YN320287 Nelotanserin 839713-36-9

Nelotanserin is a potent5-HT2Ainverse agonist, a moderately potent5-HT2Cpartial inverse agonist and a weak5-HT2Binverse agonist, with IC50s of 1.7, 79, 791nM in IP accumulation assays, respectively.

YN483851 Neuromedin S(rat) 843782-19-4

Neuromedin S(rat) is a 34-amino acids peptide from rat Neuromedin S. Neuromedin S. Neuromedin S is a neuropeptide isolated from rat brain, acts as lig and for the G protein-coupled receptor FM4/TGR-1

YN320857 GSK163090 844903-58-8

GSK163090 is a potent, selective and orally active5-HT1A/1B/1Dreceptorantagonist with pKi values. of 9.4/8.5/9.7, respectively. GSK163090 inhibits the functional activity of serotonin reuptake transporter (SerT) with apKiva...

YN360199 Bitopertin 845614-11-1

Bitopertin (RG1678,RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells.

YN360200 Bitopertin (R enantiomer) 845614-12-2

Bitopertin R enantiomer (RG1678 R enantiomer; RO4917838 R enantiomer) is the R-enantiomer of Bitopertin. Bitopertin is a potent, noncompetitiveglycine reuptakeinhibitor, inhibits glycine uptake at humanGlyT1with a concentration...

YN380027 BF 227 845647-80-5

BF 227 is a c and idate for an amyloid imaging probe for PET, with a Ki of 4.3nM forAβ1-42 fibrils.

YN321217 2-Methyl-5-HT hydrochloride 845861-49-6

2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) is a potent and selective5-HT3receptoragonist. 2-Methyl-5-HT hydrochloride is shown to display anti-depressive-like effects.

YN373289 N-(3-Methoxybenzyl)Palmitam... 847361-96-0

N-(3-Methoxybenzyl)Palmitamide is a promising inhibitor ofFAAHfor the treatment of pain, inflammation and CNS degenerative disorders.

YN320374 SHA 68 847553-89-3

SHA 68 is a potent and selective non-peptideneuropeptide S receptor (NPSR)antagonist with IC50s of 22.0 and 23.8nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 has limited the blood-brain barrier (BBB...

YN330673 Tat-NR2Baa 847829-41-8

Tat-NR2BAA is thecontrol peptideof Tat-NR2B9c (HY-P0117), inactive. The sequence of Tat-NR2BAA is similar to Tat-NR2B9c, but it has a double-point mutation in the COOH terminal tSXV motif, making it incapable ...

YN380042 RO4929097 847925-91-1

RO4929097 (RG-4733) is aγ secretaseinhibitor with IC50 of 4nM, inhibiting cellular processing of Aβ40 and Notch with EC50of 14nM and 5nM, respectively.

YN371237 Compound 48/80 trihydrochlori... 848035-21-2

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also ahistaminereleaser and amast celldegranulat...

YN320472 H4 Receptor antagonist 1 848217-00-5

H4 Receptor antagonist 1 is a potent and selectivehistamine H4 receptorinverse agonist, with an IC50 of 19nM.

YN320683 ADL-5859 850173-95-4

ADL5859 HCl is a δ-opioid receptor agonist with Ki of 0.8 nM, selectivity against opioid receptor κ, μ, and weak inhibitory activity at the hERG channel. Phase 2.

YN360748 Riluzole hydrochloride 850608-87-6

Riluzole hydrochloride is an anticonvulsant drug and belongs to the family of use-dependentNa+channelblocker which can also inhibitGABAuptake with an IC50 of 43μM.

YN321255 JNJ-18038683 851376-05-1

JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist, withpKisof 8.19, 8.20 for rat and human 5-HT7in HEK293 cells, respectively.

YN380144 ELN318463 851600-86-7

ELN318463 is an amyloid precursor protein (APP) selectiveγ-secretaseinhibitor. ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12nM and 656nM for PS1 and P...

YN320685 (R)-ADX-47273 851881-59-9

(R)-ADX-47273 is a potentmGluR5positive allosteric modulator, with an EC50 of 168nM for potentiation .

YN320684 ADX-47273 851881-60-2

ADX47273 is a potent and specific mGlu5 positive allosteric modulator(PAM) with EC50 of 0.17 μM, showing no activity at other mGlu subtypes.

YN320266 LY 541850 852679-76-6

LY 541850 is claimed from human ionotropic and metabotropic glutamate (mGlu) receptors expressed in non-neuronal cells. LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161μM and ...