YN360501 Radiprodil 496054-87-6

Radiprodil (RGH-896) is a NR2B-selective NMDA receptor antagonist, initially developed for the treatment of neuropathic pain.

YN320154 NEO 376 496921-73-4

NEO 376 is a selective modulator of 5-HT1 receptor,GABA receptor and dopamine receptor, with anti-psychotic actively.

YN310166 TPPB 497259-23-1

TPPB is a cell-permeable benzolactam-derived protein kinase C (PKC) activator with a Ki of 11.9nM.

YN360313 NS 1738 501684-93-1

NS 1738 (NSC 213859) is a novel positive allosteric modulator of theα7 nAChR, with respect to positive modulation of α7 nAChR (EC50=3.4μM in oocyte experiments).

YN360314 PNU-120596 501925-31-1

PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.

YN360165 SB-705498 501951-42-4

SB705498 is a TRPV1 antagonist for hTRPV1, antagonizes capsaicin, acid, and heat activation of TRPV1 with IC50 of 3 nM, 0.1 nM and 6 nM, shows a degree of voltage dependence, exhibits >100-fold selectivity for TRPV1 o...

YN420181 SAR502250 503860-57-9

SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor ofGSK3, with an IC50 of 12nM forhuman GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for ...

YN320978 Vortioxetine 508233-74-7

Vortioxetine, a novel antidepressant for the treatment of major depressive disorder, is a 5-HT3, 5-HT7 and 5-HT1D receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and serotonin (5-HT) transporter...

YN320292 SRX246 512784-93-9

SRX246 is a potent, CNS-penetrant, highly selective, orally bioavailablevasopressin 1a (V1a) receptorantagonist (Ki=0.3nM for human V1a). SRX246 has no interaction at V1b and V2 receptors. SRX246 also displays negligible...

YN361030 COG 133 514200-66-9

COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also anAChRant...

YN290425 Fonadelpar 515138-06-4

Fonadelpar is aPPARδagonist, used in the research of neuroparalytic keratopathy.

YN380127 Edonerpic maleate 519187-97-4

Edonerpic maleate is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ).

YN270603 Z-LEHD-FMK TFA 524746-03-0

Z-LEHD-FMK TFA is a selective and irreversible inhibitor ofcaspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK TFA exhibits the neuroprotective effect in a rat model of spinal...

YN320604 Methoxy-PEPy 524924-76-3

Methoxy-PEPy is a potent and highly selective mGlu5 receptor antagonist with IC50 of 1nM. Administration of [3H]methoxy-PEPy (50 microCi/kg i.v.) to mGlu5 receptor-deficient mice revealed binding at background levels in for...

YN361040 Huwentoxin-IV 526224-73-7

Huwentoxin-IV is a potent and selectivesodium channelblocker, inhibits neuronalNav1.7,Nav1.2,Nav1.3 and Nav1.4with IC50s of 26, 150, 338 and 400nM, respectively. Huwentoxin-IV preferentially blocks peripheral nerve subtype ...

YN321925 [Ala11,D-Leu15]-Orexin B(... 532932-99-3

[Ala11,D-Leu15]-Orexin B(human) is a potent and selectiveorexin-2 receptor (OX2)agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 (EC50=0.13nM) over OX1 (52nM).

YN481620 Erteberel 533884-09-2

Erteberel (LY500307) is a potent and selective estrogen receptor beta (ERβ) agonist withKi and EC50of 1.54nM and 3.61nM, respectively. Anti-tumor activities.

YN290008 NKL 22 537034-15-4

NKL 22 is a selective inhibitor of HDAC with IC50 of 78 µM.

YN320952 Mavoglurant 543906-09-8

Mavoglurant (AFQ056) is a potent, selective, non-competitive and orally activemGluR5antagonist, with an IC50 of 30nM. Mavoglurant shows a >300 fold selectivity for the mGluR5 over all targets (238) tested. Mavoglurant can be ...

YN360464 COR659 544450-68-2

COR659 is a potent and effectiveGABABpositive allosteric modulator (PAM). COR659 suppresses alcohol and chocolate self-administration in rats.