YN320915 Tasimelteon 609799-22-6

Tasimelteon is a melatonin MT1 and MT2 receptor agonist.

YN420186 AZD1080 612487-72-6

AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor, inhibits human GSK3α and GSK3β with Ki of 6.9 nM and 31 nM, respectively, shows >14-fold selectivity against CDK2, CDK5, CDK1 and Erk2.

YN320503 CB1 antagonist 2 614726-85-1

CB1 antagonist 2 is caimabinoid 1 (CB1) antagonist extracted from patent WO2016184310A1, compound 3, inhibits CB1 in vivo with an IC50 of 25.5nM.

YN483737 Argireline 616204-22-9

Argireline (Acetyl hexapeptide-3) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline significantly inhibits Ca2+dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline has antiwrinkle ...

YN370499 AZD5904 618913-30-7

AZD5904 is a potent and irreversible inhibitor of humanMyeloperoxidase(MPO) with an IC50 of 140nM and has similar potency in mouse and rat.

YN483188 Bacopaside V 620592-16-7

Bacopaside V is a bioactive triterpenoid glycoside ofBacopa monniera, a herb having confirmed nervine tonic activity.

YN321086 Tradipitant 622370-35-8

Tradipitant (VLY-686) is aneurokinin-1(NK-1) antagonist.

YN1730087 PD-168077 maleate 630117-19-0

PD-168077 maleate is a selective dopamineD4receptor agonist, with aKiof 9nM.

YN380307 β-Amyloid (33-40) 634204-57-2

β-Amyloid (33-40) is a peptide consisting of amino acid of 33 to 40 of beta amyloid protein.

YN320892 TBPB 634616-95-8

TBPB is an allosteric M1 mAChR agonist(EC50=289nM) that regulates amyloid processing and produces antipsychotic-like

YN480638 AER-271 634913-39-6

AER-271, a phosphonate prodrug derivative of AER-270, is anaquaporin-4(AQP4) inhibitor for the research of acute ischemic stroke.

YN321288 LY404039 635318-11-5

LY404039 is a potent agonist of recombinant human mGlu2/mGlu3 receptors with Ki of 149 nM/92 nM, shows >100-fold selectivity over ionotropic glutamate receptors, glutamate transporters, and other receptors. Phase 3.

YN320277 Pomaglumetad methionil hydroc... 635318-26-2

Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia resea...

YN320887 Pomaglumetad methionil anhydr... 635318-55-7

Pomaglumetad methionil anhydrous (LY2140023) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. LY2140023 has the potential for schizophrenia research.

YN321251 F-15599 635323-95-4

F-15599 is a highly selective G-protein biased5-HT1A receptoragonist, with Kiof 3.4nM.

YN360168 Salfaprodil free base 640290-67-1

Salfaprodil free base (Neu2000) is an NR2B-selective and uncompetitive antagonist ofN-methyl-D-aspartate (NMDA), and a free radical scavenger. Salfaprodil free base has excellent neuroprotection againstnMDA- and free ra...

YN481017 Jedi2 651005-90-2

Jedi2 is aPiezo1channel activator, but no specific Piezo2 activators. Jedi2 binds to the mouse Piezo1 proteins with a Kdof 2770  μM.

YN360166 AMG 517 659730-32-2

AMG 517 is a potent and selective TRPV1 antagonist, and antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM， respectively.

YN321140 Levalbuterol tartrate 661464-94-4

Levalbuterol HCl is a relatively selective beta2-adrenergic receptor agonist used for the treatment of asthma.