Chemical structure
Cat.No.
Product Name
CAS no.
Target
YN321231 Isamoltane hemifumarate 874882-92-5
Isamoltane hemifumarate is a selective antagonist of5-HT1Breceptor, with an IC50 of 39nM for inhibits the binding of [125I]ICYP to 5-HT1Brecognition sites in rat brain membranes. Isamoltane hemifumarate is also aβ-adrenocep...
YN370429 LY2183240 874902-19-9
LY-2183240 is a potent, covalent inhibitor of the EC-degrading enzyme fatty acid amide hydrolase (FAAH). LY-2183240 disrupts the cellular uptake of the lipid endocannabinoid (EC) anandamide and promote analgesia in vivo. ...
YN360080 PF-01247324 875051-72-2
PF-01247324 is a selective and orally bioavailableNav1.8channel blocker with an IC50 of 196nM for recombinant human Nav1.8 channel.
YN360240 NS8593 hydrochloride 875755-24-1
NS8593 hydrochloride is a potent and selectivesmall conductance Ca2+-activated K+channels (SK channels)inhibitor. NS8593 hydrochloride reversibly inhibitsSK3-mediated currents with aKdvalue of 77nM. NS8593 hydrochloride inhi...
RF9 is a potent and selectiveNeuropeptide FF receptorantagonist, with Ki values of 58 and 75nM forhNPFF1R and hNPFF2R, respectively.
ML221 is a potent apelin receptor (APJ) functional antagonist in cell-based assays that is >37-fold selective over the closely related angiotensin II type 1 (AT1) receptor. The IC50 values of ML221 are 0.70 and 1.75 μM in a ...
LOC14 is a potent inhibitor of protein disulfide isomerase (PDI) with EC50 of 500 nM and Kd of 62 nM, respectively.
COG1410 is an apolipoprotein E-derived peptide. COG1410 exerts neuroprotective and antiinflammatory effects in a murine model of traumatic brain injury (TBI). COG1410 can be used for the research of neurological disease.
PA-8 is a potent, selective and orally activePACAP type I (PAC1) receptorantagonist. PA-8 inhibits the phosphorylation of CREB induced by PACAP inPAC1-, but not VPAC1- or VPAC2-receptor. PA-8 also inhibi...
WRW4, a specificformyl peptide receptor-like 1 (FPRL1)antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MM...
AKOS-22 is a potent mitochondrial proteinVDAC1(voltage-dependent anion channel 1) inhibitor (Kd=15.4μM). AKOS-22 interacts with VDAC1 and inhibiting both VDAC1 oligomerization and apoptosis. AKOS-22 protects a...
YN480283 Neuropathiazol 880090-88-0
Neuropathiazol is a small molecule, selectively induces neuronal differentiation of multipotent hippocampal neural progenitor cells.
Anle138b is a novel oligomer modulator and an aggregation inhibitor, blocking the formation of pathological aggregates of prion protein (PrP(Sc)) and of α-synuclein (α-syn) with good oral bioavailability, blood-brain-bar...
YN320067 Keto Ziprasidone 884305-07-1
Keto Ziprasidone is an impurity of Ziprasidone. Ziprasidone, an antipsychotic agent, is a combined 5-HT (serotonin) and dopamine receptor antagonist.
YN320068 Hydroxy ziprasidone 884305-08-2
Hydroxy ziprasidone is an impurity of Ziprasidone. Ziprasidone, an antipsychotic agent, is a combined 5-HT (serotonin) and dopamine receptor antagonist.
YN320924 Verucerfont 885220-61-1
Verucerfont is acorticotropin-releasing factor receptor 1(CRF1) antagonist with IC50s of ~6.1, >1000 and >1000 nM for CRF1, CRF2, and CRF-BP, respectively.
YN321045 LY2119620 886047-22-9
LY2119620 is a high-affinity muscarinicM2/M4receptoragonist.
YN320431 Vabicaserin hydrochloride 887258-94-8
Vabicaserin hydrochloride is a 5-hydroxytryptamine 2C (5-HT2C)receptor-selective agonist with an EC50 of 8nM.
YN450105 Ripasudil 887375-67-9
Ripasudil (K-115) hydrochloride dihydrate is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension.
ZSET1446 is a novel cognitive enhancer that significantly improves learning deficits in various types of Alzheimer disease (AD) models.
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