YN320968 SB-269970 hydrochloride 261901-57-9

SB269970 HCl is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors.

YN361033 CALP3 261969-05-5

CALP3, a Ca2+-like peptide, is a potentCa2+channelblocker that activates EF h and motifs of Ca2+-binding proteins. CALP3 can functionally mimic increased [Ca2+]iby modulating the activity of Calmodulin (CaM), Ca2+channels...

YN320863 Fosaprepitant dimeglumine 265121-04-8

Fosaprepitant is a water-soluble phosphoryl prodrug for Aprepitant which is a NK1 antagonist.

YN320937 Pardoprunox hydrochloride 269718-83-4

Pardoprunox (SLV-308, DU-126891, SME-308) hydrochloride (HCl) is a potent but partial dopamine D2 receptor agonist with pEC50 of 8.0, and a partial agonist in the induction of [³⁵S]GTPγS binding ...

YN320936 Pardoprunox 269718-84-5

Pardoprunox (SLV-308) is a partialdopamine D2 and D3 receptorpartial agonist and aserotonin 5-HT1A receptoragonist, withpEC50s of 8, 9.2, and 6.3, respectively.

YN340105 ZM39923 273727-89-2

ZM39923 is aJAK3inhibitor, with apIC50 of 7.1; ZM39923 also potently inhibits tissue transglutaminase (TGM2) with an IC50 of 10nM.

YN372597 4-Ethynyl-L-phenylalanine 278605-15-5

4-Ethynyl-L-phenylalanine is a selective, reversible, potent and competitive inhibitor oftryptophan hydroxylase (TPH). 4-Ethynyl-L-phenylalanine is a competitive inhibitor with regard to the substrate tryptophan, with a Ki of 32.6...

YN420100 SB 216763 280744-09-4

SB216763 is a potent and selective GSK-3 inhibitor with IC50 of 34.3 nM for GSK-3α and equally effective at inhibiting human GSK-3β.

YN320650 Ro 64-6198 280783-56-4

Ro 64-6198 is a potent, selective, nonpeptide, high-affinity, high cellular permeability and brain penetrationN/OFQ receptor (NOP)agonist with an EC50 value of 25.6nM. Ro 64-6198 is at least 100 times more selective for the N...

YN481088 FK962 283167-06-6

FK962 is an enhancer ofsomatostatin release, exerts cognitive-enhancing actions. Anti-dementia properties.

YN361086 L-838417 286456-42-6

L-838417 is a selective partial agonist at theα2, α3 and α5 subtypesof the GABAAreceptor and an antagonist at the α1, with bindingKivalues of 0.79nM, 0.67nM, 1.67nM, 267nM, 2.25nM and 2183nM for α1β3γ2, α2β3γ2, ...

YN321298 Fesoterodine 286930-02-7

Fesoterodine is an orally active, nonsubtype selective, competitivemuscarinic receptor (mAChR)antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine is used for the over...

YN321335 Fesoterodine fumarate 286930-03-8

Fesoterodine Fumarate is a prodrug of 5-hydroxymethyl tolterodine that is a muscarinic AChR receptor antagonist, used to treat overactive bladder syndrome.

YN321301 SB-408124 288150-92-5

SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor.

YN484160 RAD16-I 289042-25-7

RAD16-I, a soft nanofibrous self-assembling peptide, is a suitable microenvironment for human mesenchymal stem cells’ (hMSC) proliferation and differentiation into chondrocytes. RAD16-I is a well-studied ionic complementary pe...

YN370333 Arimoclomol 289893-25-0

Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via t...

YN370334 Arimoclomol maleate 289893-26-1

Arimoclomol maleate (BRX-220) is a co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the...

YN360430 TRAM-34 289905-88-0

TRAM-34 is a highly selective blocker of intermediate-conductance calcium-activated K+channel (IKCa1) (Kd=20nM).

YN373005 Netupitant metabolite N-desm... 290296-72-9

N-desmethyl Netupitant is a metabolite of Netupitant, which is an antiemitic drug.

YN321060 Netupitant 290297-26-6

Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity.