YN483468 Ascr#2 946524-24-9

Ascr#2 is an ascaroside isolated fromCaenorhabditis elegans, potently promotes dauer formation, and also acts as a potent male attractant combined with ascr#3 at low concentration.

YN320557 LMD-009 950195-51-4

LMD-009 is a selectiveCCR8nonpeptide agonist. LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC50s from 11 to 87nM.

YN483444 11-​Oxomogroside III 952481-53-7

11-Oxomogroside III is a cucurbitane triterpene glycoside isolated from in Siraitia grosvenorii fruits.

YN370169 GKT136901 955272-06-7

GKT136901 is a potent, selective and orally active inhibitor ofNADPH oxidase (NOX1/4), with Kis of 160 and 165nM, respectively. GKT136901 also is a selective and direct scavenger of peroxynitrite. GKT136901 can be u...

YN372389 Pradigastat 956136-95-1

Pradigastat (LCQ-908) is a potent, selective and orally activediacylglycerol acyltransferase 1 (DGAT1)inhibitor. Pradigastat has anti-obesity and anti-diabetic effects.

YN480767 FPH2 957485-64-2

FPH2 (BRD-9424) is a small molecule, which promotes differentiation of iPS-derived hepatocytes.

YN370038 A 922500 959122-11-3

A922500 is an inhibitor for human and mouse DGAT-1 with IC50 of 7 nM and 24 nM, respectively, good selectivity over related acyltransferases, hERG, and a panel of anti-targets.

YN372470 PF 750 959151-50-9

PF 750 is a selective and covalentfatty acid amide hydrolase (FAAH)inhibitor, with IC50 svaried from 16.2-595nM in different pre-incubation times. Covalently modifies the enzyme’s active site serine nucleophile.

YN360149 Dapagliflozin ((2S)-1,2-prop... 960404-48-2

Dapagliflozin propanediol belongs to the class of orally administered antidiabetic agents designated as sodiumglucose cotransporter 2 (SGLT2) inhibitors.

YN320274 Fasiglifam 1000413-72-8

Fasiglifam (TAK-875) is a potent, selective and orally bioavailableGPR40agonist withEC50of 72nM.

YN480211 BMS-816336 1009583-20-3

BMS-816336 is a novel, potent and orally bioavailable inhibitor againsthuman 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzymewith an IC50 of 3.0nM.

YN480212 (R)-BMS-816336 1009583-83-8

(R)-BMS-816336 (Compound 6n-1) is a potent and orally active inhibitor ofhuman,mouse and cynomolgus monkey 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzymewith IC50s of 14.5nM, 50.3nM and 16nM, respectively.

YN480528 S-23 1010396-29-8

S-23 is an orally active selective and rogen receptormodulator (SARM) with a Ki of 1.7nM. S-23 induces and rogen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and ...

YN290037 GSK376501A 1010412-80-2

GSK376501A is a selective peroxisome proliferator-activated receptor gamma (PPARγ) modulator for the treatment of type 2 diabetes mellitus.

YN330122 TFAP 1011244-68-0

TFAP is a selective and cell-permeable cyclooxygenase-1 (COX-1) inhibitor with IC50 of 0.8 μM.

YN320615 AM-4668 1011531-27-3

AM-4668 is aGPR40agonist for type 2 diabetes.EC50s of 3.6nM and 36nM for GPR40 in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), respectively.

YN290187 GSK0660 1014691-61-2

GSK0660 is a potent PPARβ/δ antagonist with a pIC50 of 6.8 (binding assay IC50 = 155 nM; antagonist assay IC50 = 300 nM) and is nearly inactive on PPARα and PPARγ with IC50s above approximately 10 μM.

YN370481 CVT-12012 1018675-35-8

CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase(SCD)inhibitor, with IC50s of 38nM, 6.1nM for rat microsomal and human HEPG2, respectively.

YN321019 Cort108297 1018679-79-2

Cort108297 is a specificglucocorticoid receptor(GR) antagonist. Cort108297 has a high affinity for GRs with a Ki of 0.45nM.

YN360546 Sotagliflozin 1018899-04-1

Sotagliflozin (LX4211) is an oral dual SGLT1/SGLT2 inhibitor with IC50 of 36 nM and 1.8 nM, respectively. Phase 3.