YN380145 BMS 299897 290315-45-6

BMS 299897 is a sulfonamideγ-secretaseinhibitor with an IC50 of 7nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).

YN380134 L-685458 292632-98-5

L-685,458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.

YN360252 Dianicline dihydrochloride 292634-27-6

Dianicline dihydrochloride is aα4β2 nicotinic acetylcholine receptorpartial agonist, a class of drugs that includes varenicline and cytisine for smoking cessation. Dianicline dihydrochloride increases cessation rates in a dose-depende...

YN370262 Ro 90-7501 293762-45-5

Ro 90-7501 is anamyloid β42(Aβ42) fibril assemblyinhibitor that reducesAβ42-induced cytotoxicity (EC50of 2μM). Ro 90-7501 inhibitsATMphosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (...

YN270365 (R)​-​CR8 294646-77-8

(R)​-​CR8 (CR8), a second-generation analog of Roscovitine, is a potentCDK1/2/5/7/9inhibitor. (R)​-​CR8 inhibits CDK1/cyclin B (IC50=0.09μM), CDK2/cyclin A (0.072μM), CDK2/cyclin E (0.041μM), CDK5/p25 ...

YN320564 S26131 296280-56-3

S26131 (compound 5) is a potent and selectiveMT1melatoninergic lig and , and theKivalues are 0.5 and 112nM for MT1 and MT2, respectively. S26131 behaves as an MT1 and MT2 antagonist.

YN360146 ML402 298684-44-3

ML402, a thiophene-carboxamide, is a selectiveK2P2.1(TREK-1) and K2P10.1(TREK-2)activator. ML402 is inactive against K2P4.1(TRAAK).

YN320230 NPS ALX Compound 4a 299433-10-6

NPS ALX Compound 4a is a potent and selective5-hydroxytryptamine6(5-HT6) receptorantagonist, with an IC50 of 7.2nM and a Ki of 0.2nM.

YN1730035 (+)-PD 128907 hydrochloride 300576-59-4

(+)-PD 128907 hydrochloride is a selective dopamineD2/D3receptor agonist, with Kisof 1.7, 0.84nM for human and rat D3receptors, 179, 770 n M for human and rat D3receptors, respectively.

YN321189 RS102895 300815-41-2

RS102895 is a potentCCR2antagonist, with an IC50 of 360nM, and shows no effect on CCR1.

YN481519 P7C3 301353-96-8

P7C3 is a potent proneurogenic and neuroprotective chemical that targets NAMPT enzyme.

YN321972 Neuropeptide Y(29-64) 303052-45-1

Neuropeptide Y(29-64) is a 36 amino acid peptide, a fragment of Neuropeptide Y.

YN320076 HT-2157 303149-14-6

HT-2157 (SNAP 37889) is a selective, high-affinity, competitive antagonists ofgalanin-3 receptor(Gal3).

YN420258 SC79 305834-79-1

SC79 is a brain-penetrable Akt phosphorylation activator and an inhibitor of Akt-PH domain translocation.

YN483798 Crustacean Cardioactive Pep... 309247-84-5

Crustacean Cardioactive Peptide (CCAP) is a highly conserved, amidated cyclic nonapeptide, first isolated from the pericardial organs of the shore crab Carcinus maenas, where it has a role in regulating heartbeat; Crustacean Cardi...

YN321883 RFRP-3(human) 311309-27-0

RFRP-3 (Neuropeptide VF(124-131))(human), a humanGnIH peptidehomolog, is a potent inhibitor ofgonadotropin secretionby inhibiting Ca2+mobilization. RFRP-3(human) is aNPFF1 receptoragonist, it inhibits forskolin-induced p...

YN320844 Indacaterol 312753-06-3

Indacaterol is an ultra-long-acting β-adrenoceptor agonist with pKi of 7.36 for β1-adrenoceptor and pKi of 5.48 for β2-adrenoceptor.

YN480955 P7C3-OMe 313268-18-7

P7C3-OMe is a pro-neurogenic compound, has therapeutic benefits in neuropsychiatric and /or neurodegenerative disease. The R-enantiomer of P7C3-OMe is far more active than the S-enantiomer.

YN480603 CID 1375606 313493-80-0

CID 1375606 is a surrogate agonist of orphan G protein-coupled receptorGPR27.

YN320237 PU02 313984-77-9

PU02, a derivative of 6-MP (HY-13677), is a negative allosteric modulator (NAM) of5-HT3receptor, with IC50 values of 0.36 and 0.73μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respective...