Chemical structure
Cat.No.
Product Name
CAS no.
Target
NEP-IN-1 is a neutral endopeptidase (NEP) inhibitor with IC50 of 2nM fordNEP.
YN320853 Idalopirdine Hydrochloride 467458-02-2
Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) is a potent and selective5-HT6 receptorantagonist with a Ki of 0.83nM.
MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM. Phase 1/2.
YN320376 2-Methylthioadenosine diphosp... 475193-31-8
2-Methylthioadenosine diphosphate trisodium is a potentpurinergic P2Yreceptors agonist, with EC50s of 19, 6.2, and 5nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium ...
YN371095 Mebeverine acid 475203-77-1
Mebeverine acid is a metabolite of Mebeverine, which is a musculotropic antispasmodic drug.
A-317491 is a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors with Ki values of 22 nM and 9 nM for human P2X3 and P2X2/3 receptors.
YN321574 (R,R)-Glycopyrrolate 475468-09-8
(R,R)-Glycopyrrolate ((R,R)-Glycopyrronium (bromide); (R,R)-Glycopyrrolate (bromide)) is ananticholinergicagent. (R,R)-Glycopyrrolate ((R,R)-Glycopyrronium (bromide); (R,R)-Glycopyrrolate (bromide)) has the ability to redu...
YN380301 β-Amyloid (4-10) 477284-32-5
β-Amyloid (4-10) is an epitope for the polyclonal anti-Aβ(1-42) antibody, reduces amyloid deposition in a transgenic Alzheimer disease mouse model.
cis-ACPD is a potent agonist of NMDA receptor, with an IC50 of 3.3μM. cis-ACPD is also a selective agonist ofgroup II mGluR, with EC50s of 13μM and 50μM formGluR2 and mGluR4, respectively.
YN360573 Gabapentin enacarbil 478296-72-9
Gabapentin enacarbil (XP-13512) is a prodrug for the anticonvulsant and analgesic drug gabapentin.
YN360509 CNQX disodium 479347-85-8
CNQX disodium (FG9065 disodium) is a potent and competitiveAMPA/kainate receptorantagonist with IC50s of 0.3μM and 1.5μM, respectively. CNQX disodium is a competitivenon-NMDA receptorantagonist. CNQX disodium...
YN360512 NBQX disodium 479347-86-9
NBQX disodium (FG9202 disodium) is a highly selective and competitiveAMPA receptorantagonist. NBQX disodium has neuroprotective and anticonvulsant activity.
YN320391 SB-674042 483313-22-0
SB-674042 is a potent and selective non-peptide orexin OX1 receptor antagonist (Kd = 3.76nM); exhibits 100-fold selectivity for OX1 over OX2 receptors. SB-674042 has no effect at serotonergic, dopaminergic, adrenergic or puri...
YN450093 Purmorphamine 483367-10-8
Purmorphamine, which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo with IC50 of ~ 1.5 μM in HEK293T cell and also is an inducer of osteoblast differentiation with EC50 of 1 μM.
AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, activating Wnt signaling, increases bone mass in rats.
CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit.
YN280052 LC3-mHTT-IN-AN1 486443-73-6
LC3-mHTT-IN-AN1 (Compound AN1) is amHTT-LC3linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces ...
ARN272 is anan and amide transportinhibitor.
ML213 is a selective activator ofKv7.2 and Kv7.4channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510nM, respectively.
YN321863 Hemokinin 1, human 491851-53-7
Hemokinin 1, human is a selective tachykininneurokinin 1 (NK1)receptor full agonist. Hemokinin 1, human is a full agonist atNK2 and NK3receptor. Hemokinin 1, human can produces an opioid-independent analgesia.
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