YN380088 Begacestat 769169-27-9

Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor proteingamma-secretase(IC50Aβ40=15nM) for the treatment of Alzheimer's disease.

YN321270 Telcagepant 781649-09-0

Telcagepant (MK-0974) is an orally activecalcitonin gene-related peptide (CGRP) receptorantagonist with Kis of 0.77nM and 1.2nM for human and rhesus CGRP receptors, respectively.

YN320894 CDPPB 781652-57-1

CDPPB is a potent, selective and brain penetrant positive allosteric modulator of themetabotropic glutamate receptor subtype 5 (mGluR5), with an EC50 of 27nM in Chinese hamster ovary cells expressing human mGluR5. CDPPB ...

YN320276 JDTic dihydrochloride 785835-79-2

JDTic (dihydrochloride) is a potent antagonist ofkappa-opioid receptors (KOR), blocking the κ-agonist U50, 488-induced antinociception.

YN320878 Olanzapine D3 786686-79-1

Olanzapine D3 (LY170053 D3) is the deuterium labeled Olanzapine. Olanzapine is a selective monoaminergic antagonist with high affinity binding toserotonin H1, 5HT2A/2C, 5HT3, 5HT6(Ki=7, 4, 11, 57, and 5nM, respectively),...

YN320499 (Rac)-E1R 787623-60-3

(Rac)-E1R (Compound 2) is the racemate of E1R. (Rac)-E1R is asigma-1 receptorpositive allosteric modulator (Sig1R PAM) used for the research of cognition/memory disorders.

YN380057 PBD-150 790663-33-1

PBD-150 is a humanglutaminyl cyclase (hQC) Y115E-Y117Evariant inhibitor, with aKivalue of 490nM.

YN370287 BI-6C9 791835-21-7

BI-6C9 is a highly specific BH3 interacting domain (Bid) inhibitor, which prevents mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protects the cells from mitochondrial apoptosis inducing factor (A...

YN320390 SB-334867 free base 792173-99-0

SB-334867 is a selective orexin-1 (OX1) receptor antagonist.

YN370295 BAY 73-6691 racemate 794568-90-4

BAY 73-6691 racemate is aphosphodiesterase 9inhibitor extracted from patent WO 2017070293 A1.

YN370294 BAY 73-6691 794568-92-6

BAY 73-6691 ((R)-BAY 73-6691) is a potent, brain penetrant, and selectivePDE9Ainhibitor.

YN360502 Sofiniclin 799279-80-4

Sofiniclin (ABT 894), an agonist ofnicotinic acetylcholine receptor (nAChR), is used as a potential non-stimulant research for attention-deficit/hyperactivity disorder (ADHD).

YN320990 Basimglurant 802906-73-6

Basimglurant (RG7090) is a potent, selective and orally availablemGlu5negative allosteric modulator with aKdof 1.1nM.

YN360170 Rislenemdaz 808732-98-1

Rislenemdaz (CERC-301) is an orally bioavailable and selectiveN-methyl-D-aspartate (NMDA) receptor subunit 2B(GluN2B) antagonist withKi and IC50 of 8.1nM and 3.6nM, respectively.

YN360316 Resolvin D2 810668-37-2

Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhib...

YN320909 Retosiban 820957-38-8

Retosiban (GSK221149A) is a potent and selective oxytocin antagonist with a Ki of 0.65nM.

YN360143 ML335 825658-06-8

ML335 is a selective activator of bothTREK-1 and TREK-2.

YN480773 ISX-9 832115-62-5

Isoxazole 9 (Isx-9) is a synthetic promotor of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells (NSPCs).

YN360261 Synta66 835904-51-3

Synta66 is an inhibitor of store-operated calcium entry channelOrai, which forms the pore of theCRACchannel, and used for the research of neurological disease.

YN320906 Cariprazine 839712-12-8

Cariprazine is a novel antipsychotic drug c and idate that exhibits high affinity for theD3(Ki=0.085nM) and D2(Ki=0.49nM) receptors, and moderate affinity for the5-HT1Areceptor (Ki=2.6nM).