YN280051 EACC 864941-31-1

EACC is a reversibleautophagyinhibitor, which can block autophagic flux. EACC selectively inhibits the translocation of autophagosome-specific SNARE Stx17 thereby blocking autophagosome-lysosome fusion.

YN420195 Tideglusib 865854-05-3

Tideglusib is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM in a cell-free assay fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. Phase 2.

YN1730064 L-745870 trihydrochloride 866021-03-6

L-745870 trihydrochloride is a potent, selective, brain-penetrant and orally activedopamine D4receptorantagonist with aKiof 0.43nM. L-745870 trihydrochloride shows weaker affinity for D2(Kiof 960nM) and D3(Kiof 2300nM) recept...

YN320987 Biphenylindanone A 866823-73-6

Biphenylindanone A (BINA) is a selective humanmGluR2(hmGluR2) potentiator for the treatment of many neurological disorders.

YN380043 Aftin-4 866893-90-5

Aftin-4 is anAmyloid-β42(Aβ42) inducer.

YN360033 IC87201 866927-10-8

IC87201, an inhibitor of PSD95-nNOS protein-protein interactions, suppresses NMDAR-dependent NO and cGMP formation.

YN370192 TRC051384 867164-40-7

TRC051384 is a heat shock protein 70 (HSP70) inducer.

YN320715 Org 27569 868273-06-7

Org 27569 is a potentCB1 receptorallosteric modulator, which increases agonist binding, yet blocks agonist-induced CB1 signaling.

YN360186 WAY-213613 868359-05-1

WAY-213613 is a potent, selective nonsubstrate reuptake inhibitor ofGLT-1/EAAT2with IC50 of 85nM EAAT2. It displays 59- and 44-fold selectivity over EAAT1 and EAAT3 (IC50s are 5 and 3.8μM, respectively). ...

YN320096 (R)-(-)-α-Methylhistamine d... 868698-49-1

(R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective H3 histaminereceptor agonist with aKdof 50.3nM. (R)-(-)-α-Methylhistamine dihydrobromide can cross the blood-brain barrier, and can enhance memory retention, at...

YN330668 TLQP-21 869988-94-3

TLQP-21, a VGF-derived peptide endowed of endocrine and extraendocrine properties, is a potentG-protein-coupled receptor complement-3a receptor 1 (C3aR1)agonist (EC50: mouse TLQP-21=10.3μM; human TLQP-21=68.8μM). T...

YN360469 A 839977 870061-27-1

A 839977 is aP2X7selective antagonist; it blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors (IC50 values are 20nM, 42nM and 150nM respectively) and reduces inflammatory and neuropath...

YN1730034 Tozadenant 870070-55-6

Tozadenant is anadenosine A2Areceptor antagonist, with Kiof 11.5nM on human A2A and 6nM on rhesus A2A.

YN320807 BPTU 870544-59-5

BPTU (BMS-646786) is a non-nucleotideP2Y1receptor allosteric antagonist with antithrombotic activity. BPTU is able to block the P2Y1 receptor located at the neuromuscular junction of the gastrointestinal tract.

YN380003 E 2012 870843-42-8

E 2012 is a potentgamma (γ) secretasemodulator without affecting Notch processing. E 2012 inhibits 3β-hydroxysterol Δ24-reductase(DHCR24)at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by re...

YN320350 Almorexant 871224-64-5

Almorexant (ACT 078573) is a potent and competitive dualorexin 1 receptor(OX1)/orexin 2 receptor(OX2) antagonist with Ki values of 1.3 and 0.17nM, respectively.

YN320989 CTEP 871362-31-1

CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over other mGlu receptors.

YN450110 H-1152 dihydrochloride 871543-07-6

H-1152 dihydrochloride (2HCl) is a membrane-permeable and selective inhibitor of Rho-associated protein kinase (ROCK). H-1152 inhibits ROCK2, PKA, PKC, PKG, AuroraA and CaMK2 with IC50 of 0.0120 μM, 3.03 μM,...

YN320920 Dipraglurant 872363-17-2

Dipraglurant (ADX48621) is a potent, selective, orally active and brain penetrantm GluR5 negative allosteric modulator (NAM), with an IC50 of 21nM. Dipraglurant can reduce Levodopa-induced dyskinesia (LID) in vivo.

YN280038 S29434 874484-20-5

S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor ofquinone reductase 2 (QR2), with IC50s ranging from 5 to 16nM for human QR2 at different organizational levels, and has good selectivity for...