YN321232 Naldemedine 916072-89-4

Naldemedine (S-297995) is an orally active, peripherally actingµ-opioid receptorantagonist. Naldemedine shows potent binding affinities (IC50s = 1.15, 1.11, and 1.5nM, repectively) and antagonist activities (IC50s= 25.57, 7.09,...

YN360435 N-Methyl Duloxetine hydroch... 916135-70-1

N-Methyl Duloxetine hydrochloride is an analgesic. N-Methyl Duloxetine (hydrochloride) elicits both tonic and use-dependent block of neuronal Na+channels.

YN320392 TCS 1102 916141-36-1

TCS 1102 is a potent, dual orexin receptor antagonist (Ki values are 0.2 and 3nM for OX2 and OX1 receptors respectively).

YN360169 Salfaprodil 916214-57-8

Salfaprodil (Neu2000 potassium) is an NR2B-selective and uncompetitive antagonist ofN-methyl-D-aspartate (NMDA), and a free radical scavenger. Salfaprodil has excellent neuroprotection againstnMDA- and free radical-indu...

YN322023 Ansofaxine hydrochloride 916918-84-8

Ansofaxine hydrochloride (LY03005; LPM570065) is a triple reuptake inhibitor; inhibitsserotonin,dopamine and norepinephrinereuptake with IC50 values of 723, 491 and 763nM, respectively.

YN360677 Lorediplon 917393-39-6

Lorediplon is a novel non-benzodiazepine, hypnotic drug acting as a GABAA receptor modulator, differentially active at the alpha1-subunit, associated with promoting sleep. Lorediplon is a drug for the treatment of insomnia, has been ...

YN360312 CCMI 917837-54-8

CCMI is a potent and selectiveα7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. ...

YN320672 RG7713 920022-47-5

RG7713 (RO5028442) is a highly potent and selectiveBrain-Penetrant Vasopressin 1a(V1a) receptor antagonist with Kis of 1nM (hV1a) and 39nM (mV1a).

YN372241 Opicapone 923287-50-7

Opicapone is a potent third-generation catechol-O-methyltransferase (COMT) inhibitor for the research of Parkinson's disease and motor fluctuations. Opicapone decreases the ATP content of the cells with an IC50 of 98μM.

YN321088 Centanafadine hydrochloride 923981-14-0

Centanafadine (hydrochloride) is dualnorepinephrine (NE)/dopamine (DA)transporter inhibitor, also inhibits serotonin transporter, with IC50s of 6nM, 38nM and 83nM for human NE, DA and serotonin transporter , respectively.

YN440212 BT-13 924537-98-4

BT-13 is a potent and selectiveglial cell line-derived neurotrophic factor (GDNF) receptor RETagonist independently of GFLs, promoting neurite growth from sensory neurons in vitro and attenuates experimental neuropathy in th...

YN480496 BT18 924811-53-0

BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF). BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function.

YN483880 Ac-Leu-Arg-AMC 929621-79-4

Ac-Leu-Arg-AMC is a fluorogenic peptide substrate.

YN360378 Raxatrigine 934240-30-9

Raxatrigine (GSK-1014802) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor.

YN360379 Raxatrigine hydrochloride 934240-31-0

Raxatrigine hydrochloride (GSK-1014802 hydrochloride) is a novel small molecule state-dependent sodium channel blocker; Nav1.7 sodium channel inhibitor.

YN320415 AZD 2066 934282-55-0

AZD 2066 is a selective, orally active and brain-penetrant antagonist ofmGluR5. AZD 2066 has antinociception effects.

YN480445 TH-237A 935467-97-3

TH-237A(meso-GS 164) is a novel neuroprotective agent exhibiting favorable permeation across the blood brain barrier. IC50 value: 5nM (EC50, concentration that leads to a 50% increase in neuronal survival in the presence of the A...

YN320587 PF-03654764 935840-35-0

PF-03654764 is an orally active, selective histamineH3receptor antagonist with Ki values of 1.2nM and 7.9nM for human H3 and rat H3in whole cell assay, respectively. The combination of PF-03654764 and Fexofenadine (HY-B0...

YN370153 Cyclo(his-pro) TFA 936749-56-3

Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone. Cyclo(his-pro) TFA could inhibitNF-κBnuclear accumulation. Cyclo(his-pro) TFA c...

YN450027 Neurodazine 937807-66-4

Neurodazine is an imidazole-based small molecule, serve as a promoter ofneurogenesisin pluripotent cells. Neurodazine promotes neurogenesis by activatingWnt and Shhsignaling pathways. Neurodazine selectively suppresses astrocyte differ...