YN320404 Camicinal 923565-21-3

Camicinal (GSK962040) is a small molecule, selective motilin receptor agonist with pEC50 of 7.9.

YN290405 Elafibranor 923978-27-2

Elafibranor is an agonist of the peroxisome proliferator-activated receptor-α(PPAR-alpha) and peroxisome proliferator-activated receptor-δ(PPAR-δ). It improves insulin sensitivity, glucose homeostasis, and lipid metabolism and ...

YN321037 AdipoRon 924416-43-3

AdipoRon is a novel, and orally bioavailable adiponectin receptor agonist with KD of 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively.

YN310075 SRT 1720 925434-55-5

SRT 1720 is a selective activator of humanSIRT1with anEC1.5of 0.16μM, and shows less potent activities agaiinst SIRT2 and SIRT3 with EC1.5s of 37μM and > 300μM, respectively.

YN1720042 HAEGTFTSD 926018-45-3

HAEGTFTSD is a 9-residue peptide of human GLP-1 peptide or GLP-1(7-36), amide (HY-P0054A). GLP-1(7-36), amide is a physiological incretin hormone that stimulates insulin secretionin a glucose-dependant manner

YN1720043 HAEGTFT 926018-95-3

HAEGTFT is the first N-terminal 1-7 residues of GLP-1 peptide.

YN290060 Lanifibranor 927961-18-0

Lanifibranor (IVA-337) is a moderately potent and well balanced pan PPAR agonist with EC50 values of 1537 nM, 866 nM and 206 nM for hPPARα, hPPARδ and hPPARγ, respectively.

YN481408 Eliglustat hemitartrate 928659-70-5

Eliglustat hemitartrate (Genz-112638, Eliglustat tartrate) is a potent, specific and orally active inhibitor of glucosylceramide synthase with IC50 of 24 nM.

YN360903 Canagliflozin hemihydrate 928672-86-0

Canagliflozin hemihydrate is the hemihydrate form of canagliflozin, which is a SGLT2 inhibitor with IC50 of 2.2 nM for hSGLT2 in a cell-free assay, exhibits 413-fold selectivity over hSGLT1.

YN370404 DG051 929915-58-2

DG051 is a potentleukotriene A4 hydrolaseinhibitor of leukotriene B4 biosynthesis in the enzyme assay with anIC50=47nM.

YN290098 KD-3010 934760-92-6

KD-3010 is a potent, orally active, and selectivePPARδagonist.

YN372393 DGAT1-IN-3 939375-07-2

DGAT1-IN-3 is a potent, selective and orally bioavailable inhibitor ofDGAT-1, with IC50s of 38nM for hum and GAT-1 and 120nM for ratDGAT-1. DGAT1-IN-3 could be used to research of obesity, dyslipidemia, and m...

YN360684 GSK1016790A 942206-85-1

GSK1016790A is a potent and selectivetransient receptor potential vanilloid 4 (TRPV4)channel agonist. GSK1016790A can elicit Ca2+influx and elevate intracellular Ca2+in HEK cells.

YN290133 Pparδ agonist 942594-93-6

PPARδ agonist is aPPARδagonist extracted from patent US20180071304, compound example 10.

YN483500 12-Hydroxyganoderic Acid D 942950-96-1

12-Hydroxyganoderic Acid D is a triterpenoid extracted fromGanoderma lucidum.

YN372638 DGAT-1 inhibitor 2 942999-61-3

DGAT-1 inhibitor 2 is an effective inhibitor of DGAT-1;antiobesity agents. Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes that catalyze the final step in triglyceride synthesis. Findin...

YN372378 BMS-303141 943962-47-8

BMS-303141 is a potent, cell-permeable inhibitor of ATP-citrate lyase (ACL) with IC50 of 0.13 μM. BMS-303141 shows inhibition of total lipid syntheses with IC50 of 8 μM in HepG2 cells.

YN482972 7-O-Ethylmorroniside 945721-10-8

7-O-Ethylmorroniside is a iridoid glucoside from the fruit ofCornus officinaliswhich is a traditional medicine in China and used for the reserch of kidney diseases, including diabetic nephropathy.

YN370442 Apararenone 945966-46-1

Apararenone (MT-3995) is a novel non-steroidalmineralocorticoid receptorantagonists under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.

YN372352 LP-533401 945976-43-2

LP-533401 is aTryptophan hydroxylase 1inhibitor that regulates serotonin production in the gut.