is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts . Succinyl phosphonate trisodium salt is an 2-...

YN320329 TC-MCH 7c 864756-35-4

TC-MCH 7c, a phenylpyridone derivative, is an orally available, selective and brain-penetrableMCH1Rantagonist with an IC50 of 5.6nM for hMCH1R. TC-MCH 7c hasKis of 3.4nM and 3.0nM of human and mouse MCH1R, ...

YN1720041 HAEGTFTSDVS 864915-61-7

HAEGTFTSDVS is the first N-terminal 1-11 residues of GLP-1 peptide.

YN372298 Trelagliptin 865759-25-7

Trelagliptin is a highly selective, long-acting DPP-4 inhibitor. Phase 3.

YN370398 ONO-5334 868273-90-9

ONO-5334 is a potent, selective and orally activecathepsin Kinhibitor with Ki values of 0.10nM, 0.049nM and 0.85nM for human, rabbit and rat cathepsin K, respectively. ONO 5334 is an effective antiviral compound againstSA...

YN370252 Gosogliptin 869490-23-3

Gosogliptin is a potent and selective inhibitor ofdipeptidyl peptidase-IV(DPP-IV).

YN320301 Fasitibant chloride hydrochlo... 869880-33-1

Fasitibant chloride hydrochloride (MEN16132) is a potent, selective, high affinity, and longlasting nonpeptidebradykinin B2(BK2) receptorantagonist. Fasitibant chloride hydrochloride has proinflammatory effects and can be used...

YN1720020 MK 0893 870823-12-4

MK 0893 is a potent, selectiveglucagon receptorantagonist with IC50 of 6.6nM, and > 200 fold selectivity against GIPR, PAC1, GLP-1R, VPAC1 and VPAC2.

YN321168 Evocalcet 870964-67-3

Evocalcet has an activating effect oncalcium sensing receptor(CaSR) extracted from patent WO 2017061621 A1, compound A.

YN484026 Insulin alpha-chain (1-13) 872036-64-1

Insulin alpha-chain (1-13) is a human leucocyte antigen (HLA)-DR4-restricted epitope comprising the first 13 amino acids of the insulin A-chain.

YN484267 Compound 2 872313-42-3

Compound 2 is an active compound used for the research of metabolic bone diseases.

YN371573 3'-Hydroxy Repaglinide 874908-14-2

3'-Hydroxy Repaglinide is a main CYP2C8 metabolite of Repaglinide. Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes.