YN321914 [cPP1-7,NPY19-23,Ala31,A... 313988-89-5

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selectiveneuropeptide Y Y5receptor agonist with an IC50 of 0.24nM for binding to the hY5receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPa...

YN360636 Sunifiram 314728-85-3

Sunifiram (DM-235) is a piperazine derived ampakine-like drug which has nootropic effects in animal studies with significantly higher potency than piracetam.

YN1730023 BP 897 314776-92-6

BP 897 is a potent and selectivedopamine D3 receptoragonist, and a weakdopamine D2 receptorantagonist, with Kis of 0.92nM and 61nM for D3 and D2 receptors, and shows low affinities at D1 and D4 receptors (Kis, 3 and...

YN484021 β-Amyloid Protein Precurso... 315229-44-8

β-Amyloid Protein Precursor 770 (135-155) is a peptide of amyloid precursor protein isoform (APP 770). APP 770 produces Aβ40/42.

YN380288 β-Amyloid (42-1), human 317366-82-8

β-Amyloid (42-1), human is the inactive form of Amyloid β Peptide (1-42). Amyloid β Peptide (42-1) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.

YN280031 CCT020312 324759-76-4

CCT020312 is a selectiveEIF2AK3/PERKactivator. CCT020312 elicits EIF2A phosphorylation in cells.

YN360321 ICA-27243 325457-89-4

ICA-27243 is a selective, potent and orally activeKCNQ2/Q3 potassium channelopener with an EC50 of 0.38μM. ICA-27243 is less effective at activating KCNQ4 and KCNQ3/Q5. ICA-27243 has antiepileptic and antico...

YN360244 NS19504 327062-46-4

NS19504 is a Ca2+-activated K+channel (BK channel, KCa1.1 channel) activator (EC50=11.0 µM) with relaxing effect on bladder smooth muscle spontaneous phasic contractions.

YN373006 Quetiapine sulfoxide dihydroc... 329218-11-3

Quetiapine sulfoxide dihydrochloride (Quetiapine S-oxide dihydrochloride) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagon...

YN484130 Tau Peptide (275-305) (Repe... 330456-25-2

Tau Peptide (275-305) (Repeat 2 domain) is the Alzheimer's tau fragment R2, corresponding to the second repeat unit of the microtubule-binding domain, which is believed to be pivotal to the biochemical properties of full tau protein.

YN310042 AK-1 330461-64-8

AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor, with an IC50 of 12.5μM.

YN360507 Chembridge-5861528 332117-28-9

Chembridge-5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx (IC50 values are 14.3 and 18.7μM respectively).

YN370476 HFI-142 332164-34-8

HFI-142 is aninsulin-regulated aminopeptidase (IRAP)inhibitor with a Ki of 2.01μM.

YN380045 LX2343 333745-53-2

LX2343 is a multi-target agent that exhibits a high capability for ameliorating multi-abnormalities of AD pathogenesis. It is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM.

YN320405 5-HT7 agonist 1 334974-31-1

5-HT7 agonist 1 is a selective5-HT7 receptoragonist, with an IC50 of 222.93nM, can be used for the 5-HT7 receptor related disease, such as CNS disorders.

YN330179 CAY10404 340267-36-9

CAY10404 is a potent and highly selectivecyclooxygenase-2 (COX-2)inhibitor with an IC50 of 1nM. CAY10404 exhibits no inhibition of COX-1 (IC50>500 µM). CAY10404 is a potent inhibitor ofPKB/Akt and MAPKsignali...

YN350038 LM22B-10 342777-54-2

LM22B-10 is an activator ofTrkB/TrkCneurotrophin receptor, and can induceTrkB,TrkC,AKT and ERKactivation in vitro and in vivo.

YN321926 OXA(17-33) 343268-91-7

OXA(17-33) is a potent and selectiveorexin-1 receptor (OX1)agonist. OXA(17-33) shows a ∼23-fold selectivity for the OX1 (EC50=8.29nM) over OX2 (187nM).

YN481773 Sugammadex sodium 343306-79-6

Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery in adults.

YN360218 NS3623 343630-41-1

NS3623 is an activator ofhuman ether-a-go-go-related gene (hERG1/KV11.1) potassium channels. NS3623 activates theIKr and Itocurrents and has antiarrhythmic effect. NS3623 has a dual mode of action, being an inhibitor of hER...