YN360091 CDN1163 892711-75-0

CDN1163 is an allostericsarco/endoplasmic reticulum Ca2+-ATPase (SERCA)activator that improves Ca2+homeostasis. CDN1163 attenuates diabetes and metabolic disorders.

YN321007 APD597 897732-93-3

APD-597 (JNJ-38431055) is a potent and selective G protein-coupled receptor 119 (GPR119) agonist with EC50 of 46 nM for hGPR119 and an inhibitor of Cytochrome P450 2C9 (CYP2C9) with IC50 of 5.8 μM. A...

YN321777 Psoralenoside 905954-17-8

Psoralenoside is a benzofuran glycoside fromPsoralea corylifolia. Psoralenoside exhibits high binding affinities againsthistaminergic H1,calmodulin, and voltage-gated L-typecalcium channels(E-value≥-6.5 Kcal/mol). Psoralenoside ...

YN251776 Isopsoralenoside 905954-18-9

Isopsoralenoside is a benzofuran glycoside fromPsoralea corylifolia. Isopsoralenoside can be quickly metabolized to Psoralen (HY-N0053) in digestive tract contents. Isopsoralenoside show estrogen-like activity, osteoblastic prolife...

YN372232 Teneligliptin hydrobromide 906093-29-6

Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.

YN371129 KPLH1130 906669-07-6

KPLH1130 is a specific pyruvate dehydrogenase kinase (PDK) inhibitor, blocks macrophage polarization and attenuates proinflammatory responses. KPLH1130 improves glucose tolerance in HFD-fed mice.

YN371642 Levothyroxine acyl glucuronid... 909880-81-5

Levothyroxine acyl glucuronide (Thyroxine Acyl-β-D-glucuronide), an endogenous metabolite, is the acyl glucuronide formation of thyroxine (T4).

YN1720004 Semaglutide 910463-68-2

Semaglutide, a long-acting GLP-1 analogue, is a glucagon-like peptide-1(GLP-1)receptor agonist. Semaglutide has the potential for type 2 diabetes treatment.

YN371643 T3 Acyl glucuronide 910907-23-2

T3 Acyl glucuronide, an endogenous metabolite, is the acyl glucuronide formation of triiodothyronine (T3).

YN370492 AR-9281 913548-29-5

AR9281 is a potent and selective inhibitor ofsoluble epoxide hydrolase (s-EH), with potential for the treatment of hypertension and type 2 diabetes.

YN1720013 Exendin-4 acetate 914454-01-6

Exendin-4 acetate (Exenatide acetate), a 39 amino acid peptide, is a long-actingglucagon-likepeptide-1 receptor agonist with an IC50 of 3.22nM.

YN320346 MF498 915191-42-3

MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed strong binding affinity for the EP4 receptor with Ki of 0.7nM.

YN483111 Acanthopanaxoside B 915792-03-9

Acanthopanaxoside B is a triterpenoid saponin isolated from the leaves ofAcanthopanax senticosus.

YN290541 Naveglitazar racemate 916085-47-7

Naveglitazar racemate (LY519818 racemate) is the racemate of Naveglitazar. Naveglitazar is a nonthiozolidinedione peroxisome proliferator-activated receptor (PPAR) α-γ dual, γ-dominant agonist that has shown glucose-lowering pot...

YN372586 BMS-779788 918348-67-1

BMS-779788 is aLXRpartial agonist with IC50 values of 68nM for LXRα and 14nM for LXRβ.

YN321253 Setmelanotide 920014-72-8

Setmelanotide (RM-493, BIM-22493, CAM 4072) is a cyclic peptide full agonist of melanocortin-4 receptor (MC4R) with an EC50 of 0.27 nM and a Ki of 2.1 nM.

YN372345 MF-438 921605-87-0

MF-438 is a potent and orally bioavailablestearoyl-CoA desaturase 1 (SCD1)inhibitor with an EC50 of 2.3nM for rSCD1.

YN360735 Omeprazole D3 922731-01-9

Omeprazole D3 (H 16868 D3) is deuterium labeled Omeprazole. Omeprazole, aproton pumpinhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition ofCYP2C19activ...

YN450107 SAR407899 hydrochloride 923262-96-8

SAR407899 hydrochloride is a selective, potent and ATP-competitiveROCKinhibitor, with an IC50 of 135nM forROCK-2, and Kis of 36nM and 41nM for human and ratROCK-2, respectively.

YN450108 SAR407899 923359-38-0

SAR407899 is a selective, potent and ATP-competitiveROCKinhibitor, with an IC50 of 135nM forROCK-2, and Kis of 36nM and 41nM for human and ratROCK-2, respectively.