YN320288 Temanogrel 887936-68-7

Temanogrel is a highly selective5-HT2Areceptorantagonist with a Ki of 4.9nM.

YN330530 Epiberberine chloride 889665-86-5

Epiberberine chloride is an alkaloid isolated fromCoptis chinensis, acts as a potentAChE and BChEinhibitor, and a non-competitiveBACE1inhibitor, with IC50s of 1.07, 6.03 and 8.55μM, respectively. Epiberberine chloride h...

YN322084 CB1 antagonist 1 890037-68-0

CB1 antagonist 1 is an antagonist ofCB1 receptor, used in the research of metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, gastrointestinal disorders, and cardiovascular conditions.

YN372467 Verdiperstat 890655-80-8

Verdiperstat (AZD3241) is a selective, orally active and irreversible inhibitor of myeloperoxidase (MPO) with IC50 of 630 nM. Verdiperstat (AZD3241) can be used in the research of neurodegenerative brain disorders.

YN320324 VU-29 890764-36-0

VU-29 is a positive allosteric modulator ofmetabotropic glutamate 5 (mGlu5) receptor(EC50=9nM and Ki=244nM for rmGluR5). VU-29 is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557nM/1.5...

YN320766 TAN-452 892039-23-5

TAN-452 is an orally active, selective peripherally actingδ-opioid receptor (DOR)antagonist with a Ki of 0.47 nM and aKbof 0.21 nM. TAN-452 is an antagonist forμ-opioid receptor(MOR;Ki=36.56 nM and Kb=9.43 nM) ...

YN480269 PH-064 892546-37-1

PH-064 (BIM-46187) is an inhibitor of heterotrimeric G-protein complex.

YN360371 LDN-212320 894002-50-7

LDN-212320 (LDN-0212320) is aglutamate transporter (GLT-1)/excitatory amino acid transporter 2 (EAAT2)activator (at translational level). LDN-212320 (LDN-0212320) prevents nociceptive pain by upregulating astroglial GLT...

YN372632 Mardepodect 898562-94-2

Mardepodect (PF-2545920) is a potent, orally active and selectivePDE10Ainhibitor with an IC50 of 0.37nM, with >1000-fold selectivity over otherPDEs. Mardepodect can cross the blood-brain barrier.

YN360544 A 438079 hydrochloride 899431-18-6

A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9.

YN360543 A 438079 899507-36-9

A 438079 is a potent, and selectiveP2X7receptorantagonist with pIC50 of 6.9.

YN320562 Pitolisant hydrochloride 903576-44-3

Pitolisant acts as a high-affinity competitive antagonist (Ki=0.16 nM) and as an inverse agonist (EC50=1.5 nM) at the human histamine H3 receptor subtype.

YN480594 Inflachromene 908568-01-4

Inflachromene, a microglial inhibitor, binds toHMGB1 and HMGB2 and exerts anti-inflammatory effects. Inflachromene effectively downregulates proinflammatory functions ofHMGB and reduces neuronal damage. Inflachromene can be...

YN321225 SB-616234-A 908601-49-0

SB-616234-A is a selective and orally bioavailable5-HT1B receptorantagonist, with anxiolytic and antidepressant activity.

YN484254 Potassium Channel Activator... 908608-06-0

Potassium Channel Activator 1 is an agent for treating, one or more disorders or conditions wherein the dopaminergic system is disrupted, such as one or more disorders or conditions independently selected from the group consisting of: sc...

YN360142 TTA-Q6 910484-28-5

TTA-Q6 is a selectiveT-type Ca2+channelantagonist, which can be used in the research of neurological disease.

YN321091 Decoglurant 911115-16-7

Decoglurant (RO4995819) is a negative allosteric modulator ofmGluR2 and mGluR3. Decoglurant is developed as an antidepressant.

YN360643 Cenobamate 913088-80-9

Cenobamate, asodium channelblocker, enhancesGABAergictransmission and has the potential to be a versatile CNS drug.

YN320352 Almorexant hydrochloride 913358-93-7

Almorexant HCl is an orally active, dual orexin receptor antagonist with IC50 of 6.6 nM and 3.4 nM for OX1 and OX2 receptor, respectively. Phase 3.

YN321034 Brexpiprazole 913611-97-9

Brexpiprazole is a novel D2 dopamine and serotonin 1A partial agonist, called serotonin-dopamine activity modulator (SDAM), and a potent antagonist of serotonin 2A receptors, noradrenergic alpha 1B and 2C receptors with Ki values...