Chemical structure
Cat.No.
Product Name
CAS no.
Target
DB04760 (compound 4) is a potent, highly selective, non-zinc-chelatingMMP-13inhibitor with an IC50 of 8nM. DB04760 significantly reduces paclitaxel neurotoxicity and has anticancer activity.
QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM in Jurkat T cells, respectively.
AMG-9810 is potent, competitive and selective vanilloid receptor 1 (TRPV1) antagonist and inhibits capsaicin activation with IC50 of 24.5 nM and 85.6 nM for human TRPV1 and rat TRPV1, repectively. AMG-9810 block...
URB597 is a potent, orally bioavailable FAAH inhibitor with IC50 of 4.6 nM, with no activity on other cannabinoid-related targets. Phase 1.
ERB-196 is a nonsteroidal selectiveestrogen receptor-β(ERβ) agonist.
YN360538 Encenicline hydrochloride 550999-74-1
Encenicline hydrochloride (EVP-6124 hydrochloride) is a novel partial agonist ofα7neuronal nicotinic acetylcholine receptors (nAChRs).
YN320855 WAY-181187 554403-49-5
WAY-181187 (SAX-187) is a potent and selective full5-HT6receptor agonist with a Ki of 2.2nM and an EC50 of 6.6nM. WAY181187 mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinas...
AC260584 is anM1muscarinic receptor allosteric agonist with a pEC50 of 7.6.
YN380046 4-(6-Bromo-2-benzothiazolyl)b... 566169-97-9
4-(6-Bromo-2-benzothiazolyl)benzenamine is aβ-amyloidPET (positron emission tomography) tracer that can be used in the diagnosis of neurological diseases, such as Alzheimer's and Down's syndrome.
YN321846 Hemopressin(rat) 568588-77-2
Hemopressin(rat) is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin(rat) is orally active, selective and inverse agonist ofCB1cannabinoid receptors. Hemopressin(r...
YN360081 ICA-069673 582323-16-8
ICA-069673 is aKCNQ2/Q3potassium channel activator with an IC50 of 0.69μM.
YN371097 O-desmethyl Mebeverine acid 586357-02-0
O-desmethyl Mebeverine acid is a metabolite of Mebeverine, which is a musculotropic antispasmodic drug.
YN320093 Olcegepant hydrochloride 586368-06-1
Olcegepant hydrochloride (BIBN-4096 hydrochloride) is a potent and selective non-peptide antagonist of thecalcitonin gene-related peptide 1 (CGRP1) receptor with IC50 of 0.03nM and with a Ki of 14.4 pM for human CGRP.
YN370771 3-O-Methyldopa D3 586954-09-8
3-O-Methyldopa D3 (3-Methoxy-L-tyrosine D3) is deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits th...
YN1730018 ABT-724 trihydrochloride 587870-77-7
ABT-724 trihydrochloride is a potent and highly selectivedopamine D4receptoragonist with an EC50 of 12.4nM forhuman dopamine D4receptor. ABT-724 trihydrochloride is a potent partial agonist at therat D4(EC50of 14.3nM) and ...
YN481403 Tafamidis 594839-88-0
Tafamidis is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs.
TWS119 is a GSK-3β inhibitor with IC50 of 30 nM in a cell-free assay capable of inducing neuronal differentiation and may be useful to stem cell biology.
YN380139 Azeliragon 603148-36-3
Azeliragon (TTP488) is an orally bioavailable small molecule that inhibits the receptor for advanced glycation endproducts (RAGE), which is an immunoglobulin-like cell surface receptor overexpressed in brain tissues of patien...
YN360224 AZ10606120 dihydrochloride 607378-18-7
AZ10606120 dihydrochloride is a selective, high affinity antagonist forP2X7 receptor (P2X7R)at human and rat with an IC50 of ~10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 di...
YN320854 Intepirdine 607742-69-8
SB742457 is a highly selective 5-HT6 receptor antagonist with pKi of 9.63, exhibits >100-fold selectivity over other receptors. Phase 2.
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