YN1730025 SB-277011 215803-78-4

SB-277011 is a potent and delective dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively); brain penetrant.

YN320363 SB-277011 hydrochloride 215804-67-4

SB-277011 hydrochloride (SB-277011A hydrochloride) is a potent, selective, orally bioavailable and brain penetratedopamine D3receptor (D3R)antagonist with Ki values of 10.7 nM and  11.2nM at rodent and human D3R, resp...

YN360345 CX546 215923-54-9

CX546 is a first-generation and selective benzamide-type positiveAMPARmodulator. CX546 is a prototypical ampakine agent and has antipsychotic effects.

YN361038 β-Pompilidotoxin 216064-36-7

β-Pompilidotoxin (β-PMTX), a wasp venom, can slowsodium channelinactivation and increases steady-state sodium current in cells.

YN361044 α-Conotoxin AuIB 216299-21-7

α-Conotoxin AuIB, a potent and selectiveα3β4nicotinic acetylcholine receptor (nAChR) antagonist, blocks α3β4 nAChRs expressed inXenopusoocytes with an IC50 of 0.75μM.

YN360132 PD173212 217171-01-2

PD173212 is a selectiveN-type voltage sensitive calcium channel (VSCC)blocker, with an IC50 of 36nM in IMR-32 assays.

YN320367 L-803087 217480-26-7

L-803087 is a potent and selectivesomatostatin sst4 receptoragonist with a Ki of 0.7nM. L-803087 is >280-fold higher than other somatostatin receptors. L-803087 facilitates AMPA-mediated hippocampal synaptic responses in vitro a...

YN484106 MOG (89-113), human 218291-36-2

MOG (89-113), human is a peptide fragment of human myelin oligodendrocyte glycoprotein.

YN380287 BDNF(human) 218441-99-7

BDNF (human) is aneurotrophinin the central nervous system  and mediates survival and differentiation of neurons. BDNF (human) binds toTrkB and leads to the dimerization and autophosphorylation of tyrosine residues in the i...

YN380064 ANA-12 219766-25-3

ANA-12 is a selective TrkB antagonist with Kd of 10 nM and 12 μM for the high and low affinity sites, respectively.

YN360163 Radequinil 219846-31-8

Radequinil (AC-3933) is a benzodiazepine receptor (BzR) partial inverse agonist. AC-3933 binds toGABA(-) and GABA(+) lig and with Kis of 5.15 and 6.11nM, respectively.

YN380097 Escitalopram oxalate 219861-08-2

Escitalopram Oxalate is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.

YN320896 MPEP Hydrochloride 219911-35-0

MPEP Hydrochloride is a potent, selective, noncompetitive, orally active and systemically activem Glu5 receptorantagonist, with an IC50 of 36nM for completely inhibiting quisqualate-stimulated phosphoinositide (PI) hydrolysis. ...

YN322078 Revexepride 219984-49-3

Revexepride is a highly selective5-HT4 receptoragonist, and a potential inducer ofCYP3A4 enzyme, used for the treatment of gastroesophageal reflux disease.

YN320313 AR-A 2 220051-79-6

AR-A 2 is a selective5-HT1Breceptorantagonist, with high affinity to guinea pig cortex5HT1B/1D and recombinant guinea pig5-HT1Breceptors(Ki=0.24 and 0.47nM) and with 10-fold lower affinity to guinea pig5-HT1Dreceptor(...

YN1730119 A-437203 220519-06-2

A-437203 is a selectiveD3receptor antagonist with Kiof 71, 1.6, and 6220nM for D2, D3, and D4receptors, respectively.

YN360696 DAA-1106 220551-92-8

DAA1106 is a potent and selective lig and for peripheral benzodiazepine receptor (PBR), as a potent and selective agonist at the peripheral benzodiazepine receptor.

YN320538 p-MPPI hydrochloride 220643-77-6

p-MPPI hydrochloride is a selective5-HT1A receptorantagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects.

YN360411 Rivanicline oxalate 220662-95-3

Rivanicline oxalate (RJR-2403 oxalate; (E)-Metanicotine oxalate) is aneuronal nicotinic receptoragonist, showing high selectivity for the α4β2 subtype (Ki=26nM); > 1,000 fold selectivity than α7 receptors(Ki= 3.6μM).

YN321850 Antisauvagine-30 220673-95-0

Antisauvagine-30 (aSvg-30) is a potent, competitive and selectiveCRF2receptorantagonist withKdvalues of 1.4nM and 153.6nM for mouse CRF2β and rat CRF1receptors, respectively.