YN483874 Neuropeptide S (human) 412938-67-1

Neuropeptide S human is a potent endogenousneuropeptide S receptoragonist (EC50= 9.4nM). Neuropeptide S human increases locomotor activity and wakefulness in mice. Neuropeptide S human also reduces anxiety-like behavior in mice.

YN370222 Rilapladib 412950-08-4

Rilapladib (SB 659032) is a selectiveLp-PLA2(lipoprotein-associated phospholipase A2) inhibitor with an IC50 of 230 pM. Rilapladib (SB 659032) is also a PAFR (Platelet Activating Factor Receptor) antagonist.

YN310295 AK-7 420831-40-9

AK 7 is a brain-permeable selective SIRT2 inhibitor with an IC50 of 15.5 μM.

YN380002 Semagacestat 425386-60-3

Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM in H4 human glioma cell. Phase 3.

YN481637 HQ-415 430462-93-4

HQ-415 is a class of clinically relevant bioactive metal chelators related to clioquinol. The effective concentration eliciting a EC50 for HQ-415 is 15μM. IC50 value: 15μM (EC50) in vitro: In TDP-43-expressing cells, CQ...

YN250044 4E2RCat 432499-63-3

4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5μM.

YN370463 BRL-50481 433695-36-4

BRL-50481 is a novel and selective inhibitor of phosphodiesterase (PDE) 7 with a Ki value, derived from secondary (Dixon) plots, of 180±10 nM, being at least 200-fold selective for hrPDE7A1 over all other PDEs.

YN320972 VU 0357121 433967-28-3

VU 0357121 is a positive and highly selectivemGlu5Rallosteric modulator (PAM) with an EC50 of 33nM. VU 0357121 is inactive or very weakly antagonizing at other mGlu receptor subtypes.

YN481093 4-Hydroxyatomoxetine 435293-66-6

4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (K...

YN330176 GW274150 phosphate 438542-15-5

GW274150 phosphate is a potent, selective, orally active and NADPH-dependent inhibitor of humaninducible nitric oxide synthase (iNOS)(IC50=2.19μM;Kd=40nM) and ratiNOS(ED50=1.15μM). GW274150 phosphate displays le...

YN372247 Bay 60-7550 439083-90-6

Bay 60-7550 is a potent and selectivePDE2inhibitor with a Ki of 3.8nM.

YN290236 LDN-91946 439946-22-2

LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with aKi appof 2.8μM.

YN480110 WAY-200070 440122-66-7

WAY-200070 is a selective estrogen receptor β (ERRβ) agonist with an IC50 of 2.3nM.

YN1730027 Vipadenant 442908-10-3

Vipadenant (BIIB-014; CEB-4520) is anadenosine receptorantagonist, with Kis of 1.3nM and 68nM for A2A and A1, respectively.

YN1730016 A2A receptor antagonist 1 443103-97-7

A2AR antagonist 1 is a potent A2AR (Adenosine A2A Receptor) antagonist with Ki values of 4 nM and 264 nM for A2AR and A1R, respectively.

YN360680 SSR180711 hydrochloride 446031-79-4

SSR180711 hydrochloride is an orally active, selective and reversibleα7 acetylcholine nicotinic receptor (n-AChRs)partial agonist. SSR180711 hydrochloride can act on rat α7 n-AChR (Ki=22nM;IC50=30nM) and human α7 n-A...

YN320546 Pexacerfont 459856-18-9

Pexacerfont is a selective corticotropin-releasing factor (CRF1) receptor antagonist with IC50 of 6.1±0.6nM for human CRF1receptor.

YN360288 GT 949 460330-27-2

GT 949 is a selective excitatory amino acid transporter-2 (EAAT2) positive allosteric modulator with an EC50 of 0.26nM.

YN320559 ABT-239 460746-46-7

ABT-239 is a novel, highly efficacious, non-imidazole class ofH3Rantagonist and a transient receptor potential vanilloid type 1 (TRPV1) antagonist.

YN360133 Eact 461000-66-8

Eact is a selective and potent activator ofTMEM16A, directly activates the TRPV1 channels in sensory nociceptors and produces itch, acute nociception and thermal hypersensitivity.