YN320412 Risperidone hydrochloride 666179-74-4

Risperidone hydrochloride (R 64 766 hydrochloride)5-HT2receptorblocker,P-Glycoproteininhibitor and potentdopamine D2receptorantagonist, with Kisof 4.8, 5.9nM for 5-HT2A and dopamine D2receptor, respectively.

YN320413 Risperidone mesylate 666179-96-0

Risperidone mesylate(R 64 766 mesylate) is a serotonin5-HT2receptorblocker,P-Glycoproteininhibitor and potentdopamine D2receptorantagonist, with Kisof 4.8, 5.9nM for 5-HT2A and dopamine D2receptor, respectively.

YN320828 GW842166X 666260-75-9

GW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor. Phase 2.

YN420211 BIO-acetoxime 667463-85-6

BIO-acetoxime is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.

YN270373 LDN-57444 668467-91-2

LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3.

YN361043 α-Conotoxin PIA 669050-68-4

α-Conotoxin PIA is a nicotinic acetylcholine receptor (nAChR) antagonist isolated fromConus purpurascensthat targets nAChR subtypes containing α6 and α3 subunits. α-Conotoxin PIA has the potential for the research of P...

YN290178 IU1-47 670270-31-2

IU1-47 is a potent and specificUSP14inhibitor with an IC50 of 0.6μM. IU1-47 inhibits IsoT/USP5 with an IC50 of 20μM. IU1-47 induces tau elimination in cultured neurons.

YN480127 Dihydromunduletone 674786-20-0

Dihydromunduletone (DHM) is a rotenoid derivative and a selective, potentadhesion G protein-coupled receptor (aGPCR)(GPR56 and GPR114/ADGRG5) antagonist with an IC50 of 20.9μM forGPR56, but not inhibit GPR1...

YN380066 Dasotraline hydrochloride 675126-08-6

Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocksdopamine,norepinephrine, and serotonintransporters with IC50 values of 4, 6, and 11nM, respectively.

YN320351 Facinicline hydrochloride 677305-02-1

Facinicline hydrochloride (RG3487 hydrochloride) is an orally activenicotinic α7 receptorpartial agonist, with a Ki of 6nM for α7 human nAChR. Facinicline hydrochloride (RG3487 hydrochloride) improves cognition and sensorimot...

YN380100 K 01-162 677746-25-7

K 01-162 (K162) binds and destabilizes AβO (β-amyloid), with an EC50 of 80nM.

YN380087 MRK-560 677772-84-8

MRK-560 is a potent, orally bioavailable and brain-penetrantγ-secretaseinhibitor.

YN320379 EMPA 680590-49-2

EMPA is a high-affinity, reversible and selectiveorexin OX2receptorantagonist. [3H]EMPA binds to human and rat OX2-HEK293 membranes with KDvalues of 1.1 and 1.4nM respectively.

YN373392 JNJ-1661010 681136-29-8

JNJ-1661010 is a potent and selective FAAH inhibitor with IC50 of 10 nM (rat) and 12 nM (human), exhibits >100-fold selectivity for FAAH-1 when compared to FAAH-2.

YN480817 SynuClean-D 685121-45-3

SynuClean-D (SC-D) is an inhibitor ofα-synucleinaggregation, disrupts mature amyloid fibrils, prevents fibril propagation, and abolishes the degeneration of dopaminergic neurons in an animal model of Parkinson’s disease.

YN320868 NB001 686301-48-4

NB001 (HTS 09836) is anadenylcyclase 1 (AC1)inhibitor which has effect on neural and non-neural pain by modulating AC1 activity.

YN320899 CPPHA 693288-97-0

CPPHA is potent and selective positive allosteric modulator (PAM) of themGluR5 and mGluR1(metabotropic glutamate receptor). CPPHA can potentiate responses of mGluR5 and mGluR1 to activation of these receptors. CPP...

YN481638 BoNT-IN-1 694443-03-3

BoNT-IN-1 is a potent inhibitor of Botulinum neurotoxin A light chain (BoNTA LC) with IC50 of 0.9 uM.

YN380286 LPYFD-NH2 700361-48-4

LPYFD-NH2, a pentapeptide, exerts some inhibitory effect on the aggregation ofAβ(1-42). LPYFD-NH2 can be used for the research of Alzheimer’s disease.

YN360395 NMDA-IN-1 700878-19-9

NMDA-IN-1 is a potent and NR2B-selectivenMDA antagonist with Ki of 0.85nM; NR2B Ca2+ influx IC50 is 9.7nM; no activities on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor.